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Notch1 is required for neuronal and glial differentiation in the cerebellum
Open accessAbstract
The mechanisms that guide progenitor cell fate and differentiation in the vertebrate central nervous system (CNS) are poorly understood. Gain-of-function experiments suggest that Notch signaling is involved in the early stages of mammalian neurogenesis. On the basis of the expression of Notch1 by putative progenitor cells of the vertebrate CNS, we have addressed directly the role of Notch1 in the development of the mammalian brain. Using conditional gene ablation, we show that loss of Notch1 results in premature onset of neurogenesis by neuroepithelial cells of the midbrain-hindbrain region of the neural tube. Notch1-deficient cells do not complete differentiation but are eliminated by apoptosis, resulting in a reduced number of neurons in the adult cerebellum. We have also analyzed the effects of Notch1 ablation on gliogenesis in vivo. Our results show that Notch1 is required for both neuron and glia formation and modulates the onset of neurogenesis within the cerebellar neuroepithelium.
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Cited by
Lugert, S., Basak, O., Knuckles, P., Haussler, U., Fabel, K., Götz, M., Haas, C. A., Kempermann, G., Taylor, V., & Giachino, C. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.03.017 · Cited by 704
Self-citationNotch mediates TGFα-induced changes in epithelial differentiation during pancreatic tumorigenesis
Miyamoto, Y., Maitra, A., Ghosh, B., Zechner, U., Argani, P., Iacobuzio-Donahue, C. A., Sriuranpong, V., Iso, T., Meszoely, I. M., Wolfe, M. S., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00140-5 · Cited by 643
Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
Shi, S., & Stanley, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831126100 · Cited by 381
Robins, S. C., Stewart, I., McNay, D. E., Taylor, V., Giachino, C., Goetz, M., Ninkovic, J., Briancon, N., Maratos-Flier, E., Flier, J. S., et al. (2013) · Nature Communications · doi:10.1038/ncomms3049 · Cited by 306
Self-citationStem cells living with a Notch
Koch, U., Lehal, R., & Radtke, F. (2013) · Development · doi:10.1242/dev.080614 · Cited by 283
Self-citationSathyan, P., Golden, H. B., & Miranda, R. C. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.1269-07.2007 · Cited by 278
Notch1 control of oligodendrocyte differentiation in the spinal cord
Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S. S., Suter, U., Nave, K.-A., & Mantei, N. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202002 · Cited by 211
Self-citationLiu, W., Li, R., Yin, J., Guo, S., Chen, Y., Fan, H., Li, G., Li, Z., Li, X., Zhang, X., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1396-5 · Cited by 80
Metadata
- Authors
- Lütolf, S., Radtke, F., Aguet, M., Suter, U., & Taylor, V.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-01-15
- Volume
- 129
- Issue
- 2
- Pages
- 373-385
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2139733283
- Cited by
- 264
- References
- 0
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- green
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