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Molecular mechanisms of E2F-dependent activation and pRB-mediated repression

Frolov, Maxim V., Dyson, Nicholas J.·2004·Journal of Cell Science
DOI 10.1242/jcs.01227
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Abstract

Alterations in transcription of genes regulated by members of the E2F family of transcription factors can be viewed as a measure of the ebb and flow in a constantly evolving battle between repressor and activator complexes. Various chromatin regulatory complexes have been linked to Rb/E2F proteins, and changes in histone modifications correlate with states of E2F-dependent transcription. E2F has traditionally been viewed in the context of cell-cycle control. However, several recent studies have revealed a new aspect of E2F function in which pRB/E2F-family proteins confer stable repression of transcription. Such repression is evident in both actively proliferating cells and in cells that have withdrawn from the cell cycle.

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Metadata

Authors
Frolov, M. V., & Dyson, N. J.
Affiliations
Massachusetts General Hospital Cancer Center, Bldg 149, 13th Street, Charlestown, MA 02129, USA
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2004-05-01
Volume
117
Issue
11
Pages
2173-2181
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.01227
Cited by
338
References
6
Language
en

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