Cited by 137Natural Antidiabetic Agents StudiesMangiferin and Mango ExtractsPancreatic function and diabetes

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Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside

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MIURA, Toshihiro, ICHIKI, Hiroyuki, IWAMOTO, Naoki, KATO, Motoshi, KUBO, Masayoshi, SASAKI, Hiroshi, OKADA, Minoru, ISHIDA, Torao, SEINO, Yutaka, TANIGAWA, Keiichiro·2001·Biological and Pharmaceutical Bulletin

DOI 10.1248/bpb.24.1009

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Abstract

The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570 +/- 29 to 401 +/- 59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.

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Authors: MIURA, T., ICHIKI, H., IWAMOTO, N., KATO, M., KUBO, M., SASAKI, H., OKADA, M., ISHIDA, T., SEINO, Y., & TANIGAWA, K.
Affiliations: Suzuka University of Medical Science (JP)
Tsumura (Japan) (JP)
Kyoto University (JP)
ORCID: IWAMOTO, Naoki
OKADA, Minoru
ISHIDA, Torao
SEINO, Yutaka
Venue: Biological and Pharmaceutical Bulletin
Publisher: Pharmaceutical Society of Japan
Published: 2001
Volume: 24
Issue: 9
Pages: 1009-1011
ISSN: 0918-6158 (ISSN-L)
1347-5215
DOI: 10.1248/bpb.24.1009
OpenAlex: W2011225986
Cited by: 137
References: 9
Citations by year: 2025: 3 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 13 · 2015: 4 · 2014: 19 · 2013: 4 · 2012: 3
FWCI: 1.62
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Biological and Pharmaceutical Bulletin (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Keywords: Anemarrhena asphodeloides, rhizome, antidiabetic activity, type 2 diabetes, KK-Ay mice, blood glucose, serum insulin, insulin resistance, insulin tolerance test, mangiferin, phytochemical constituents
MeSH terms: Animals, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Glucose Tolerance Test, Glucosides, Hypoglycemic Agents, Phytotherapy, Plant Extracts, Plants, Medicinal, Tolbutamide, Xanthenes, Xanthones, Mice

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Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside

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