The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation
Abstract
An intracellular timer in oligodendrocyte precursor cells is thought to help control the timing of their differentiation. We show here that the expression of the Hes5 and Mash1 genes, which encode neural-specific bHLH proteins, decrease and increase, respectively, in these cells with a time course expected if the proteins are part of the timer. We show that enforced expression of Hes5 in purified precursor cells strongly inhibits the normal increase in the thyroid hormone receptor protein TRβ1, which is thought to be part of the timing mechanism; it also strongly inhibits the differentiation induced by either mitogen withdrawal or thyroid hormone treatment. Enforced expression of Mash1, by contrast, somewhat accelerates the increase in TRβ1 protein. These findings suggest that Hes5 and Mash1 may be part of the cell-intrinsic timer in the precursor cells.
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Cites
Cell death and control of cell survival in the oligodendrocyte lineage
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Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. II. Time of origin
Skoff, R. P., Price, D. L., & Stocks, A. (1976) · Journal of Comparative Neurology · doi:10.1002/cne.901690304 · Cited by 312
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Cited by
MicroRNA-Mediated Control of Oligodendrocyte Differentiation
Zhao, X., He, X., Han, X., Yu, Y., Ye, F., Chen, Y., Hoang, T., Xu, X., Mi, Q.-S., Xin, M., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.02.018 · Cited by 508
Corces, M. R., Shcherbina, A., Kundu, S., Gloudemans, M. J., Frésard, L., Granja, J. M., Louie, B. H., Eulalio, T., Shams, S., Bagdatli, S. T., et al. (2020) · Nature Genetics · doi:10.1038/s41588-020-00721-x · Cited by 358
Direct lineage conversions: unnatural but useful?
Vierbuchen, T., & Wernig, M. (2011) · Nature Biotechnology · doi:10.1038/nbt.1946 · Cited by 259
Notch1 control of oligodendrocyte differentiation in the spinal cord
Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S. S., Suter, U., Nave, K.-A., & Mantei, N. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202002 · Cited by 211
Ascl1/Mash1 Promotes Brain Oligodendrogenesis during Myelination and Remyelination
Nakatani, H., Martin, E., Hassani, H., Clavairoly, A., Maire, C. L., Viadieu, A., Kerninon, C., Delmasure, A., Frah, M., Weber, M., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0805-13.2013 · Cited by 158
Metadata
- Authors
- Kondo, T., & Raff, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-07-15
- Volume
- 127
- Issue
- 14
- Pages
- 2989-2998
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2297276306
- Cited by
- 159
- References
- 5
- FWCI
- 2.17
- Type
- journal article
- Language
- en
- Open access
- closed
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