Myricetin: Targeting signaling networks in cancer and its implication in chemotherapy
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The gaps between the complex nature of cancer and therapeutics have been narrowed down due to extensive research in molecular oncology. Despite gathering massive insight into the mysteries of tumor heterogeneity and the molecular framework of tumor cells, therapy resistance and adverse side effects of current therapeutic remain the major challenge. This has shifted the attention towards therapeutics with less toxicity and high efficacy. Myricetin a natural flavonoid has been under the spotlight for its anti-cancer, anti-oxidant, and anti-inflammatory properties. The cutting-edge molecular techniques have shed light on the interplay between myricetin and dysregulated signaling cascades in cancer progression, invasion, and metastasis. However, there are limited data available regarding the nano-delivery platforms composed of myricetin in cancer. In this review, we have provided a comprehensive detail of myricetin-mediated regulation of different cellular pathways, its implications in cancer prevention, preclinical and clinical trials, and its current available nano-formulations for the treatment of various cancers.
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Incorporating bioactive molecules into nanoparticles is a strategy that allows overcoming various physicochemical limitations of the drug.
“For this reason, incorporating bioactive molecules into nanoparticles is a strategy that allows for overcoming various physicochemical limitations of the drug [203,209].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [203]
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Flagged first, then by citations
Cited by
Sorted by citations
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
Self-citation
- Authors
- Javed, Z., Khan, K., Herrera-Bravo, J., Naeem, S., Iqbal, M. J., Raza, Q., Sadia, H., Raza, S., Bhinder, M., Calina, D., Sharifi-Rad, J., & Cho, W. C.
- Affiliations
- Lahore Garrison University (PK)
- National University of Sciences and Technology (PK)
- Lanzhou University (CN)
- University of Sialkot (PK)
- University of Veterinary and Animal Sciences (PK)
- Balochistan University of Information Technology, Engineering and Management Sciences (PK)
- University of Health Sciences Lahore (PK)
- Queen Elizabeth Hospital (CN)
- Corresponding author
- Iqbal, Muhammad Javed
- Cho, William C.
- ORCID
- Venue
- Cancer Cell International
- Published
- 2022-07-28
- Volume
- 22
- Issue
- 1
- Pages
- 239-239
- ISSN
- 1475-2867 (ISSN-L)
- PMC
- PMC9336020
- OpenAlex
- W4288447024
- Cited by
- 93
- References
- 126
- Citations by year
- 2026: 11 · 2025: 24 · 2024: 13 · 2023: 33 · 2022: 12
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cancer Cell International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Greater South Information System
- Topics
- Health Sciences › Medicine › Pharmacology › Flavonoids in Medical Research
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Bioactive Compounds in Plants
- Keywords
- myricetin, flavonoids, cancer pathways, chemoresistance, metastasis, cancer prevention, nano-delivery systems, nanoformulations, anti-inflammatory activity, antioxidant activity, clinical trials
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