Cited by 244Mitochondrial Function and PathologyAutophagy in Disease and TherapyCell death mechanisms and regulation

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The constriction and scission machineries involved in mitochondrial fission

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Kraus, Felix, Ryan, Michael T.·2017·Journal of Cell Science

DOI 10.1242/jcs.199562

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Abstract

A key event in the evolution of eukaryotic cells was the engulfment of an aerobic bacterium by a larger anaerobic archaebacterium, leading to a close relationship between the host and the newly formed endosymbiont. Mitochondria, originating from this event, have evolved to be the main place of cellular ATP production. Maintaining elements of their independence, mitochondria undergo growth and division in the cell, thereby ensuring that new daughter cells inherit a mitochondrial complement. Mitochondrial division is also important for other processes, including quality control, mitochondrial (mt)DNA inheritance, transport and cell death. However, unlike bacterial fission, which uses a dynamin-related protein to constrict the membrane at its inner face, mitochondria use dynamin and dynamin-related proteins to constrict the outer membrane from the cytosolic face. In this Review, we summarize the role of proteins from the dynamin superfamily in mitochondrial division. This includes recent findings highlighting that dynamin-2 (Dnm2) is involved in mitochondrial scission, which led to the reappraisal of the role of dynamin-related protein 1 (Drp1; also known as Dnm1l) and its outer membrane adaptors as components of the mitochondrial constriction machinery along with ER components and actin.

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Authors: Kraus, F., & Ryan, M. T.
Affiliations: Monash University (AU)
Corresponding author: Kraus, Felix
ORCID: Kraus, Felix
Ryan, Michael T.
Venue: Journal of Cell Science
Publisher: The Company of Biologists
Published: 2017-09-15
Volume: 130
Issue: 18
Pages: 2953-2960
ISSN: 0021-9533 (ISSN-L)
1477-9137
DOI: 10.1242/jcs.199562
OpenAlex: W2747200758
Cited by: 244
References: 95
Citations by year: 2026: 13 · 2025: 14 · 2024: 25 · 2023: 26 · 2022: 32 · 2021: 40 · 2020: 41 · 2019: 33 · 2018: 19 · 2017: 1
FWCI: 2.41
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.biologists.com/user-licence-1-1 (vor, 181 d)
Locations: Journal of Cell Science (publishedVersion)
Monash University Research Portal (Monash University) (publishedVersion, other-oa)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Funders: Australian Research Council (DP160102176)
National Health and Medical Research Council
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: mitochondrial fission, mitochondrial division, dynamin superfamily, dynamin 2, Drp1, mitochondrial outer membrane, mitochondrial inheritance, endosymbiotic origin of mitochondria, actin, endoplasmic reticulum, mitochondrial quality control
MeSH terms: Actins, Animals, Endoplasmic Reticulum, Humans, Lipids, Models, Biological, Mitochondrial Proteins, Mitochondrial Dynamics

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The constriction and scission machineries involved in mitochondrial fission

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