The DOI matches its Crossref record; 8 of the 9 references it cites were found in a registry or an index.
Antidiabetic activity of the rhizoma of Anemarrhena asphodeloides and active components, mangiferin and its glucoside
Open accessAbstract
The antidiabetic activity of the rhizoma of Anemarrhena asphodeloides was investigated in KK-Ay mice, an animal model of genetic type 2 diabetes. The water extract of the rhizoma (AA) (90 mg/kg) reduced blood glucose levels from 570 +/- 29 to 401 +/- 59 mg/dl 7 h after oral administration (p<0.05) and also tended to reduce serum insulin levels in KK-Ay mice. AA-treated KK-Ay mice had significantly reduced blood glucose levels in an insulin tolerance test. Based on these results, the antidiabetic mechanism of AA may be due to decreased insulin resistance. In addition, the active components of AA were confirmed to be mangiferin and its glucoside.
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In the citing paper
“Mangiferin is the main effective component of Anemarrhena asphodeloides (109).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [109]
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In the citing paper
“Anemarrhena asphodeloides, a plant widely used in traditional Chinese medicine, has been reported to possess antiviral and antibacterial activities (109).”
From Mangiferin: An effective therapeutic agent against several disorders (Review) (2018) · cites this paper as [109]
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Citations
Cites
Diabetes-Obesity Syndromes in Mice
Coleman, D. L. (1982) · Diabetes · doi:10.2337/diab.31.1.s1 · Cited by 354
Therapeutic effects of dehydroepiandrosterone (DHEA) in diabetic mice.
Coleman, D. L., Leiter, E. H., & Schwizer, R. W. (1982) · Diabetes · doi:10.2337/diab.31.9.830 · Cited by 317
New Antidiabetic Compounds, Mangiferin and Its Glucoside.
Ichiki, H., Miura, T., Kubo, M., Ishihara, E., KOMATSU, Y., Tanigawa, K., & Okada, M. (1998) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.21.1389 · Cited by 158
Self-citationFujita, M., & Inoué, T. (1982) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.30.2342 · Cited by 67
Takahashi, M., Konno, C., & Hikino, H. (1985) · Planta Medica · doi:10.1055/s-2007-969417 · Cited by 62
Preservation of blood samples for glucose analysis by glucose-oxidase
Marks, V., & Lloyd, K. (1963) · Clinica Chimica Acta · doi:10.1016/0009-8981(63)90184-0 · Cited by 40
KIMURA, M., Kimura, I., & Fu-Jun, C. H. E. N. (1996) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.19.926 · Cited by 30
Suzuki, J., & Kimura, M. (1984) · PubMed · Cited by 12
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1 of the 9 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Suzuki J., Kimura M., 1984, Folia Pharmacol. Jpn., 83, 1, 10.1254/fpj.83.1 · DOI
Cited by
Sorted by citations
Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus
Li, W., Zheng, H. C., Bukuru, J., & KIMPE, N. D. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.12.031 · Cited by 970
Effect of mangiferin on hyperglycemia and atherogenicity in streptozotocin diabetic rats
Muruganandan, S., Srinivasan, K., Gupta, S., Gupta, P. K., & Lal, J. (2005) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.12.010 · Cited by 426
Diabetes is an inflammatory disease: evidence from traditional Chinese medicines
Xie, W., & Du, L. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01336.x · Cited by 305
Dar, A., Faizi, S., Naqvi, S., Roome, T., Zikr-ur-Rehman, S., Ali, M., Firdous, S., & Moin, S. T. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.596 · Cited by 289
McKay, D. L., & Blumberg, J. B. (2006) · Phytotherapy Research · doi:10.1002/ptr.1992 · Cited by 207
Metadata
- Authors
- MIURA, T., ICHIKI, H., IWAMOTO, N., KATO, M., KUBO, M., SASAKI, H., OKADA, M., ISHIDA, T., SEINO, Y., & TANIGAWA, K.
- Affiliations
- Suzuka University of Medical Science (JP)
- Tsumura (Japan) (JP)
- Kyoto University (JP)
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2001
- Volume
- 24
- Issue
- 9
- Pages
- 1009-1011
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W2011225986
- Cited by
- 137
- References
- 9
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 5 · 2016: 13 · 2015: 4 · 2014: 19 · 2013: 4 · 2012: 3
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Mangiferin and Mango Extracts
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- Anemarrhena asphodeloides, rhizome, antidiabetic activity, type 2 diabetes, KK-Ay mice, blood glucose, serum insulin, insulin resistance, insulin tolerance test, mangiferin, phytochemical constituents
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Dose-Response Relationship, Drug, Glucose Tolerance Test, Glucosides, Hypoglycemic Agents, Phytotherapy, Plant Extracts, Plants, Medicinal, Tolbutamide, Xanthenes, Xanthones, Mice
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