The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Using brain organoids to understand Zika virus-induced microcephaly
Open accessAbstract
Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble in vivo organs are pushing the frontiers of human disease modeling and drug development. In response to the global health emergency posed by the Zika virus (ZIKV) outbreak, brain organoids engineered to mimic the developing human fetal brain have been employed to model ZIKV-induced microcephaly. Here, we discuss the advantages of brain organoids over other model systems to study development and highlight recent advances in understanding ZIKV pathophysiology and its underlying pathogenesis mechanisms. We further discuss perspectives on overcoming limitations of current organoid systems for their future use in ZIKV research.
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Cites
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Cited by
Hofer, M., & Lutolf, M. P. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00279-y · Cited by 1,184
Brain organoids: advances, applications and challenges
Qian, X., Song, H., & Ming, G.-L. (2019) · Development · doi:10.1242/dev.166074 · Cited by 724
Self-citationThe hope and the hype of organoid research
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Towards organoid culture without Matrigel
Kozlowski, M. T., Crook, C. J., & Ku, H. T. (2021) · Communications Biology · doi:10.1038/s42003-021-02910-8 · Cited by 409
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Metadata
- Authors
- Qian, X., Nguyen, H. N., Jacob, F., Song, H., & Ming, G.-L.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2017-03-15
- Volume
- 144
- Issue
- 6
- Pages
- 952-957
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2602914633
- Cited by
- 240
- References
- 15
- FWCI
- 24.27
- Type
- journal article
- Language
- en
- Open access
- green
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