The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis
Open accessAbstract
The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effect, but inactivating two or more genes perturbed both axon outgrowth and guidance. mig-2 and ced-10 also have redundant functions in some cell migrations. By contrast, ced-10 is uniquely required for cell-corpse phagocytosis, and mig-2 and rac-2 have only subtle roles in this process. Rac activators are also used differentially. The UNC-73 Trio Rac GTP exchange factor affected all Rac pathways in axon pathfinding and cell migration but did not affect cell-corpse phagocytosis. CED-5 DOCK180, which acts with CED-10 Rac in cell-corpse phagocytosis, acted with MIG-2 but not CED-10 in axon pathfinding. Thus, distinct regulatory proteins modulate Rac activation and function in different developmental processes.
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Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A., Xu, S., Montgomery, M. K., Kostas, S. A., Driver, S. E., & Mello, C. C. (1998) · Nature · doi:10.1038/35888 · Cited by 15,429
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
The GTPase superfamily: conserved structure and molecular mechanism
Bourne, H. R., Sanders, D. A., & McCormick, F. (1991) · Nature · doi:10.1038/349117a0 · Cited by 3,392
Characterization of RAC3, a Novel Member of the Rho Family
Haataja, L., Groffen, J., & Heisterkamp, N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.33.20384 · Cited by 243
Cited by
Etienne-Manneville, S., & Hall, A. (2002) · Nature · doi:10.1038/nature01148 · Cited by 4,201
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk, S. F., Tosello-Trampont, A.-C., Macara, I. G., Madhani, H., Fink, G. R., & Ravichandran, K. S. (2002) · Nature Cell Biology · doi:10.1038/ncb824 · Cited by 576
Dong, Y., Taylor, H. E., & Dimopoulos, G. (2006) · PLoS Biology · doi:10.1371/journal.pbio.0040229 · Cited by 465
Evolution of the Rho Family of Ras-Like GTPases in Eukaryotes
Boureux, A., Vignal, E., Faure, S., & Fort, P. (2007) · Molecular Biology and Evolution · doi:10.1093/molbev/msl145 · Cited by 447
Rho and Ras GTPases in axon growth, guidance, and branching
Hall, A., & Lalli, G. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001818 · Cited by 437
Rac GTPases control axon growth, guidance and branching
Ng, J., Nardine, T., Harms, M., Tzu, J., Goldstein, A., Sun, Y., Dietzl, G., Dickson, B. J., & Luo, L. (2002) · Nature · doi:10.1038/416442a · Cited by 340
Biomechanical regulation of contractility: spatial control and dynamics
Levayer, R., & Lecuit, T. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.10.001 · Cited by 324
Regulation of actin dynamics by WASP and WAVE family proteins
Stradal, T. E. B., Rottner, K., Disanza, A., Confalonieri, S., Innocenti, M., & Scita, G. (2004) · Trends in Cell Biology · doi:10.1016/j.tcb.2004.04.007 · Cited by 286
Two pathways converge at CED-10 to mediate actin rearrangement and corpse removal in C. elegans
Kinchen, J. M., Cabello, J., Klingele, D., Wong, K., Feichtinger, R., Schnabel, H., Schnabel, R., & Hengartner, M. O. (2005) · Nature · doi:10.1038/nature03263 · Cited by 268
Grimsley, C. M., Kinchen, J. M., Tosello-Trampont, A.-C., Brugnera, E., Haney, L. B., Lu, M., Chen, Q., Klingele, D., Hengartner, M. O., & Ravichandran, K. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m307087200 · Cited by 224
Miyamoto, Y., Torii, T., Yamamori, N., Ogata, T., Tanoue, A., & Yamauchi, J. (2013) · Science Signaling · doi:10.1126/scisignal.2003661 · Cited by 61
Metadata
- Authors
- Lundquist, E. A., Reddien, P. W., Hartwieg, E., Horvitz, H. R., & Bargmann, C. I.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-11-15
- Volume
- 128
- Issue
- 22
- Pages
- 4475-4488
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2120879594
- Cited by
- 242
- References
- 5
- FWCI
- 5.22
- Type
- journal article
- Language
- en
- Open access
- green
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