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The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis
Abstract
The X-Notch-1 receptor, and its putative ligand, X-Delta-1, are thought to mediate an inhibitory cell-cell interaction, called lateral inhibition, that limits the number of primary neurons that form in Xenopus embryos. The expression of Xenopus ESR-1, a gene related to Drosophila Enhancer of split, appears to be induced by Notch signaling during this process. To determine how the activation of X-Notch-1 induces ESR-1 expression and regulates primary neurogenesis, we isolated the Xenopus homolog of Suppressor of Hairless (X-Su(H)), a component of the Notch signaling pathway in Drosophila. Using animal cap assays, we show that X-Su(H) induces ESR-1 expression, perhaps directly, when modified by the addition of ankyrin repeats. Using a DNA binding mutant of X-Su(H), we show that X-Su(H) activity is required for induction of ESR-1. Finally, expression of the DNA binding mutant in embryos leads to a neurogenic phenotype as well as increased expression of both X-Delta-1 and XNGNR1, a proneural gene expressed during primary neurogenesis. These results suggest that activation of X-Su(H) is a key step in the Notch signaling pathway during primary neurogenesis in Xenopus embryos.
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Cited by
Lawson, N. D., Scheer, N., Pham, V. N., Kim, C.-H., Chitnis, A. B., Campos-Ortega, J. A., & Weinstein, B. M. (2001) · Development · doi:10.1242/dev.128.19.3675 · Cited by 915
Morrison, S. J., Perez, S. E., Qiao, Z., Verdi, J. M., Hicks, C., Weinmaster, G., & Anderson, D. J. (2000) · Cell · doi:10.1016/s0092-8674(00)80860-0 · Cited by 721
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Ishitani, T., Hirao, T., Suzuki, M., Isoda, M., Ishitani, S., Harigaya, K., Kitagawa, M., Matsumoto, K., & Itoh, M. (2010) · Nature Cell Biology · doi:10.1038/ncb2028 · Cited by 131
The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons
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Metadata
- Authors
- Wettstein, D. A., Turner, D. L., & Kintner, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1997-02-01
- Volume
- 124
- Issue
- 3
- Pages
- 693-702
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2095969687
- Cited by
- 287
- References
- 0
- FWCI
- 6.86
- Type
- journal article
- Language
- en
- Open access
- closed
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