The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state
Abstract
VEGF-A has been implicated in regulating the initial angiogenic invasion events that are essential for endochondral bone formation. VEGF-A mRNA expression was indeed found in the sclerotome of the developing somite and in the limb-bud mesenchyme at E10.5 in mouse development but declined during chondrogenesis and became upregulated in hypertrophic chondrocytes prior to angiogenic invasion. To determine the functional importance of VEGF-A expression in the developing chondrogenic tissues, VEGF-A was conditionally inactivated during early embryonic development using Collagen2a1-Cre transgenic lines. Deletion of a single VEGF-A allele in Collagen2a1-Cre-expressing cells results in embryonic lethality around E10.5. This lethality is characterized by aberrant development of the dorsal aorta and intersomitic blood vessels, along with defects in the developing endocardial and myocardial layers of the heart. A small percentage of VEGFFlox/+, Collagen2a1-Cre fetuses survive until E17.5, show aberrant endochondral bone formation and develop a heart phenotype resembling a dilated form of ischemic cardiomyopathy. These results provide insights into the function of VEGF-A in heart and endochondral bone formation and underscore the importance of tightly controlled levels of VEGF-A during development.
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Citations
Cites
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Cited by
The biology of VEGF and its receptors
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Self-citationYang, J. C., Haworth, L., Sherry, R. M., Hwu, P., Schwartzentruber, D. J., Topalian, S. L., Steinberg, S. M., Chen, H. X., & Rosenberg, S. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021491 · Cited by 2,697
VEGF and the quest for tumour angiogenesis factors
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Self-citationRole of vascular endothelial growth factor in regulation of physiological angiogenesis
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Self-citationOsteogenesis and angiogenesis: The potential for engineering bone
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Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis
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VEGFA is necessary for chondrocyte survival during bone development
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Self-citationA field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
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The cartilage extracellular matrix as a transient developmental scaffold for growth plate maturation
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Metadata
- Authors
- Haigh, J. J., Gerber, H.-P., Ferrara, N., & Wagner, E. F.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-04-01
- Volume
- 127
- Issue
- 7
- Pages
- 1445-1453
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2102911949
- Cited by
- 192
- References
- 3
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
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