Septins 2, 7, and 9 and MAP4 co-localize along the axoneme in the primary cilium and control ciliary length
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Septins are a large, evolutionarily conserved family of GTPases that form hetero-oligomers and interact with the actin-based cytoskeleton and microtubules. They are involved in scaffolding functions, and form diffusion barriers in budding yeast, the sperm flagellum and the base of primary cilia of kidney epithelial cells. We investigated the role of septins in the primary cilium of retinal pigmented epithelial (RPE) cells, and found that SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9 and that the three members of this complex colocalize along the length of the axoneme. Similar to observations in kidney epithelial cells, depletion of cilium-localized septins by siRNA-based approaches inhibited ciliogenesis. MAP4, which is a binding partner of SEPT2 and controls the accessibility of septins to microtubules, was also localized to the axoneme where it appeared to negatively regulate ciliary length. Taken together, our data provide new insights into the functions and regulation of septins and MAP4 in the organization of the primary cilium and microtubule-based activities in cells.
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During interphase, the Septin heterotrimer is found in filaments that are recruited to microtubules by MAP-4 rather than Anillin.
“During interphase, the Septin heterotrimer is found in filaments that are recruited to microtubules by microtubule associated protein-4 (MAP-4) [54] rather than Anillin.”
From Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit (2015) · cites this paper as [54]
MAP-4 is responsible for recruiting the Septin complex to the interphase microtubule cytoskeleton.
“MAP-4 is responsible for recruiting the Septin complex to the interphase microtubule cytoskeleton [54].”
From Tumor Treating Fields Perturb the Localization of Septins and Cause Aberrant Mitotic Exit (2015) · cites this paper as [54]
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Uncovering the Roles of Septins in Cilia
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Cancer-Related Functions and Subcellular Localizations of Septins
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In Silico Docking of Forchlorfenuron (FCF) to Septins Suggests that FCF Interferes with GTP Binding
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Phosphoinositide lipids in primary cilia biology
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Phosphorylation of the Usher syndrome 1G protein SANS controls Magi2-mediated endocytosis
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Spatial regulation of microtubule-dependent transport by septin GTPases
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Androglobin, a chimeric mammalian globin, is required for male fertility
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Self-citationPermeability barriers for generating a unique ciliary protein and lipid composition
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Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells
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Tethering of vesicles to the Golgi by GMAP210 controls LAT delivery to the immune synapse
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Septins, a cytoskeletal protein family, with emerging role in striated muscle
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Distinct localization of septin proteins to ciliary sub-compartments in airway epithelial cells
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MAP4 as a New Candidate in Cardiovascular Disease
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Microtubule-associated protein-4 controls nanovesicle dynamics and T cell activation
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The multifaceted roles of microtubule-associated proteins in the primary cilium and ciliopathies
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How do cells know what shape they are?
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Devlin, L., Okletey, J., Perkins, G. L., Bowen, J. R., Νάκος, Κ., Montagna, C., & Spiliotis, E. T. (2021) · PROTEOMICS · doi:10.1002/pmic.202100155 · Cited by 21 · see citing works
Chaudhry, N., Muhammad, H., Seidl, C., Downes, D., Young, D., Hao, Y., Zhu, L.-Y., & Vincent, T. (2022) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2022.01.005 · Cited by 18 · see citing works
Septin-mediated RhoA activation engages the exocyst complex to recruit the cilium transition zone
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Primary cilium-associated genes mediate bone marrow stromal cell response to hypoxia
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Mechanisms of ciliary targeting: entering importins and Rabs
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Functional Characterization of Septin Complexes
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A molecular trap inside microtubules probes luminal access by soluble proteins
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Protein Sorting in Healthy and Diseased Photoreceptors
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Septin dynamics and organization in mammalian cells
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Reorganization of Septins Modulates Synaptic Transmission at Neuromuscular Junctions
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Immunofluorescent staining of septins in primary cilia
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Self-citationСЕПТИНОВЫЕ КОМПЛЕКСЫ И?ДИНАМИКА ЦИТОСКЕЛЕТА, "Молекулярная биология"
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SEPT9_i1 and Septin Dynamics in Oncogenesis and Cancer Treatment
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Septins: Structural Insights, Functional Dynamics, and Implications in Health and Disease
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Tugging at the Heart Strings: The Septin Cytoskeleton in Heart Development and Disease
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Protein Kinase A-Mediated Septin7 Phosphorylation Disrupts Septin Filaments and Ciliogenesis
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Septin Polymerization Slows Synaptic Vesicle Recycling in Motor Nerve Endings
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Single‐molecule localization microscopy of septin bundles in mammalian cells
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sept7b is required for the differentiation of pancreatic endocrine progenitors
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In situ proteomics unveils specialized domains for extrasynaptic signaling on neuronal cilia
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- Authors
- Ghossoub, R., Hu, Q., Failler, M., Rouyez, M.-C., Spitzbarth, B., Mostowy, S., Wolfrum, U., Saunier, S., Cossart, P., Nelson, W. J., & Benmerah, A.
- Affiliations
- Inserm (FR)
- Stanford University (US)
- Institut Cochin (FR)
- Johannes Gutenberg University Mainz (DE)
- Institut Pasteur (FR)
- Hôpital Necker-Enfants Malades (FR)
- ORCID
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2013-01-01
- Volume
- 126
- Issue
- Pt 12
- Pages
- 2583-94
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- PMC
- PMC3687695
- OpenAlex
- W2115649406
- Cited by
- 128
- References
- 52
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 13 · 2020: 9 · 2019: 9 · 2018: 14 · 2017: 9 · 2016: 13 · 2015: 12 · 2014: 10 · 2013: 9
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Cell Science (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Funders
- Adobe Systems
- Wellcome Trust (WT097411MA)
- National Institute of General Medical Sciences (GM35527, R37GM035527, R01GM035527)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
- Keywords
- septins, SEPT2, SEPT7, SEPT9, MAP4, primary cilia, axoneme, ciliary length, ciliogenesis, retinal pigment epithelial cells, microtubules, protein complex formation, siRNA knockdown
- MeSH terms
- Actins, Cell Line, Cilia, Epithelial Cells, Humans, Microtubule-Associated Proteins, Retina, Cell Cycle Proteins, Axoneme, Septins
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