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Cited by 266

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Regulation of midline development by antagonism of lefty and nodal signaling

Brent, W. Bisgrove, Jeffrey, J. Essner, Joseph, Yost H.·1999·Development
DOI 10.1242/dev.126.14.3253
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Abstract

The embryonic midline is crucial for the development of embryonic pattern including bilateral symmetry and left-right asymmetry. In zebrafish, lefty1 (lft1) and lefty2 (lft2) have distinct midline expression domains along the anteroposterior axis that overlap with the expression patterns of the nodal-related genes cyclops and squint. Altered expression patterns of lft1 and lft2 in zebrafish mutants that affect midline development suggests different upstream pathways regulate each expression domain. Ectopic expression analysis demonstrates that a balance of lefty and cyclops signaling is required for normal mesendoderm patterning and goosecoid, no tail and pitx2 expression. In late somite-stage embryos, lft1 and lft2 are expressed asymmetrically in the left diencephalon and left lateral plate respectively, suggesting an additional role in laterality development. A model is proposed by which the vertebrate midline, and thus bilateral symmetry, is established and maintained by antagonistic interactions among co-expressed members of the lefty and nodal subfamilies of TGF-β signaling molecules.

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Metadata

Authors
Brent, W. B., Jeffrey, J. E., & Joseph, Y. H.
Venue
Development
Publisher
The Company of Biologists
Published
1999-07-15
Volume
126
Issue
14
Pages
3253-3262
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.126.14.3253
OpenAlex
W1861727770
Cited by
266
References
51
FWCI
8.16
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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