The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
PAR-6 is a conserved PDZ domain-containing protein that colocalizes with PAR-3 in Caenorhabditis elegans embryos
Abstract
The par genes are required to establish polarity in the Caenorhabditis elegans embryo. Mutations in two of these genes, par-3 and par-6, exhibit similar phenotypes. A third gene, pkc-3, gives a similar phenotype when the protein is depleted by RNA interference. PAR-3 and PKC-3 protein are colocalized to the anterior periphery of asymmetrically dividing cells of the germline lineage and the peripheral localizations of both proteins depends upon the activity of par-6. Here we report the molecular cloning of par-6 and the immunolocalization of PAR-6 protein. We found that par-6 encodes a PDZ-domain-containing protein and has homologues in mammals and flies. Moreover, we discovered that PAR-6 colocalizes with PAR-3 and that par-3 and pkc-3 activity are required for the peripheral localization of PAR-6. The localization of both PAR-3 and PAR-6 proteins is affected identically by mutations in the par-2, par-4 and par-5 genes. The co-dependence of PAR-3, PAR-6 and PKC-3 for peripheral localization and the overlap in their distributions lead us to propose that they act in a protein complex.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
Cited by
Integrin-Mediated Activation of Cdc42 Controls Cell Polarity in Migrating Astrocytes through PKCζ
Etienne-Manneville, S., & Hall, A. (2001) · Cell · doi:10.1016/s0092-8674(01)00471-8 · Cited by 1,018
The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
Joberty, G., Petersen, C., Gao, L., & Macara, I. G. (2000) · Nature Cell Biology · doi:10.1038/35019573 · Cited by 928
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III
Gönczy, P., Echeverri, C., Oegema, K., Coulson, A., Jones, S. J. M., Copley, R. R., Duperon, J., Oegema, J., Brehm, M., Cassin, E., et al. (2000) · Nature · doi:10.1038/35042526 · Cited by 867
The PAR Proteins: Fundamental Players in Animal Cell Polarization
Goldstein, B., & Macara, I. G. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.10.007 · Cited by 758
A mammalian PAR-3–PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
Lin, D., Edwards, A. S., Fawcett, J. P., Mbamalu, G., Scott, J. D., & Pawson, T. (2000) · Nature Cell Biology · doi:10.1038/35019582 · Cited by 743
Asymmetric cell division: recent developments and their implications for tumour biology
Knoblich, J. A. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3010 · Cited by 578
Regulation of cell polarity and protrusion formation by targeting RhoA for degradation
Wang, H.-R., Zhang, Y., Ozdamar, B., Ogunjimi, A. A., Alexandrova, E., Thomsen, G. H., & Wrana, J. L. (2003) · Science · doi:10.1126/science.1090772 · Cited by 551
Mechanisms of asymmetric cell division: flies and worms pave the way
Gönczy, P. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2388 · Cited by 489
PKC and the control of localized signal dynamics
Rosse, C., Linch, M., Kermorgant, S., Cameron, A. J. M., Boeckeler, K., & Parker, P. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2847 · Cited by 477
Wodarz, A., Ramrath, A., Grimm, A., & Knust, E. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.150.6.1361 · Cited by 472
Assémat, E., Bazellières, E., Pallesi-Pocachard, E., Le Bivic, A., & Massey-Harroche, D. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.08.029 · Cited by 470
Bazooka provides an apical cue for Inscuteable localization in Drosophila neuroblasts
Wodarz, A., Ramrath, A., Kuchinke, U., & Knust, E. (1999) · Nature · doi:10.1038/990128 · Cited by 451
DmPAR-6 directs epithelial polarity and asymmetric cell division of neuroblasts in Drosophila
Petronczki, M., & Knoblich, J. A. (2001) · Nature Cell Biology · doi:10.1038/35050550 · Cited by 419
The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM)
Ebnet, K. (2001) · The EMBO Journal · doi:10.1093/emboj/20.14.3738 · Cited by 395
Macara, I. G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1332 · Cited by 341
Yamanaka, T., Horikoshi, Y., Suzuki, A., Sugiyama, Y., Kitamura, K., Maniwa, R., Nagai, Y., Yamashita, A., Hirose, T., Ishikawa, H., et al. (2001) · Genes to Cells · doi:10.1046/j.1365-2443.2001.00453.x · Cited by 306
Neuronal Polarity and Trafficking
Horton, A. C., & Ehlers, M. D. (2003) · Neuron · doi:10.1016/s0896-6273(03)00629-9 · Cited by 298
Harris, T. J. C., & Peifer, M. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505127 · Cited by 295
TGF-β Signaling Specifies Axons during Brain Development
Yi, J. J., Barnes, A. P., Hand, R., Polleux, F., & Ehlers, M. D. (2010) · Cell · doi:10.1016/j.cell.2010.06.010 · Cited by 284
aPKC Phosphorylation of Bazooka Defines the Apical/Lateral Border in Drosophila Epithelial Cells
Morais-de-Sá, E., Mirouse, V., & St Johnston, D. (2010) · Cell · doi:10.1016/j.cell.2010.02.040 · Cited by 282
Qiu, R.-G., Abo, A., & Martin, G. S. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00535-2 · Cited by 276
Suzuki, A., Ishiyama, C., Hashiba, K., Shimizu, M., Ebnet, K., & Ohno, S. (2002) · Journal of Cell Science · doi:10.1242/jcs.00032 · Cited by 251
Johansson, A.-S., Driessens, M., & Aspenström, P. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.18.3267 · Cited by 146
Hallam, S. J., Goncharov, A., McEwen, J., Baran, R., & Jin, Y. (2002) · Nature Neuroscience · doi:10.1038/nn959 · Cited by 118
Metadata
- Authors
- Hung, T.-J., & Kemphues, K. J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-01-01
- Volume
- 126
- Issue
- 1
- Pages
- 127-135
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1774057457
- Cited by
- 285
- References
- 2
- FWCI
- 6.63
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
