The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Zebrafish smoothened functions in ventral neural tube specification and axon tract formation
Abstract
Sonic hedgehog (Shh) signaling patterns many vertebrate tissues. shh mutations dramatically affect mouse ventral forebrain and floor plate but produce minor defects in zebrafish. Zebrafish have two mammalian Shh orthologs, sonic hedgehog and tiggy-winkle hedgehog, and another gene, echidna hedgehog, that could have overlapping functions. To examine the role of Hedgehog signaling in zebrafish, we have characterized slow muscle omitted (smu) mutants. We show that smu encodes a zebrafish ortholog of Smoothened that transduces Hedgehog signals. Zebrafish smoothened is expressed maternally and zygotically and supports specification of motoneurons, pituitary cells and ventral forebrain. We propose that smoothened is required for induction of lateral floor plate and a subpopulation of hypothalamic cells and for maintenance of medial floor plate and hypothalamic cells.
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A leisurely look at the bootstrap, the jackknife, and cross-validation
Efron, B., & Gong, G. (1983) · The American Statistician · doi:10.1080/00031305.1983.10483087 · Cited by 3,229
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish
Schauerte, H. E., Eeden, F. J. M. V., Fricke, C., Odenthal, J., Strähle, U., & Haffter, P. (1998) · Development · doi:10.1242/dev.125.15.2983 · Cited by 349
Barth, K. A., & Wilson, S. W. (1995) · Development · doi:10.1242/dev.121.6.1755 · Cited by 332
Cited by
Vertebrate Smoothened functions at the primary cilium
Corbit, K. C., Aanstad, P., Singla, V., Norman, A. R., Stainier, D. Y. R., & Reiter, J. F. (2005) · Nature · doi:10.1038/nature04117 · Cited by 1,481
The genomic signature of dog domestication reveals adaptation to a starch-rich diet
Axelsson, E., Ratnakumar, A., Arendt, M.-L., Maqbool, K., Webster, M. T., Perloski, M., Liberg, O., Arnemo, J. M., Hedhammar, Å., & Lindblad-Toh, K. (2013) · Nature · doi:10.1038/nature11837 · Cited by 963
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Mechanisms and functions of Hedgehog signalling across the metazoa
Ingham, P. W., Nakano, Y., & Seger, C. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2984 · Cited by 605
Foxj1 transcription factors are master regulators of the motile ciliogenic program
Yu, X., Ng, C. P., Habacher, H., & Roy, S. (2008) · Nature Genetics · doi:10.1038/ng.263 · Cited by 495
Metadata
- Authors
- Varga, Z. M., Amores, A., Lewis, K. E., Yan, Y.-L., Postlethwait, J. H., Eisen, J. S., & Westerfield, M.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-09-15
- Volume
- 128
- Issue
- 18
- Pages
- 3497-3509
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2166557407
- Cited by
- 290
- References
- 3
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Varga, Z. M., Amores, A., Lewis, K. E., Yan, Y.-L., Postlethwait, J. H., Eisen, J. S., & Westerfield, M. (2001). Zebrafish smoothened functions in ventral neural tube specification and axon tract formation. Development. https://doi.org/10.1242/dev.128.18.3497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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