The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
CZH proteins: a new family of Rho-GEFs
Abstract
The Rho family of small GTPases are important regulators of multiple cellular activities and, most notably, reorganization of the actin cytoskeleton. Dbl-homology (DH)-domain-containing proteins are the classical guanine nucleotide exchange factors (GEFs) responsible for activation of Rho GTPases. However, members of a newly discovered family can also act as Rho-GEFs. These CZH proteins include: CDM (Ced-5, Dock180 and Myoblast city) proteins, which activate Rac; and zizimin proteins, which activate Cdc42. The family contains 11 mammalian proteins and has members in many other eukaryotes. The GEF activity is carried out by a novel, DH-unrelated domain named the DOCKER, CZH2 or DHR2 domain. CZH proteins have been implicated in cell migration, phagocytosis of apoptotic cells, T-cell activation and neurite outgrowth, and probably arose relatively early in eukaryotic evolution.
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Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
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Rho GTPases: functions and association with cancer
Ellenbroek, S. I. J., & Collard, J. G. (2007) · Clinical & Experimental Metastasis · doi:10.1007/s10585-007-9119-1 · Cited by 289
Cell Polarity Signaling in Arabidopsis
Yang, Z. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.23.090506.123233 · Cited by 269
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Metadata
- Authors
- Meller, N., Merlot, S., & Guda, C.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2005-11-01
- Volume
- 118
- Issue
- 21
- Pages
- 4937-4946
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2025896887
- Cited by
- 277
- References
- 86
- FWCI
- 7.38
- Type
- journal article
- Language
- en
- Open access
- closed
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