Cited by 1953D Printing in Biomedical ResearchDrug-Induced Hepatotoxicity and ProtectionTissue Engineering and Regenerative Medicine

A lung/liver-on-a-chip platform for acute and chronic toxicity studies

Open access
Bovard, David, Sandoz, Antonin, Luettich, Karsta, Frentzel, Stefan, Iskandar, Anita, Marescotti, Diego, Trivedi, Keyur, Guedj, Emmanuel +3 more·2018·Lab on a Chip

Abstract

A lung/liver-on-a-chip platform with metabolic capability over 28 days: a fit-for-purpose microfluidic system for toxicity assessment of pulmonary toxicants.

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Integrity signals

Registry

Crossref · 10.1039/c8lc01029c

Cites

79 of 79 references verified0 citation errors · 0 not checkable

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  • The liver/lung-on-a-chip platform can evaluate the toxicity of AFB1 to liver-lung crosstalk.

    “Through this platform, the toxicity of AFB1 to liver–lung crosstalk could be evaluated.”
  • Liver detoxification can reduce AFB1 toxicity.

    “Researchers have found that when liver spheroids are present, AFB1 toxicity in the lung-on-a-chip is reduced, demonstrating that liver detoxification can reduce AFB1 toxicity.”
  • The liver/lung-on-a-chip platform can evaluate cell viability by observing ATP content and the number of apoptotic necrotic cells.

    “This platform can evaluate cell viability by observing the content of adenosine triphosphate (ATP) and the number of apoptotic necrotic cells.”
  • When liver spheroids are present, AFB1 toxicity in the lung-on-a-chip is reduced.

    “Researchers have found that when liver spheroids are present, AFB1 toxicity in the lung-on-a-chip is reduced, demonstrating that liver detoxification can reduce AFB1 toxicity.”
  • The lung-on-a-chip model can simulate multiple physiological functions of the lung.

    “This model can simulate multiple physiological functions of the lung.”

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Cites

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Research works printed but not linked: 1

  1. F. K.-M. Chan, K. Moriwaki and M. J. De Rosa, Detection of Necrosis by Release of Lactate Dehydrogenase Activity, in Immune Homeostasis, ed. A. L. Snow and M. J. Lenardo, Humana Press, Totowa, NJ, 2013, pp. 65-70.

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Authors
Bovard, D., Sandoz, A., Luettich, K., Frentzel, S., Iskandar, A., Marescotti, D., Trivedi, K., Guedj, E., Dutertre, Q., Peitsch, M. C., & Hoeng, J.
Affiliations
Philip Morris International (Switzerland) (CH)
Corresponding author
Bovard, David
Venue
Lab on a Chip
Published
2018
Volume
18
Issue
24
Pages
3814-3829
ISSN
  • 1473-0189 (ISSN-L)
  • 1473-0197
OpenAlex
W2901176860
Cited by
195
References
79
Citations by year
2026: 20 · 2025: 25 · 2024: 23 · 2023: 27 · 2022: 29 · 2021: 29 · 2020: 27 · 2019: 15
FWCI
7.10
Type
journal article
Language
en
Open access
Locations
  • Lab on a Chip (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Keywords
multi-organ-on-a-chip, air-liquid interface, cytochrome P450 induction, aflatoxin B1, detoxification, aerosol toxicity, chronic obstructive pulmonary disease, lung cancer, drug safety assessment
MeSH terms
Cells, Cultured, Equipment Design, Humans, Liver, Lung, Models, Biological, Aflatoxin B1, Toxicity Tests, Spheroids, Cellular, Coculture Techniques, Inhalation Exposure, Tissue Array Analysis

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