The DOI matches its Crossref record; 164 of the 164 references it cites were found in a registry or an index.
Linking JNK signaling to NF-κB: a key to survival
Abstract
In addition to marshalling immune and inflammatory responses, transcription factors of the NF-κB family control cell survival. This control is crucial to a wide range of biological processes, including B and T lymphopoiesis, adaptive immunity, oncogenesis and cancer chemoresistance. During an inflammatory response, NF-κB activation antagonizes apoptosis induced by tumor necrosis factor (TNF)-α, a protective activity that involves suppression of the Jun N-terminal kinase (JNK) cascade. This suppression can involve upregulation of the Gadd45-family member Gadd45β/Myd118, which associates with the JNK kinase MKK7/JNKK2 and blocks its catalytic activity. Upregulation of XIAP, A20 and blockers of reactive oxygen species (ROS) appear to be important additional means by which NF-κB blunts JNK signaling. These recent findings might open up entirely new avenues for therapeutic intervention in chronic inflammatory diseases and certain cancers; indeed, the Gadd45β-MKK7 interaction might be a key target for such intervention.
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Cites
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Cited by
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
Bedard, K., & Krause, K.-H. (2007) · Physiological Reviews · doi:10.1152/physrev.00044.2005 · Cited by 6,989
NF-κB, inflammation, immunity and cancer: coming of age
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Crosstalk in NF-κB Signaling Pathways
Oeckinghaus, A., Hayden, M. S., & Ghosh, S. (2011) · Nature Immunology · doi:10.1038/ni.2065 · Cited by 1,942
Karki, R., Sharma, B. R., Tuladhar, S., Williams, E. P., Zalduondo, L., Samir, P., Zheng, M., Sundaram, B., Banoth, B., Malireddi, R. K. S., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.025 · Cited by 1,734
Chang, L., Kamata, H., Solinas, G., Luo, J.-L., Maeda, S., Venuprasad, K., Liu, Y.-C., & Karin, M. (2006) · Cell · doi:10.1016/j.cell.2006.01.021 · Cited by 706
Metadata
- Authors
- Papa, S., Zazzeroni, F., Pham, C. G., Bubici, C., & Franzoso, G.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2004-10-15
- Volume
- 117
- Issue
- 22
- Pages
- 5197-5208
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1995335649
- Cited by
- 276
- References
- 164
- FWCI
- 9.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Papa, S., Zazzeroni, F., Pham, C. G., Bubici, C., & Franzoso, G. (2004). Linking JNK signaling to NF-κB: a key to survival. Journal of Cell Science. https://doi.org/10.1242/jcs.01483
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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