A lung/liver-on-a-chip platform for acute and chronic toxicity studies
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A lung/liver-on-a-chip platform with metabolic capability over 28 days: a fit-for-purpose microfluidic system for toxicity assessment of pulmonary toxicants.
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The liver/lung-on-a-chip platform can evaluate the toxicity of AFB1 to liver-lung crosstalk.
“Through this platform, the toxicity of AFB1 to liver–lung crosstalk could be evaluated.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [79]
Liver detoxification can reduce AFB1 toxicity.
“Researchers have found that when liver spheroids are present, AFB1 toxicity in the lung-on-a-chip is reduced, demonstrating that liver detoxification can reduce AFB1 toxicity.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [79]
The liver/lung-on-a-chip platform can evaluate cell viability by observing ATP content and the number of apoptotic necrotic cells.
“This platform can evaluate cell viability by observing the content of adenosine triphosphate (ATP) and the number of apoptotic necrotic cells.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [79]
When liver spheroids are present, AFB1 toxicity in the lung-on-a-chip is reduced.
“Researchers have found that when liver spheroids are present, AFB1 toxicity in the lung-on-a-chip is reduced, demonstrating that liver detoxification can reduce AFB1 toxicity.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [79]
The lung-on-a-chip model can simulate multiple physiological functions of the lung.
“This model can simulate multiple physiological functions of the lung.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [79]
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- Authors
- Bovard, D., Sandoz, A., Luettich, K., Frentzel, S., Iskandar, A., Marescotti, D., Trivedi, K., Guedj, E., Dutertre, Q., Peitsch, M. C., & Hoeng, J.
- Affiliations
- Philip Morris International (Switzerland) (CH)
- Corresponding author
- Bovard, David
- ORCID
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 18
- Issue
- 24
- Pages
- 3814-3829
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2901176860
- Cited by
- 195
- References
- 79
- Citations by year
- 2026: 20 · 2025: 25 · 2024: 23 · 2023: 27 · 2022: 29 · 2021: 29 · 2020: 27 · 2019: 15
- FWCI
- 7.10
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Lab on a Chip (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- multi-organ-on-a-chip, air-liquid interface, cytochrome P450 induction, aflatoxin B1, detoxification, aerosol toxicity, chronic obstructive pulmonary disease, lung cancer, drug safety assessment
- MeSH terms
- Cells, Cultured, Equipment Design, Humans, Liver, Lung, Models, Biological, Aflatoxin B1, Toxicity Tests, Spheroids, Cellular, Coculture Techniques, Inhalation Exposure, Tissue Array Analysis
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