A transcriptional profile of multicellular development in Dictyostelium discoideum
Abstract
A distinct feature of development in the simple eukaryote Dictyostelium discoideum is an aggregative transition from a unicellular to a multicellular phase. Using genome-wide transcriptional analysis we show that this transition is accompanied by a dramatic change in the expression of more than 25% of the genes in the genome. We also show that the transcription patterns of these genes are not sensitive to the strain or the nutritional history, indicating that Dictyostelium development is a robust physiological process that is accompanied by stereotypical transcriptional events. Analysis of the two differentiated cell types, spores and stalk cells, and their precursors revealed a large number of differentially expressed genes as well as unexpected patterns of gene expression, which shed new light on the timing and possible mechanisms of cell-type divergence. Our findings provide new perspectives on the complexity of the developmental program and the fraction of the genome that is regulated during development. Supplemental data available on-line
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Microarrays have already been used in Dictyostelium to study regulatory pathways during development or host cell response during Legionella infection.
“Microarrays have been already used in Dictyostelium to study regulatory pathways during development [29-31] or host cell response during Legionella infection [32].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [29]
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- Authors
- Van Driessche, N., Shaw, C., Katoh, M., Morio, T., Sucgang, R., Ibarra, M., Kuwayama, H., Saito, T., Urushihara, H., Maeda, M., Takeuchi, I., Ochiai, H., Eaton, W., Tollett, J., Halter, J., Kuspa, A., Tanaka, Y., & Shaulsky, G.
- Affiliations
- Department of Molecular and Human Genetics,
- Institute of Biological Sciences, University of Tsukuba, Tsukuba, Japan
- University of Tsukuba (JP)
- Department of Biochemistry and Molecular Biology,
- Hokkaido University (JP)
- The University of Osaka (JP)
- NOVARTIS Foundation for the Promotion of Science (Japan) (JP)
- Baylor College of Medicine (US)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2002-04-01
- Volume
- 129
- Issue
- 7
- Pages
- 1543-1552
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2156690217
- Cited by
- 130
- References
- 60
- Citations by year
- 2026: 2 · 2024: 2 · 2021: 2 · 2020: 2 · 2019: 5 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD039691, P01 HD39691-01)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Physical Sciences › Engineering › Biomedical Engineering › Slime Mold and Myxomycetes Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Planarian Biology and Electrostimulation
- Keywords
- Dictyostelium discoideum, multicellular development, gene expression profiling, aggregation, spores, stalk cells, cell differentiation, differentially expressed genes, developmental gene regulation, nutritional history
- MeSH terms
- Animals, Dictyostelium, Transcription, Genetic, Reproducibility of Results, Genome, Protozoan, Gene Expression Regulation, Developmental, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling
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