Cited by 93Flavonoids in Medical ResearchPhytochemicals and Antioxidant ActivitiesBioactive Compounds in Plants

Myricetin: Targeting signaling networks in cancer and its implication in chemotherapy

Open access
Javed, Zeeshan, Khan, Khushbukhat, Herrera-Bravo, Jesús, Naeem, Sajid, Iqbal, Muhammad Javed, Raza, Qamar, Sadia, Haleema, Raza, Shahid +4 more·2022·Cancer Cell International

Abstract

The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into the mysteries of tumor heterogeneity and the molecular framework of tumor cells, therapy resistance and adverse side effects of current therapeutic remain the major challenge. This has shifted the attention towards therapeutics with less toxicity and high efficacy. Myricetin a natural flavonoid has been under the spotlight for its anti-cancer, anti-oxidant, and anti-inflammatory properties. The cutting-edge molecular techniques have shed light on the interplay between myricetin and dysregulated signaling cascades in cancer progression, invasion, and metastasis. However, there are limited data available regarding the nano-delivery platforms composed of myricetin in cancer. In this review, we have provided a comprehensive detail of myricetin-mediated regulation of different cellular pathways, its implications in cancer prevention, preclinical and clinical trials, and its current available nano-formulations for the treatment of various cancers.

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Authors
Javed, Z., Khan, K., Herrera-Bravo, J., Naeem, S., Iqbal, M. J., Raza, Q., Sadia, H., Raza, S., Bhinder, M., Calina, D., Sharifi-Rad, J., & Cho, W. C.
Affiliations
  • Lahore Garrison University (PK)
  • National University of Sciences and Technology (PK)
  • Lanzhou University (CN)
  • University of Sialkot (PK)
  • University of Veterinary and Animal Sciences (PK)
  • Balochistan University of Information Technology, Engineering and Management Sciences (PK)
  • University of Health Sciences Lahore (PK)
  • Queen Elizabeth Hospital (CN)
Corresponding author
  • Iqbal, Muhammad Javed
  • Cho, William C.
Venue
Cancer Cell International
Published
2022-07-28
Volume
22
Issue
1
Pages
239-239
ISSN
1475-2867 (ISSN-L)
OpenAlex
W4288447024
Cited by
93
References
126
Citations by year
2026: 11 · 2025: 24 · 2024: 13 · 2023: 33 · 2022: 12
FWCI
2.95
Type
journal article
Language
en
Open access
Locations
  • Cancer Cell International (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Greater South Information System
Topics
  • Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Bioactive Compounds in Plants
Keywords
myricetin, flavonoids, cancer pathways, chemoresistance, metastasis, cancer prevention, nano-delivery systems, nanoformulations, anti-inflammatory activity, antioxidant activity, clinical trials

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