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Detection of acute toxicity of aflatoxin B1 to human hepatocytes in vitro and in vivo using chimeric mice with humanized livers

Ishida, Y., Yamasaki, C., Iwanari, H., Yamashita, H., Ogawa, Y., Yanagi, A., Furukawa, S., Kojima, Y., Chayama, K., Kamiie, J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0239540 · Cited by 23 · see citing works

In vitro cell-based models of drug-induced hepatotoxicity screening: progress and limitation

Mirahmad, M., Sabourian, R., Mahdavi, M. R., Larijani, B. A., & Safavi, M. (2022) · Drug Metabolism Reviews · doi:10.1080/03602532.2022.2064487 · Cited by 20 · see citing works

Optimisation of the HepaRG cell line model for drug toxicity studies using two different cultivation conditions: advantages and limitations

Hammour, M. M., Othman, A., Aspera-Werz, R. H., Braun, B., Weis-Klemm, M., Wagner, S., Nadalin, S., Histing, T., Ruoß, M., & Nussler, A. K. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03329-8 · Cited by 21 · see citing works

Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis

Fernandes, C., Videira, A. J. C., Veloso, C. D., Benfeito, S., Soares, P., Martins, J. D., Gonçalves, B., Duarte, J. F. S., Santos, A. M. S., Oliveira, P. J., et al. (2021) · Biomolecules · doi:10.3390/biom11111605 · Cited by 20 · see citing works

Toward 3D‐Bioprinted Models of the Liver to Boost Drug Development

Guagliano, G., Volpini, C., Vangosa, F. B., Cornaglia, A. I., Visai, L., & Petrini, P. (2022) · Macromolecular Bioscience · doi:10.1002/mabi.202200264 · Cited by 20 · see citing works

Cytotoxicity of new psychoactive substances and other drugs of abuse studied in human HepG2 cells using an adopted high content screening assay

Richter, L. H. J., Beck, A., Flockerzi, V., Maurer, H. H., & Meyer, M. R. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.11.007 · Cited by 20 · see citing works

Monitoring metabolism of synthetic cannabinoid 4F-MDMB-BINACA via high-resolution mass spectrometry assessed in cultured hepatoma cell line, fungus, liver microsomes and confirmed using urine samples

Leong, H. S., Watanabe, S., Kuzhiumparambil, U., Fong, C. Y., Moy, H. Y., Yao, Y. J., Witting, P. K., & Fu, S. (2020) · Forensic Toxicology · doi:10.1007/s11419-020-00562-7 · Cited by 19 · see citing works

Characterization of a commercially available line of iPSC hepatocytes as models of hepatocyte function and toxicity for regulatory purposes

Qosa, H., Ribeiro, A. J. S., Hartman, N. R., & Volpe, D. A. (2021) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2021.107083 · Cited by 19 · see citing works

Evodiamine derivatives improve cognitive abilities in APPswe/PS1ΔE9 transgenic mouse models of Alzheimer's disease

Pang, S., Sun, C., Gao, S., Yang, Y., Pan, X., & Zhang, L. (2020) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12126 · Cited by 18 · see citing works

Emerging Three-Dimensional Hepatic Models in Relation to Traditional Two-Dimensional In Vitro Assays for Evaluating Drug Metabolism and Hepatoxicity

Milner, E., Ainsworth, M., McDonough, M., Stevens, B. D., Buehrer, J., Delzell, R., Wilson, C., & Barnhill, J. C. (2020) · Medicine in Drug Discovery · doi:10.1016/j.medidd.2020.100060 · Cited by 19 · see citing works

Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System

Negoro, R., Tasaka, M., Deguchi, S., Takayama, K., & Fujita, T. (2022) · Cells · doi:10.3390/cells11101677 · Cited by 16 · see citing works

Effects of vanadium (sodium metavanadate) and aflatoxin-B1 on cytochrome p450 activities, DNA damage and DNA methylation in human liver cell lines

Desaulniers, D. M., Cummings‐Lorbetskie, C., Leingartner, K., Xiao, G. ‐., Zhou, G., & Parfett, C. L. J. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.105036 · Cited by 16 · see citing works

Natural-Product-Inspired Compounds as Countermeasures against the Liver Carcinogen Aflatoxin B1

Carter, A. C., King, J. B., Mattes, A. O., Cai, S., Singh, N. P., & Cichewicz, R. H. (2019) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b00290 · Cited by 16 · see citing works

Analysis of Live Single Cells by Confocal Microscopy and High-Resolution Mass Spectrometry to Study Drug Uptake, Metabolism, and Drug-Induced Phospholipidosis

Pedro, L., & Rudewicz, P. J. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.0c03534 · Cited by 16 · see citing works

Pesticide mixture effects on liver protein abundance in HepaRG cells

Schmidt, F. F., Lichtenstein, D., Planatscher, H., Mentz, A., Kalinowski, J., Steinhilber, A., Joos, T. O., Braeuning, A., & Pötz, O. (2021) · Toxicology · doi:10.1016/j.tox.2021.152839 · Cited by 15 · see citing works

Analyzing the metabolic fate of oral administration drugs: A review and state-of-the-art roadmap

Liu, L., Liu, Y., Zhou, X., Xu, Z., Zhang, Y., Ji, L., Hong, C., & Li, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.962718 · Cited by 16 · see citing works

Time-course characterization of whole-transcriptome dynamics of HepG2/C3A spheroids and its toxicological implications

Kim, C., Zhu, Z., Barbazuk, W. B., Bacher, R. L., & Vulpe, C. D. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.10.004 · Cited by 16 · see citing works

Assessment of α-amanitin toxicity and effects of silibinin and penicillin in different in vitro models

Popp, T., Balszuweit, F., Schmidt, A., Eyer, F., Thiermann, H., & Steinritz, D. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104921 · Cited by 15 · see citing works

Physiologically relevant oxygen tensions differentially regulate hepatotoxic responses in HepG2 cells

DiProspero, T. J., Dalrymple, E., & Lockett, M. R. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105156 · Cited by 14 · see citing works

Validating Well-Functioning Hepatic Organoids for Toxicity Evaluation

Choi, S. Y., Kim, T. H., Kim, M. J., Mun, S. J., Kim, T., Jung, K. K., Oh, I. U., Oh, J. H., Son, M. J., & Lee, J. H. (2024) · Toxics · doi:10.3390/toxics12050371 · Cited by 14 · see citing works

When less is more: The association between the expression of polymorphic CYPs and AFB1 ‐induced HCC

Mohamed, A. A., Armanious, M., Bedair, R. W., Amin, N. S., & Tayebi, H. M. E. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14297 · Cited by 13 · see citing works

Administration of Secretome Derived from Human Mesenchymal Stem Cells Induces Hepatoprotective Effects in Models of Idiosyncratic Drug-Induced Liver Injury Caused by Amiodarone or Tamoxifen

Huang, Y.-L., Gregorio, C. D., Silva, V., Elorza, Á. A., Léniz, P., Aliaga-Tobar, V., Maracaja‐Coutinho, V., Budini, M., Ezquer, F. E., & Ezquer, M. (2023) · Cells · doi:10.3390/cells12040636 · Cited by 13 · see citing works

Detoxification of comfrey (Symphytum officinale L.) extract using natural deep eutectic solvent (NADES) and evaluation of its anti-inflammatory, antioxidant, and hepatoprotective properties

Syarifah, A. N., Suryadi, H., Hayun, H., Simamora, A., & Mun’im, A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1012716 · Cited by 15 · see citing works

Comparative proteomic analysis of SLC13A5 knockdown reveals elevated ketogenesis and enhanced cellular toxic response to chemotherapeutic agents in HepG2 cells

Hu, T., Huang, W., Li, Z., Kane, M. A., Zhang, L., Huang, S. M., & Wang, H. (2020) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2020.115117 · Cited by 12 · see citing works

Imbalance in the antioxidant defence system and pro-genotoxic status induced by high glucose concentrations: In vitro testing in human liver cells

Acito, M., Bartolini, D., Ceccarini, M. R., Russo, C. A., Vannini, S., Dominici, L., Codini, M., Villarini, M., Galli, F., Beccari, T., et al. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.105001 · Cited by 12 · see citing works

A Review on New Frontiers in Drug-Drug Interaction Predictions and Safety Evaluations with In Vitro Cellular Models

Marques, L., & Vale, N. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17060747 · Cited by 12 · see citing works

Effects of di-(2-ethylhexyl) phthalate and its metabolites on transcriptional activity via human nuclear receptors and gene expression in HepaRG cells

Yasuda, A., Murase, W., Kubota, A., Uramaru, N., Okuda, K., Hakota, R., Ikeda, A., & Kojima, H. (2024) · Toxicology in Vitro · doi:10.1016/j.tiv.2024.105943 · Cited by 11 · see citing works

Cell-based high-throughput screening for the evaluation of reactive metabolite formation potential

Harada, K., Kohara, H., Yukawa, T., Matsumiya, K., & Shinozawa, T. (2021) · Toxicology in Vitro · doi:10.1016/j.tiv.2021.105159 · Cited by 11 · see citing works

Manganese-oxidizing bacteria form multiple cylindrospermopsin transformation products with reduced human liver cell toxicity

Martínez-Ruiz, E. B., Cooper, M., Al‐Zeer, M. A., Kurreck, J., Adrian, L., & Szewzyk, U. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.138924 · Cited by 11 · see citing works

Effects of aflatoxin B1 on subacute exposure of hybrid groupers (Epinephelus fuscoguttatus♀ × Epinephelus lanceolatus♂): Growth, liver histology, and integrated liver transcriptome and metabolome analysis

Liu, H., Liang, S., Huang, W., Yang, Y., Zhou, M., Lu, B., Li, B., Cai, W., Song, H., Tan, B., et al. (2024) · Animal nutrition · doi:10.1016/j.aninu.2024.08.002 · Cited by 10 · see citing works

Identification of p53 Activators in a Human Microarray Compendium

Corton, J. C., Witt, K. L., & Yauk, C. L. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.9b00052 · Cited by 10 · see citing works

Exploring the biological impact of bacteria-derived indole compounds on human cell health: Cytotoxicity and cell proliferation across six cell lines

Janiga-MacNelly, A., Vrazel, M., Roat, A. E., Fernández-Luna, M. T., & Lavado, R. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101883 · Cited by 9 · see citing works

Novel emerging cell and organoid systems for the study of drug metabolism and toxicity in humans

Gracey, E. G., & Lampe, J. N. (2025) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2025.100188 · Cited by 10 · see citing works

Cytotoxicity, metabolism, and isozyme mapping of the synthetic cannabinoids JWH-200, A-796260, and 5F-EMB-PINACA studied by means of in vitro systems

Gampfer, T. M., Wagmann, L., Belkacemi, A., Flockerzi, V., & Meyer, M. R. (2021) · Archives of Toxicology · doi:10.1007/s00204-021-03148-3 · Cited by 9 · see citing works

Isoflucypram: Combining in vivo and NAMs data in a weight of evidence approach to demonstrate the human non-relevance of the mode of action leading to the subtle thyroid effects observed in the rat

Tinwell, H., & Bars, R. (2022) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2022.105154 · Cited by 9 · see citing works

HepaRG Cells Adopt Zonal-Like Drug-Metabolizing Phenotypes under Physiologically Relevant Oxygen Tensions and Wnt/β-Catenin Signaling

DiProspero, T. J., Brown, L. G., Fachko, T. D., & Lockett, M. R. (2022) · Drug Metabolism and Disposition · doi:10.1124/dmd.122.000870 · Cited by 8 · see citing works

Ashwagandha ( Withania somnifera ) Plant Extracts Affect the Cytochrome P450 System and Cytotoxicity of Primary Human Hepatocytes

McDonald, K. L., Raichura, Z., Pondugula, S. R., Marney, L. C., Yang, L., Choi, J., Salamat, J. M., Brandes, M. S., Neff, C. J., Adams, K., et al. (2025) · Journal of Dietary Supplements · doi:10.1080/19390211.2025.2514458 · Cited by 8 · see citing works

Computational approaches to DMPK: A realistic assessment of current methods and their practical impact. Part I: Physicochemical and in vitro properties

D, K. H. M., Hirano, M., Kageyama, M., & Bender, A. (2025) · Drug Discovery Today · doi:10.1016/j.drudis.2025.104422 · Cited by 8 · see citing works

Liver Extracellular Matrix-Based Nanofiber Scaffolds for the Culture of Primary Hepatocytes and Drug Screening

Vasudevan, A., Majumder, N., Sharma, I., Kaur, I., Sundarrajan, S., Venugopal, J. R., Vijayaraghavan, P., Singh, N., Ramakrishna, S., Ghosh, S., et al. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c01216 · Cited by 8 · see citing works

Human HepaRG liver spheroids: cold storage protocol and study on pyridinium oxime-induced hepatotoxicity in vitro

Horn, G., Kranawetvogl, T., John, H., Weigel, C., Rauen, U., Worek, F., & Wille, T. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110285 · Cited by 8 · see citing works

Mitochondrial Lipid Peroxidation and Microsomal Drug-metabolizing Enzyme Activity of Rat Hepatotoxicity under Heavy Metals from Slag Waste Exposure

Mu, H., Wan, W., Song, J., Kuang, R., & Deng, T. (2023) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-023-01134-3 · Cited by 8 · see citing works

Development of a human liver microphysiological coculture system for higher throughput chemical safety assessment

Ip, B. C., Madnick, S. J., Zheng, S., van Tongeren, T. C. A., Hall, S. J., Li, H., Martin, S., Spriggs, S., Carmichael, P. L., Chen, W., et al. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae018 · Cited by 8 · see citing works

In vitro liver models for toxicological research

Fukunaga, I., & Takebe, T. (2025) · Drug Metabolism and Pharmacokinetics · doi:10.1016/j.dmpk.2025.101478 · Cited by 7 · see citing works

Advanced 3D In Vitro Liver Fibrosis Models: Spheroids, Organoids, and Liver-on-Chips

Lee, J. E., Lee, Y., & Yoon, J. (2025) · Biomimetics · doi:10.3390/biomimetics10100639 · Cited by 8 · see citing works

Dehydrometabolites of siphonaxanthin, a carotenoid from green algae, suppress toll-like receptor 1/2-induced inflammatory response more strongly than siphonaxanthin

Manabe, Y., Nitta, T., Ichihara, M., Maoka, T., & Sugawara, T. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108246 · Cited by 7 · see citing works

Human-Induced Pluripotent Stem Cell-Derived Hepatocytes and their Culturing Methods to Maintain Liver Functions for Pharmacokinetics and Safety Evaluation of Pharmaceuticals

Inoue, T., Iwazaki, N., Araki, T., & Hitotsumachi, H. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200131123524 · Cited by 7 · see citing works

Rapid Detection of Direct Compound Toxicity and Trailing Detection of Indirect Cell Metabolite Toxicity in a 96-Well Fluidic Culture Device for Cell-Based Screening Environments: Tactics in Six Sigma Quality Control Charts

Lubamba, B., Jensen, T. C., & McClelland, R. (2022) · Applied Sciences · doi:10.3390/app12062786 · Cited by 7 · see citing works

Molecular Profiling of Human Induced Pluripotent Stem Cell-Derived Cells and their Application for Drug Safety Study

Matsui, T., Miyamoto, N., Saito, F., & Shinozawa, T. (2020) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201021666200422090952 · Cited by 7 · see citing works

Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells

Tang, L. W. T., Lim, R. Y. R., Venkatesan, G., & Chan, E. C. Y. (2022) · Toxicology Research · doi:10.1093/toxres/tfac017 · Cited by 7 · see citing works

Adverse outcome pathway-based analysis of liver steatosis in vitro using human liver cell lines

Karaca, M., Fritsche, K., Lichtenstein, D., Vural, Ö., Kreuzer, K., Alarcan, J., Braeuning, A., Marx‐Stoelting, P., & Tralau, T. (2023) · STAR Protocols · doi:10.1016/j.xpro.2023.102500 · Cited by 6 · see citing works

Effects of Mixtures of Emerging Pollutants and Drugs on Modulation of Biomarkers Related to Toxicity, Oxidative Stress, and Cancer

Manuguerra, S., Carli, F., Scoditti, E., Santulli, A., Gastaldelli, A., & Messina, C. M. (2024) · Metabolites · doi:10.3390/metabo14100559 · Cited by 6 · see citing works

Metabolic Stability of New Mito-Protective Short-Chain Naphthoquinones

Feng, Z., Smith, J. A., Gueven, N., & Quirino, J. P. (2020) · Pharmaceuticals · doi:10.3390/ph13020029 · Cited by 6 · see citing works

P450s under Restriction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals

Hartman, G. D., Kuduk, S. D., Espiritu, C., & Lam, A. M. I. (2020) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.9b00630 · Cited by 6 · see citing works

Genotoxicity testing of the anthraquinone dye Alizarin Red S

Bauer, B., Rossi, H., & Hintzsche, H. (2024) · Current Research in Toxicology · doi:10.1016/j.crtox.2024.100208 · Cited by 5 · see citing works

Toxicity evaluation of Camellia sinensis var. assamica and its fermented miang product

Ounjaijean, S., Chachiyo, S., Kulprachakarn, K., Saenjum, C., Rerkasem, K., Srichairatakool, S., Boonyapranai, K., Parklak, W., & Somsak, V. (2020) · Pharmacognosy Research · doi:10.4103/pr.pr_22_20 · Cited by 5 · see citing works

The human hepatoma HepaRG cells: A highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

Guillouzo, A., Corlu, A., Aninat, C., Glaise, D., Morel, F., & Guguen‐Guillouzo, C. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2006.12.003 · Cited by 675 · see citing works

The HepaRG cell line: a unique in vitro tool for understanding drug metabolism and toxicology in human

Andersson, T. B., Kanebratt, K. P., & Kenna, J. G. (2012) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2012.685159 · Cited by 260 · see citing works

Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies

Jossé, R., Aninat, C., Glaise, D., Dumont, J., Fessard, V., Morel, F., Poul, J., Guguen‐Guillouzo, C., & Guillouzo, A. (2008) · Drug Metabolism and Disposition · doi:10.1124/dmd.107.019901 · Cited by 187 · see citing works

Optimisation of the HepaRG cell line model for drug toxicity studies using two different cultivation conditions: advantages and limitations

Hammour, M. M., Othman, A., Aspera-Werz, R. H., Braun, B., Weis-Klemm, M., Wagner, S., Nadalin, S., Histing, T., Ruoß, M., & Nussler, A. K. (2022) · Archives of Toxicology · doi:10.1007/s00204-022-03329-8 · Cited by 21 · see citing works

Optimization of the HepaRG cell model for drug metabolism and toxicity studies

Anthérieu, S., Chesné, C., Li, R., Guguen‐Guillouzo, C., & Guillouzo, A. (2012) · Toxicology in Vitro · doi:10.1016/j.tiv.2012.05.008 · Cited by 177 · see citing works