Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
Abstract
Mitochondrial morphology is dynamically controlled by a balance between fusion and fission. The physiological importance of mitochondrial fission in vertebrates is less clearly defined than that of mitochondrial fusion. Here we show that mice lacking the mitochondrial fission GTPase Drp1 have developmental abnormalities, particularly in the forebrain, and die after embryonic day 12.5. Neural cell-specific (NS) Drp1(-/-) mice die shortly after birth as a result of brain hypoplasia with apoptosis. Primary culture of NS-Drp1(-/-) mouse forebrain showed a decreased number of neurites and defective synapse formation, thought to be due to aggregated mitochondria that failed to distribute properly within the cell processes. These defects were reflected by abnormal forebrain development and highlight the importance of Drp1-dependent mitochondrial fission within highly polarized cells such as neurons. Moreover, Drp1(-/-) murine embryonic fibroblasts and embryonic stem cells revealed that Drp1 is required for a normal rate of cytochrome c release and caspase activation during apoptosis, although mitochondrial outer membrane permeabilization, as examined by the release of Smac/Diablo and Tim8a, may occur independently of Drp1 activity.
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Constitutive DRP1 knockout animals are embryonically lethal, demonstrating that the fission machinery is critical for tissue development and function.
“Constitutive DRP1 knockout animals are embryonically lethal, demonstrating that the fission machinery is critical for tissue development and function [208, 209].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [208]
Conditional ablation of DRP1 in the heart, brain, and skeletal muscle causes lethality.
“Consistent with this crucial role, conditional ablation of DRP1 in the heart, brain, and skeletal muscle causes lethality [196, 198–200, 208, 209].”
From The connection between the dynamic remodeling of the mitochondrial network and the regulation of muscle mass (2021) · cites this paper as [208]
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“Drp1 / MEFs (14) were originally a gift from Prof.”
Background
- Authors
- Ishihara, N., Nomura, M., Jofuku, A., Kato, H., Suzuki, S. O., Masuda, K., Otera, H., Nakanishi, Y., Nonaka, I., Goto, Y.-I., Taguchi, N., Morinaga, H., Maeda, M., Takayanagi, R., Yokota, S., & Mihara, K.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Kyushu University (JP)
- National Institute of Neuroscience (JP)
- Research Institute for Microbial Diseases, The University of Osaka (JP)
- Nagasaki International University (JP)
- Corresponding author
- Mihara, Katsuyoshi
- ORCID
- Venue
- Nature Cell Biology
- Published
- 2009-07-05
- Volume
- 11
- Issue
- 8
- Pages
- 958-966
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2094162211
- Cited by
- 1,066
- References
- 55
- Citations by year
- 2026: 36 · 2025: 41 · 2024: 60 · 2023: 67 · 2022: 64 · 2021: 85 · 2020: 76 · 2019: 66 · 2018: 73 · 2017: 72 · 2016: 70 · 2015: 64 · 2014: 67 · 2013: 58 · 2012: 78
- FWCI
- 22.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- Drp1, mitochondrial fission, mitochondrial GTPase, embryonic development, synaptogenesis, neuronal polarity, mitochondrial morphology, mitochondrial fusion, mitochondrial aggregation, apoptosis, cytochrome c release, caspase activation, mitochondrial outer membrane permeabilization, Smac/DIABLO, forebrain development, axonal mitochondria
- MeSH terms
- Animals, Animals, Newborn, Brain, Cell Line, Cells, Cultured, Embryo, Mammalian, Female, Fibroblasts, Immunohistochemistry, Luminescent Proteins, Male, Mice, Inbred C57BL, Microscopy, Electron, Microscopy, Fluorescence, Mitochondria, Neurons, Synapses, Time Factors, Blotting, Western, Mice, Knockout, GTP Phosphohydrolases, Mitochondrial Proteins, Cytochromes c, Embryonic Development, Mice
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