The DOI matches its Crossref record; 111 of the 114 references it cites were found in a registry or an index.
The pathophysiology of traumatic brain injury at a glance
Open accessAbstract
Summary: Traumatic brain injury (TBI) is defined as an impact, penetration or rapid movement of the brain within the skull that results in altered mental state. TBI occurs more than any other disease, including breast cancer, AIDS, Parkinson’s disease and multiple sclerosis, and affects all age groups and both genders. In the US and Europe, the magnitude of this epidemic has drawn national attention owing to the publicity received by injured athletes and military personnel. This increased public awareness has uncovered a number of unanswered questions concerning TBI, and we are increasingly aware of the lack of treatment options for a crisis that affects millions. Although each case of TBI is unique and affected individuals display different degrees of injury, different regional patterns of injury and different recovery profiles, this review and accompanying poster aim to illustrate some of the common underlying neurochemical and metabolic responses to TBI. Recognition of these recurrent features could allow elucidation of potential therapeutic targets for early intervention.
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“We counted brainstem neurons in a blinded manner using the same stereological procedures as previously described.9”
From Damage to Arousal-Promoting Brainstem Neurons with Traumatic Brain Injury (2016) · cites this paper as [9]
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“Additional factors that may protect the brainstem include lower metabolic requirements and a blood supply less likely to be damaged by direct traumatic forces.9”
From Damage to Arousal-Promoting Brainstem Neurons with Traumatic Brain Injury (2016) · cites this paper as [9]
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Madhusankha, K. H. D., Dissanayaka, D., Rathnayaka, D., & Bandara, S. (2021) · Journal of Neurology Research Review & Reports · doi:10.47363/jnrrr/2021(3)148
“International Journal of Innovative Surgery Traumatic brain injury is defined as an impact penetration or rapid movement of the brain within the skull results in altered mental state [5].”
BackgroundChemo-Mechanical Regulation of Tau Phosphorylation Following Traumatic Brain InjuriesPreprint
Kant, A., Medhekar, N. V., & Bhandakkar, T. K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.13.548916
Efficacy of Glasgow Coma Scale in Assessing the Outcome of Patients with Head Injury
Agnihotri, A., & Chandel, U. K. (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i05.6213
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“We chose to model TBI as a process to reflect the evolution of injury over primary and secondary phases (Prins et al. 2013; Werner and Engelhard 2007).”
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Ismail, H. (2023) · doi:10.29086/10413/22615
Drug Delivery Strategies in Traumatic Brain Injury
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Neurological and Neuropsychiatric Disorders Affecting Military Personnel and Veterans
(2024) · Frontiers research topics · doi:10.3389/978-2-8325-4656-7
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AI-Powered Detection and Rehabilitation Support for Brain Wellness
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Traumatic Brain Injury Causes Endothelial Dysfunction In Mesenteric Arteries 24 Hrs After Injury
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Metadata
- Authors
- Prins, M., Greco, T., Alexander, D., & Giza, C. C.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Prins, Mayumi
- Venue
- Disease Models & Mechanisms
- Publisher
- The Company of Biologists
- Published
- 2013-01-01
- Volume
- 6
- Issue
- 6
- Pages
- 1307-15
- ISSN
- 1754-8403 (ISSN-L)
- 1754-8411
- PMC
- PMC3820255
- OpenAlex
- W2141923055
- Cited by
- 426
- References
- 114
- Citations by year
- 2026: 7 · 2025: 29 · 2024: 37 · 2023: 40 · 2022: 41 · 2021: 55 · 2020: 55 · 2019: 40 · 2018: 46 · 2017: 27 · 2016: 14 · 2015: 24 · 2014: 8 · 2013: 3
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Disease Models & Mechanisms (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-058489, P01NS058489)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
- Keywords
- traumatic brain injury, pathophysiology, brain metabolism, altered mental status, injury patterns, recovery profiles, therapeutic target, TBI epidemiology
- MeSH terms
- Brain, Brain Injuries, Free Radicals, Glucose, Humans, Mitochondria
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