The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Regulation of midline development by antagonism of lefty and nodal signaling
Abstract
The embryonic midline is crucial for the development of embryonic pattern including bilateral symmetry and left-right asymmetry. In zebrafish, lefty1 (lft1) and lefty2 (lft2) have distinct midline expression domains along the anteroposterior axis that overlap with the expression patterns of the nodal-related genes cyclops and squint. Altered expression patterns of lft1 and lft2 in zebrafish mutants that affect midline development suggests different upstream pathways regulate each expression domain. Ectopic expression analysis demonstrates that a balance of lefty and cyclops signaling is required for normal mesendoderm patterning and goosecoid, no tail and pitx2 expression. In late somite-stage embryos, lft1 and lft2 are expressed asymmetrically in the left diencephalon and left lateral plate respectively, suggesting an additional role in laterality development. A model is proposed by which the vertebrate midline, and thus bilateral symmetry, is established and maintained by antagonistic interactions among co-expressed members of the lefty and nodal subfamilies of TGF-β signaling molecules.
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Cites
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A molecular pathway determining left-right asymmetry in chick embryogenesis
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Diversity and Pattern in the Developing Spinal Cord
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Origin and organization of the zebrafish fate map
Kimmel, C. B., Warga, R. M., & Schilling, T. F. (1990) · Development · doi:10.1242/dev.108.4.581 · Cited by 707
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Zebrafish organizer development and germ-layer formation require nodal-related signals
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no tail (ntl) is the zebrafish homologue of the mouse T (Brachyury) gene
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Cited by
Establishment of vertebrate left–right asymmetry
Hamada, H., Meno, C., Watanabe, D., & Saijoh, Y. (2002) · Nature Reviews Genetics · doi:10.1038/nrg732 · Cited by 489
Long, S., Ahmad, N., & Rebagliati, M. (2003) · Development · doi:10.1242/dev.00436 · Cited by 366
Danilova, N., Sakamoto, K. M., & Lin, S. (2008) · Blood · doi:10.1182/blood-2008-01-132290 · Cited by 291
Poulain, M., & Lepage, T. (2002) · Development · doi:10.1242/dev.129.21.4901 · Cited by 96
Metadata
- Authors
- Brent, W. B., Jeffrey, J. E., & Joseph, Y. H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 1999-07-15
- Volume
- 126
- Issue
- 14
- Pages
- 3253-3262
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1861727770
- Cited by
- 266
- References
- 51
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
