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Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside
Open accessAbstract
The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570 +/- 29 to 401 +/- 59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.
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“Mangiferin is the main effective component of Anemarrhena asphodeloides (109).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [109]
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“Anemarrhena asphodeloides, a plant widely used in traditional Chinese medicine, has been reported to possess antiviral and antibacterial activities (109).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [109]
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Metadata
- Authors
- MIURA, T., ICHIKI, H., IWAMOTO, N., KATO, M., KUBO, M., SASAKI, H., OKADA, M., ISHIDA, T., SEINO, Y., & TANIGAWA, K.
- Affiliations
- Suzuka University of Medical Science (JP)
- Tsumura (Japan) (JP)
- Kyoto University (JP)
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2001
- Volume
- 24
- Issue
- 9
- Pages
- 1009-1011
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2011225986
- Cited by
- 137
- References
- 9
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 13 · 2015: 4 · 2014: 19 · 2013: 4 · 2012: 3
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- Anemarrhena asphodeloides, rhizome, antidiabetic activity, type 2 diabetes, KK-Ay mice, blood glucose, serum insulin, insulin resistance, insulin tolerance test, mangiferin, phytochemical constituents
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Glucose Tolerance Test, Glucosides, Hypoglycemic Agents, Phytotherapy, Plant Extracts, Plants, Medicinal, Tolbutamide, Xanthenes, Xanthones, Mice
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