The DOI matches its Crossref record; 115 of the 115 references it cites were found in a registry or an index.
Cytoskeletal dynamics in growth-cone steering
Open accessAbstract
Interactions between dynamic microtubules and actin filaments are essential to a wide range of cell biological processes including cell division, motility and morphogenesis. In neuronal growth cones, interactions between microtubules and actin filaments in filopodia are necessary for growth cones to make a turn. Growth-cone turning is a fundamental behaviour during axon guidance, as correct navigation of the growth cone through the embryo is required for it to locate an appropriate synaptic partner. Microtubule-actin filament interactions also occur in the transition zone and central domain of the growth cone, where actin arcs exert compressive forces to corral microtubules into the core of the growth cone and thereby facilitate microtubule bundling, a requirement for axon formation. We now have a fairly comprehensive understanding of the dynamic behaviour of the cytoskeleton in growth cones, and the stage is set for discovering the molecular machinery that enables microtubule-actin filament coupling in growth cones, as well as the intracellular signalling pathways that regulate these interactions. Furthermore, recent experiments suggest that microtubule-actin filament interactions might also be important for the formation of dendritic spines from filopodia in mature neurons. Therefore, the mechanisms coupling microtubules to actin filaments in growth-cone turning and dendritic-spine maturation might be conserved.
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Cites
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GSK-3β Regulates Phosphorylation of CRMP-2 and Neuronal Polarity
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Elie, A., Prezel, E., Guérin, C., Denarier, E., Ramirez-Rios, S., Serre, L., Andrieux, A., Fourest-Lieuvin, A., Blanchoin, L., & Arnal, I. (2015) · Scientific Reports · doi:10.1038/srep09964 · Cited by 200
Dock GEFs and their therapeutic potential: Neuroprotection and axon regeneration
Namekata, K., Kimura, A., Kawamura, K., Harada, C., & Harada, T. (2014) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2014.06.005 · Cited by 57
Wei, Z., Sun, M., Liu, X., Zhang, J., & Jin, Y. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12740 · Cited by 39
Visualising the cytoskeletal machinery in neuronal growth cones using cryo-electron tomography
Atherton, J., Stouffer, M., Francis, F., & Moores, C. A. (2022) · Journal of Cell Science · doi:10.1242/jcs.259234 · Cited by 34
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Metadata
- Authors
- Geraldo, S., & Gordon-Weeks, P. R.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2009-10-15
- Volume
- 122
- Issue
- 20
- Pages
- 3595-3604
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2141734192
- Cited by
- 257
- References
- 115
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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