The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord
Abstract
The action of lysophosphatidyl choline, LPC, on myelinated fibres in the dorsal white matter of the spinal cord of the adult mouse has been studied electron microscopically, and compared with the recently described activity of LPC in the peripheral nerve fibre. Control injections of sterile isotonic saline and injections of LPC both produced oedematous zones in the white matter; within these zones, many fibres exhibited the characteristic changes of Wallerian degeneration. After injection of LPC, however, an area of demyelination was observed, extending within and beyond the Wallerian degeneration. Ultrastructurally, demyelination involved progressive disruption of the previously-compact sheath, observed initially as a splitting of the intraperiod line within 30 min. Subsequent breakdown was-indicated by the appearance of strands of 4-6 nm repeat lamellar material, itself further degraded through quintuple- and triple-layered lamellar units to disorganized membranous networks around undamaged axons. The significance of the demyelinating activity of LPC is discussed in terms of its known action in in vitro systems of isolated central nervous tissue, and its action in vivo in the peripheral nervous system.
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Cites
Glial cells and the central myelin sheath.
Bunge, R. P. (1968) · Physiological Reviews · doi:10.1152/physrev.1968.48.1.197 · Cited by 539
LAMPERT, P. W. (1967) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-196707000-00001 · Cited by 387
Hall, S. M., & Gregson, N. A. (1971) · Journal of Cell Science · doi:10.1242/jcs.9.3.769 · Cited by 195
Self-citationLAMPERT, P. W. (1965) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-196507000-00001 · Cited by 165
Fine-structural changes of myelin sheaths after axonal degeneration in the spinal cord of rats.
Lampert, P. W., & Cressman, M. R. (1966) · PubMed · Cited by 128
Ultrastructure of inflammation with edema in the rat brain.
Gonatas, N. K., Zimmerman, H. M., & LEVINE, S. (1963) · PubMed · Cited by 85
The Lipid-Protein Unit in Myelin
Gent, W. L. G., Gregson, N. A., Gammack, D. B., & RAPER, J. H. (1964) · Nature · doi:10.1038/204553a0 · Cited by 83
Clearing Action of Lysolecithin on Brain Homogenates
Webster, G. R. (1957) · Nature · doi:10.1038/180660a0 · Cited by 42
Cited by
Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225
Principles of diffusion tensor imaging and its applications to basic neuroscience research
Mori, S., & Zhang, J. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.012 · Cited by 1,708
Oligodendrocytes in development, myelin generation and beyond
Kuhn, S., Gritti, L., Crooks, D., & Dombrowski, Y. (2019) · Cells · doi:10.3390/cells8111424 · Cited by 625
Regulatory T cells promote myelin regeneration in the central nervous system
Dombrowski, Y., O'Hagan, T., Dittmer, M., Penalva, R., Mayoral, S. R., Bankhead, P., Fleville, S., Eleftheriadis, G., Zhao, C., Naughton, M., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4528 · Cited by 533
Nait‐Oumesmar, B., Decker, L., Lachapelle, F., Avellana‐Adalid, V., Bachelin, C., & Van Evercooren, A. B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00873.x · Cited by 560
Metadata
- Authors
- Hall, S. M.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 1972-03-01
- Volume
- 10
- Issue
- 2
- Pages
- 535-546
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W1889195978
- Cited by
- 274
- References
- 8
- FWCI
- 1.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hall, S. M. (1972). The effect of injections of lysophosphatidyl choline into white matter of the adult mouse spinal cord. Journal of Cell Science. https://doi.org/10.1242/jcs.10.2.535
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
