The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Regulation of mTORC1 and its impact on gene expression at a glance
Open accessAbstract
The mechanistic (or mammalian) target of rapamycin (mTOR) is a kinase that regulates key cellular functions linked to the promotion of cell growth and metabolism. This kinase, which is part of two protein complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2), has a fundamental role in coordinating anabolic and catabolic processes in response to growth factors and nutrients. Of the two mTOR complexes, mTORC1 is by far the best characterized. When active, mTORC1 triggers cell growth and proliferation by promoting protein synthesis, lipid biogenesis, and metabolism, and by reducing autophagy. The fact that mTORC1 deregulation is associated with several human diseases, such as type 2 diabetes, cancer, obesity and neurodegeneration, highlights its importance in the maintenance of cellular homeostasis. Over the last years, several groups observed that mTORC1 inhibition, in addition to reducing protein synthesis, deeply affects gene transcription. Here, we review the connections between mTORC1 and gene transcription by focusing on its impact in regulating the activation of specific transcription factors including including STAT3, SREBPs, PPARγ, PPARα, HIF1α, YY1–PGC1α and TFEB. We also discuss the importance of these transcription factors in mediating the effects of mTORC1 on various cellular processes in physiological and pathological contexts.
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Citations
Cites
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Self-citationAKT/PKB signaling: navigating downstream
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BackgroundThe Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
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Self-citation
Cited by
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MTOR: a pharmacologic target for autophagy regulation
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Sarcopenia: Aging-Related Loss of Muscle Mass and Function
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Branched-chain amino acids in metabolic signalling and insulin resistance
Lynch, C. J., & Adams, S. H. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.171 · Cited by 1,461
Metadata
- Authors
- Laplante, M., & Sabatini, D. M.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2013-01-01
- Volume
- 126
- Issue
- Pt 8
- Pages
- 1713-9
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2098628437
- Cited by
- 667
- References
- 102
- FWCI
- 26.90
- Type
- journal article
- Language
- en
- Open access
- green
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