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Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and recycling

Allaire, Patrick D., Seyed Sadr, Mohamed, Chaineau, Mathilde, Seyed Sadr, Emad, Konefal, Sarah, Fotouhi, Maryam, Maret, Deborah, Ritter, Brigitte, Del Maestro, Rolando F, McPherson, Peter S.·2012·Journal of Cell Science
DOI 10.1242/jcs.112375
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Abstract

Cells inversely adjust the plasma membrane levels of integrins and cadherins during cell migration and cell-cell adhesion but the regulatory mechanisms that coordinate these trafficking events remain unknown. Here, we demonstrate that the small GTPase Rab35 maintains cadherins at the cell surface to promote cell-cell adhesion. Simultaneously, Rab35 supresses the activity of the GTPase Arf6 to down regulate an Arf6-dependent recycling pathway for β1-integrin and EGF receptors, resulting in inhibition of cell migration and attenuation of signaling downstream of these receptors. Importantly, the phenotypes observed following Rab35 knock down are consistent with the epithelial-mesenchymal transition, a feature of invasive cancer cells, and we show that Rab35 expression is suppressed in a subset of cancers characterized by Arf6 hyperactivity. Our data thus identify a key molecular mechanism that efficiently coordinates the inverse intracellular sorting and cell surface levels of cadherin and integrin receptors for cell migration and differentiation.

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  • In the simplified model, co-residence of TBC1D5 and TBC1D13 to a pseudo-helical Retromer coated tubule would ensure that membrane exiting the retrieval sub-domain has RAB7 in an inactive state (lacks late endosomal identity) and is devoid of active RAB35, restricting association of its effector MICAL1 and preventing F-actin disassembly while simultaneously allowing ARF6 activation to aid recycling

    “The most simplified model to describe a highly dynamic and highly complex set of associations, is that the co-residence of TBC1D5 and TBC1D13 to a pseudo-helical Retromer coated tubule would ensure that membrane exiting the retrieval sub-domain has RAB7 in an inactive state”

    From Mapping of endosomal proximity proteomes reveals Retromer as a hub for RAB GTPase regulation (2025) · cites this paper as [125]

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Authors
Allaire, P. D., Seyed Sadr, M., Chaineau, M., Seyed Sadr, E., Konefal, S., Fotouhi, M., Maret, D., Ritter, B., Del Maestro, R. F., & McPherson, P. S.
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2012-01-01
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.112375
Cited by
89
References
3
Language
en

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