The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy
Open accessAbstract
Autocrine VEGF is necessary for endothelial survival, although the cellular mechanisms supporting this function are unknown. Here, we show that – even after full differentiation and maturation – continuous expression of VEGF by endothelial cells is needed to sustain vascular integrity and cellular viability. Depletion of VEGF from the endothelium results in mitochondria fragmentation and suppression of glucose metabolism, leading to increased autophagy that contributes to cell death. Gene-expression profiling showed that endothelial VEGF contributes to the regulation of cell cycle and mitochondrial gene clusters, as well as several – but not all – targets of the transcription factor FOXO1. Indeed, VEGF-deficient endothelium in vitro and in vivo showed increased levels of FOXO1 protein in the nucleus and cytoplasm. Silencing of FOXO1 in VEGF-depleted cells reversed expression profiles of several of the gene clusters that were de-regulated in VEGF knockdown, and rescued both cell death and autophagy phenotypes. Our data suggest that endothelial VEGF maintains vascular homeostasis through regulation of FOXO1 levels, thereby ensuring physiological metabolism and endothelial cell survival.
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Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
Zhao, J., Brault, J. J., Schild, A., Cao, P., Sandri, M., Schiaffino, S., Lecker, S. H., & Goldberg, A. L. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.004 · Cited by 1,489
Bhaskar, P. T., & Hay, N. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.020 · Cited by 798
FOXO3A directs a protective autophagy program in haematopoietic stem cells
Warr, M. R., Binnewies, M., Flach, J., Reynaud, D., Garg, T., Malhotra, R., Debnath, J., & Passegué, E. (2013) · Nature · doi:10.1038/nature11895 · Cited by 625
Cited by
Eelen, G., de Zeeuw, P., Treps, L., Harjes, U., Wong, B. W., & Carmeliet, P. (2018) · Physiological Reviews · doi:10.1152/physrev.00001.2017 · Cited by 572
Gómez-Virgilio, L., Silva-Lucero, M.-D.-C., Flores-Morelos, D.-S., Gallardo-Nieto, J., Lopez-Toledo, G., Abarca-Fernandez, A.-M., Zacapala-Gómez, A.-E., Luna-Muñoz, J., Montiel-Sosa, F., Soto-Rojas, L. O., et al. (2022) · Cells · doi:10.3390/cells11152262 · Cited by 431
Kim, S., Chung, M., Ahn, J., Lee, S., & Jeon, N. L. (2016) · Lab on a Chip · doi:10.1039/c6lc00910g · Cited by 227
Self-citationPPARβ/δ: linking metabolism to regeneration
Magadum, A., & Engel, F. B. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19072013 · Cited by 110
Repair Mechanisms of the Neurovascular Unit after Ischemic Stroke with a Focus on VEGF
Moon, S., Chang, M.-S., Koh, S.-H., & Choi, Y. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168543 · Cited by 104
Metadata
- Authors
- Domigan, C. K., Warren, C. M., Antanesian, V., Happel, K., Ziyad, S., Lee, S., Krall, A., Duan, L., Torres-Collado, A. X., Castellani, L. W., Elashoff, D., Christofk, H. R., van der Bliek, A. M., Potente, M., & Iruela-Arispe, M. L.
- Venue
- Journal of Cell Science
- Publisher
- The Company of Biologists
- Published
- 2015-06-15
- Volume
- 128
- Issue
- 12
- Pages
- 2236-2248
- ISSN
- 0021-9533 (ISSN-L)
- 1477-9137
- OpenAlex
- W2140642422
- Cited by
- 172
- References
- 5
- FWCI
- 6.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Domigan, C. K., Warren, C. M., Antanesian, V., Happel, K., Ziyad, S., Lee, S., Krall, A., Duan, L., Torres-Collado, A. X., Castellani, L. W., Elashoff, D., Christofk, H. R., van der Bliek, A. M., Potente, M., & Iruela-Arispe, M. L. (2015). Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. Journal of Cell Science. https://doi.org/10.1242/jcs.163774
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
