The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
β-catenin mediates the specification of endoderm cells in ascidian embryos
Abstract
In the present study, we addressed the role of β-catenin in the specification of embryonic cells of the ascidians Ciona intestinalis and C. savignyi and obtained the following results: (1) During cleavages, β-catenin accumulated in the nuclei of vegetal blastomeres, suggesting that it plays a role in the specification of endoderm. (2) Mis- and/or overexpression of β-catenin induced the development of an endoderm-specific alkaline phosphatase (AP) in presumptive notochord cells and epidermis cells without affecting differentiation of primary lineage muscle cells. (3) Downregulation of β-catenin induced by the overexpression of cadherin resulted in the suppression of endoderm cell differentiation. This suppression was compensated for by the differentiation of extra epidermis cells. (4) Specification of notochord cells did not take place in the absence of endoderm differentiation. Both the overexpression of β-catenin in presumptive notochord cells and the downregulation of β-catenin in presumptive endoderm cells led to the suppression of Brachyury gene expression, resulting in the failure of notochord specification. These results suggest that the accumulation of β-catenin in the nuclei of endoderm progenitor cells is the first step in the process of ascidian endoderm specification.
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Cites
Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
Stambolic, V., Ruel, L., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70790-2 · Cited by 1,321
How embryos work: a comparative view of diverse modes of cell fate specification
Davidson, E. H. (1990) · Development · doi:10.1242/dev.108.3.365 · Cited by 267
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Lee, P. N., Kumburegama, S., Marlow, H. Q., Martindale, M. Q., & Wikramanayake, A. H. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.05.040 · Cited by 135
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Metadata
- Authors
- Imai, K., Takada, N., Satoh, N., & Satou, Y.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-07-15
- Volume
- 127
- Issue
- 14
- Pages
- 3009-3020
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2095869247
- Cited by
- 236
- References
- 2
- FWCI
- 4.73
- Type
- journal article
- Language
- en
- Open access
- closed
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