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Cited by 469

The DOI matches its Crossref record.

Acute inflammation: the underlying mechanism in delayed onset muscle soreness?

SMITH, LUCILLE L.·1991·Medicine and Science in Sports and Exercise
DOI 10.1249/00005768-199105000-00006
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Abstract

It is well documented in animal and human research that unaccustomed eccentric muscle action of sufficient intensity and/or duration causes disruption of connective and/or contractile tissue. In humans, this appears to be associated with the sensation of delayed onset muscle soreness (DOMS). During the late 1970's, it was proposed that this sensation of soreness might be associated with the acute inflammatory response. However, subsequent research failed to substantiate this theory. The present article suggests that the results of much of the research concerning DOMS reflect events typically seen in acute inflammation. Similarities between the two events include: the cardinal symptoms of pain, swelling, and loss of function; evidence of cellular infiltrates, especially the macrophage; biochemical markers such as increased lysosomal activity and increased circulating levels of some of the acute phase proteins; and histological changes during the initial 72 h. In the final section of this paper, a theoretical sequence of events is proposed, based on research involving acute inflammation and DOMS.

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Metadata

Authors
SMITH, L. L.
Venue
Medicine and Science in Sports and Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1991-05
Volume
23
Issue
5
Pages
542???551
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/00005768-199105000-00006
OpenAlex
W1969683573
Cited by
469
References
0
FWCI
9.52
Type
journal article
Language
en
Open access
closed

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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