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Cited by 437

The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.

Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors

Open access
Zhao, Min, Bai, Huai, Wang, Entong, Forrester, John V., McCaig, Colin D.·2004·Journal of Cell Science
DOI 10.1242/jcs.00868
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Abstract

Controlling angiogenesis is crucial. Growth factors and cytokines are key regulators but a full understanding remains elusive. Endogenous electrical potential differences exist within and around the vasculature, both in relation to blood flow and in situations where active angiogenesis occurs, such as wound healing, development and tumor growth. Recent work shows that electrical stimulation induces significant angiogenesis in vivo, through enhanced vascular endothelial growth factor (VEGF) production by muscle cells. We report that applied electric fields (EFs) of small physiological magnitude directly stimulate VEGF production by endothelial cells in culture without the presence of any other cell type. EFs as low as 75-100 mV mm–1 (1.5-2.0 mV across an endothelial cell) directed the reorientation, elongation and migration of endothelial cells in culture. These pre-angiogenic responses required VEGF receptor activation and were mediated through PI3K-Akt and Rho-ROCK signaling pathways, resulting in reorganization of the actin cytoskeleton. This indicates that endogenous EFs might play a role in angiogenesis in vivo by stimulating the VEGF receptor signaling pathway, to induce key pre-angiogenic responses. In addition, it raises the feasibility of using applied EFs to initiate and guide angiogenesis through direct effects on endothelial cells.

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Metadata

Authors
Zhao, M., Bai, H., Wang, E., Forrester, J. V., & McCaig, C. D.
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2004-01-22
Volume
117
Issue
3
Pages
397-405
ISSN
  • 0021-9533 (ISSN-L)
  • 1477-9137
DOI
10.1242/jcs.00868
OpenAlex
W1992354853
Cited by
437
References
40
FWCI
1.39
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. https://app.cochat.ai/papers/10.1242/jcs.00868
The paper
Zhao, M., Bai, H., Wang, E., Forrester, J. V., & McCaig, C. D. (2004). Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. Journal of Cell Science. https://doi.org/10.1242/jcs.00868

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.