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Cited by 276

The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.

Ecdysone response genes govern egg chamber development during mid-oogenesis in Drosophila

Buszczak, Michael, Freeman, Marc R., Carlson, John R., Bender, Michael, Cooley, Lynn, Segraves, William A.·1999·Development
DOI 10.1242/dev.126.20.4581
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Abstract

The steroid hormone ecdysone regulates larval development and metamorphosis in Drosophila melanogaster through a complex genetic hierarchy that begins with a small set of early response genes. Here, we present data indicating that the ecdysone response hierarchy also mediates egg chamber maturation during mid-oogenesis. E75, E74 and BR-C are expressed in a stage-specific manner while EcR expression is ubiquitous throughout oogenesis. Decreasing or increasing the ovarian ecdysone titer using a temperature-sensitive mutation or exogenous ecdysone results in corresponding changes in early gene expression. The stage 10 follicle cell expression of E75 in wild-type, K10 and EGF receptor (Egfr) mutant egg chambers reveals regulation of E75 by both the Egfr and ecdysone signaling pathways. Genetic analysis indicates a germline requirement for ecdysone-responsive gene expression. Germline clones of E75 mutations arrest and degenerate during mid-oogenesis and EcR germline clones exhibit a similar phenotype, demonstrating a functional requirement for ecdysone responsiveness during the vitellogenic phase of oogenesis. Finally, the expression of Drosophila Adrenodoxin Reductase increases during mid-oogenesis and clonal analysis confirms that this steroidogenic enzyme is required in the germline for egg chamber development. Together these data suggest that the temporal expression profile of E75, E74 and BR-C may be a functional reflection of ecdysone levels and that ecdysone provides temporal signals regulating the progression of oogenesis and proper specification of dorsal follicle cell fates.

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Metadata

Authors
Buszczak, M., Freeman, M. R., Carlson, J. R., Bender, M., Cooley, L., & Segraves, W. A.
Venue
Development
Publisher
The Company of Biologists
Published
1999-10-15
Volume
126
Issue
20
Pages
4581-4589
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.126.20.4581
OpenAlex
W1832760132
Cited by
276
References
47
FWCI
3.59
Type
journal article
Language
en
Open access
closed

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