The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Gli1 can rescue the in vivo function of Gli2
Abstract
In mice, three Gli genes are thought to mediate sonic hedgehog (Shh) signaling collectively. Mis-expression studies and analysis of null mutants for each gene have indicated that the Gli proteins have different functions. In particular, Gli1 appears to be a constitutive activator, and Gli2 and Gli3 have repressor functions. To determine the precise functional differences between Gli1 and Gli2, we have expressed Gli1 in place of Gli2 from the endogenous Gli2 locus in mice. Strikingly, a low level of Gli1 can rescue all the Shh signaling defects in Gli2 mutants; however, only in the presence of a wild-type Shh gene. These studies demonstrate that only the activator function of Gli2 is actually required, and indicates that in specific situations, Shh can modulate the ability of Gli1 to activate target genes. Furthermore, expression of both copies of Gli1 in place of Gli2 does not disrupt spinal cord patterning, but does result in new gain-of-function defects that lead to lethality. We show that the defects are enhanced when Gli3 function is reduced, demonstrating that an important difference between Gli1 and Gli2 is the ability of Gli1 to antagonize Gli3 function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Wang, B., Fallon, J. F., & Beachy, P. A. (2000) · Cell · doi:10.1016/s0092-8674(00)80678-9 · Cited by 1,014
Sasaki, H., Nishizaki, Y., Hui, C.-C., Nakafuku, M., & Kondoh, H. (1999) · Development · doi:10.1242/dev.126.17.3915 · Cited by 715
Cited by
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway
Bai, C. B., Auerbach, W., Lee, J. S., Stephen, D., & Joyner, A. L. (2002) · Development · doi:10.1242/dev.129.20.4753 · Cited by 692
Self-citationMukhopadhyay, S., Wen, X., Ratti, N., Loktev, A., Rangell, L., Scales, S. J., & Jackson, P. K. (2013) · Cell · doi:10.1016/j.cell.2012.12.026 · Cited by 486
Kenney, A. M., Cole, M. D., & Rowitch, D. H. (2003) · Development · doi:10.1242/dev.00182 · Cited by 477
Bai, C. B., Stephen, D., & Joyner, A. L. (2004) · Developmental Cell · doi:10.1016/s1534-5807(03)00394-0 · Cited by 440
Self-citationIntraflagellar transport is essential for endochondral bone formation
Haycraft, C. J., Zhang, Q., Song, B., Jackson, W. S., Detloff, P. J., Serra, R., & Yoder, B. K. (2007) · Development · doi:10.1242/dev.02732 · Cited by 408
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
Fuccillo, M., Joyner, A. L., & Fishell, G. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1990 · Cited by 405
Self-citationChen, M.-H., Wilson, C. W., Li, Y.-J., Law, K. K. L., Lu, C.-S., Gacayan, R., Zhang, X., Hui, C.-C., & Chuang, P.-T. (2009) · Genes & Development · doi:10.1101/gad.1794109 · Cited by 353
Roessler, E., Du, Y.-Z., Mullor, J. L., Casas, E., Allen, W. P., Gillessen-Kaesbach, G., Roeder, E. R., Ming, J. E., Altaba, A. R. I., & Muenke, M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235734100 · Cited by 349
Dorsal-ventral patterning of the spinal cord requires Gli3 transcriptional repressor activity
Persson, M., Stamataki, D., te Welscher, P., Andersson, E., Böse, J., Rüther, U., Ericson, J., & Briscoe, J. (2002) · Genes & Development · doi:10.1101/gad.243402 · Cited by 306
A gradient of Gli activity mediates graded Sonic Hedgehog signaling in the neural tube
Stamataki, D., Ulloa, F., Tsoni, S. V., Mynett, A., & Briscoe, J. (2005) · Genes & Development · doi:10.1101/gad.325905 · Cited by 262
G-protein-coupled receptors, Hedgehog signaling and primary cilia
Mukhopadhyay, S., & Rohatgi, R. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.05.002 · Cited by 142
The emergent design of the neural tube: prepattern, SHH morphogen and GLI code
Ruiz i Altaba, A., Nguyên, V., & Palma, V. (2003) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2003.08.005 · Cited by 118
Spop promotes skeletal development and homeostasis by positively regulating Ihh signaling
Cai, H., & Liu, A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612520114 · Cited by 67
Hwang, S., & Mukhopadhyay, S. (2015) · Birth Defects Research Part A: Clinical and Molecular Teratology · doi:10.1002/bdra.23267 · Cited by 20
Metadata
- Authors
- Bai, C. B., & Joyner, A. L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2001-12-15
- Volume
- 128
- Issue
- 24
- Pages
- 5161-5172
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2127472285
- Cited by
- 291
- References
- 3
- FWCI
- 4.34
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
