Studies on the antioxidant activities of Desmodium gangeticum
Open accessAbstract
Desmodium gangeticum is herbal species which is widely used in the indigenous system of medicine and is reported to contain flavone and isoflavanoid glycosides. In view of its wide use and it's chemical composition, this study was aimed at examining the antioxidant activity of the extract of D. gangeticum. The extract was studied for diphenyl picryl hydrazyl (DPPH), nitric oxide, ferryl-bipyridyl and hypochlorous acid scavenging activity along with lipid peroxidation. Nitric oxide was generated using sodium nitroprusside and was studied using Griess reagent. In order to study the iron chelating capacity of the extract, the percentage ferryl-bipyridyl inhibition was studied. Hypochlorous acid scavenging activity was tested by measuring the inhibition of 5-thio-2-nitrobenzoic acid oxidation. The extract was also studied for lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat brain homogenate. The results indicate that D. gangeticum extract has potent antioxidant activity.
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Antioxidant, anti-inflammatory and AChE inhibitory activity of D. gangeticum has been reported.
“Antioxidant, anti-inflammatory and AChE inhibitory activity of D. gangeticum has also been reported [199,201,202].”
From Indian Medicinal Herbs and Formulations for Alzheimer’s Disease, from Traditional Knowledge to Scientific Assessment (2020) · cites this paper as [201]
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- Authors
- Govindarajan, R., Rastogi, S., Vijayakumar, M., Shirwaikar, A., Rawat, A. K. S., Mehrotra, S., & Pushpangadan, P.
- Affiliations
- National Botanical Research Institute (IN)
- Pharmacognosy Department, College of Pharmaceutical Sciences, India
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2003
- Volume
- 26
- Issue
- 10
- Pages
- 1424-1427
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W1997924931
- Cited by
- 327
- References
- 23
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 17 · 2023: 13 · 2022: 17 · 2021: 18 · 2020: 23 · 2019: 15 · 2018: 11 · 2017: 13 · 2016: 10 · 2015: 19 · 2014: 19 · 2013: 21 · 2012: 28
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Biological and Pharmaceutical Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
- Keywords
- Desmodium gangeticum, antioxidant activity, plant extracts, DPPH radical scavenging, nitric oxide scavenging, hypochlorous acid scavenging, lipid peroxidation, iron chelation, flavone glycosides, rat brain homogenate
- MeSH terms
- Animals, Antioxidants, Brain, Fabaceae, Male, Plant Extracts, Free Radical Scavengers, Rats, Sprague-Dawley, Plant Components, Aerial, Rats
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