The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Ectopic Hoxa2 induction after neural crest migration results in homeosis of jaw elements in Xenopus
Abstract
Hox genes are required to pattern neural crest (NC) derived craniofacial and visceral skeletal structures. However, the temporal requirement of Hox patterning activity is not known. Here, we use an inducible system to establish Hoxa2 activity at distinct NC migratory stages in Xenopus embryos. We uncover stage-specific effects of Hoxa2 gain-of-function suggesting a multistep patterning process for hindbrain NC. Most interestingly, we show that Hoxa2 induction at postmigratory stages results in mirror image homeotic transformation of a subset of jaw elements, normally devoid of Hox expression, towards hyoid morphology. This is the reverse phenotype to that observed in the Hoxa2 knockout. These data demonstrate that the skeletal pattern of rhombomeric mandibular crest is not committed before migration and further implicate Hoxa2 as a true selector of hyoid fate. Moreover, the demonstration that the expression of Hoxa2 alone is sufficient to transform the upper jaw and its joint selectively may have implications for the evolution of jaws.
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Cites
Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4
Golding, J. P., Trainor, P., Krumlauf, R., & Gassmann, M. (2000) · Nature Cell Biology · doi:10.1038/35000058 · Cited by 181
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Minoux, M., & Rijli, F. M. (2010) · Development · doi:10.1242/dev.040048 · Cited by 507
Self-citationCranial neural crest and the building of the vertebrate head
Santagati, F., & Rijli, F. M. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1221 · Cited by 461
Self-citationCouly, G., Creuzet, S., Bennaceur, S., Vincent, C., & Le Douarin, N. M. (2002) · Development · doi:10.1242/dev.129.4.1061 · Cited by 420
An ancient gene network is co-opted for teeth on old and new jaws
Fraser, G. J., Hulsey, C. D., Bloomquist, R. F., Uyesugi, K., Manley, N. R., & Streelman, J. T. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000031 · Cited by 228
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Mouse Hoxa2 mutations provide a model for microtia and auricle duplication
Minoux, M., Kratochwil, C. F., Ducret, S., Amin, S., Kitazawa, T., Kurihara, H., Bobola, N., Vilain, N., & Rijli, F. M. (2013) · Development · doi:10.1242/dev.098046 · Cited by 97
Self-citationRostral and caudal pharyngeal arches share a common neural crest ground pattern
Minoux, M., Antonarakis, G. S., Kmita, M., Duboule, D., & Rijli, F. M. (2009) · Development · doi:10.1242/dev.028621 · Cited by 88
Self-citationTümpel, S., Cambronero, F., Ferretti, E., Blasi, F., Wiedemann, L. M., & Krumlauf, R. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2006.10.029 · Cited by 79
Knight, R. D., Javidan, Y., Nelson, S., Zhang, T., & Schilling, T. (2004) · Developmental Dynamics · doi:10.1002/dvdy.10494 · Cited by 65
Metadata
- Authors
- Pasqualetti, M., Ori, M., Nardi, I., & Rijli, F. M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-12-15
- Volume
- 127
- Issue
- 24
- Pages
- 5367-5378
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2282572666
- Cited by
- 209
- References
- 1
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- closed
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