The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Antimelanogenic and Antioxidant Properties of Gallic Acid
Open accessAbstract
To find novel skin-whitening agents, the melanogenesis inhibitory action of gallic acid (GA) was investigated. In this current study, the effects of GA on mushroom tyrosinase, tyrosinase inhibitory activity, and melanin content were assessed in B16 melanoma cells (B16 cells). Results indicated that GA has a strong antityrosinase activity (IC50=3.59x10(-6) M). Furthermore, data on murine tyrosinase activity and melanin biosynthesis revealed that GA effectively suppressed murine tyrosinase action and the amount of melanin. To investigate the relation between GA's inhibition of melanogenesis and antioxidant activity, the effect of GA on reactive species (RS) generation and the reduced glutathione (GSH)/oxidized glutathione (GSSG) ratio in were determined in B16 cells. Results indicated that GA effectively down-regulated the RS generation and enhanced the GSH/GSSG ratio. Based on these results, I propose that GA exerts antimelanogenic activity coupled with antioxidant properties by suppressing RS generation and maintaining a higher GSH/GSSG ratio.
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Cites
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Cited by
Ruiz, H. A., Rodríguez-Jasso, R. M., Fernandes, B. D., Vicente, A. A., & Teixeira, J. A. (2013) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2012.11.069 · Cited by 608
Oxidative stress in the skin: Impact and related protection
Chen, J., Liu, Y., Zhao, Z., & Qiu, J. (2021) · International Journal of Cosmetic Science · doi:10.1111/ics.12728 · Cited by 351
Su, T.-R., Lin, J.-J., Tsai, C.-C., Huang, T.-K., Yang, Z.-Y., Wu, M.-O., Zheng, Y.-Q., Su, C.-C., & Wu, Y.-J. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms141020443 · Cited by 156
Metadata
- Authors
- Kim, Y.-J.
- Venue
- Biological and Pharmaceutical Bulletin
- Publisher
- Pharmaceutical Society of Japan
- Published
- 2007
- Volume
- 30
- Issue
- 6
- Pages
- 1052-1055
- ISSN
- 0918-6158 (ISSN-L)
- 1347-5215
- OpenAlex
- W1970109190
- Cited by
- 340
- References
- 27
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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