Ibuprofen and Acetaminophen: Effect on Muscle Inflammation after Eccentric Exercise
Abstract
PETERSON, J. M., T. A. TRAPPE, E. MYLONA, F. WHITE, C. P. LAMBERT, W. J. EVANS, and F. X. PIZZA. Ibuprofen and Acetaminophen: Effect on Muscle Inflammation after Eccentric Exercise. Med. Sci. Sports Exerc., Vol. 35, No. 6, pp. 892–896, 2003. Purpose We examined the influence of ibuprofen and acetaminophen on muscle neutrophil and macrophage concentrations after novel eccentric contractions. Methods Twenty-four males (25 ± 3 yr) were divided into three groups that received the maximal over-the-counter dose of either ibuprofen (1200 mg·d−1), acetaminophen (4000 mg·d−1), or a placebo after eccentric contractions of the knee extensors. Biopsies from the vastus lateralis were taken before and 24 h after exercise. Inflammatory cells were quantified in muscle cross-sections using immunohistochemistry. Results Macrophage concentrations were elevated by 1.5- to 2.5-fold (P < 0.05) at 24 h postexercise relative to preexercise concentrations, whereas neutrophil concentrations were not significantly elevated. Muscle inflammatory cell concentrations were unaffected by treatment with ibuprofen or acetaminophen when compared with placebo. Conclusions Maximal over-the-counter doses of ibuprofen or acetaminophen, when administered therapeutically, do not affect muscle concentrations of neutrophils or macrophages 24 h after a novel bout of eccentric contractions.
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A number of studies have found no effect of NSAIDs on analgesia or inflammation during exercise.
“By contrast, a number of studies have found no effect of NSAIDs on analgesia or inflammation during exercise [184–188].”
From International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing (2019) · cites this paper as [188]
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- Authors
- PETERSON, J. M., TRAPPE, T. A., MYLONA, E., WHITE, F., LAMBERT, C. P., EVANS, W. J., & PIZZA, F. X.
- Affiliations
- University of Toledo (US)
- University of Arkansas for Medical Sciences (US)
- ORCID
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2003-06
- Volume
- 35
- Issue
- 6
- Pages
- 892-896
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2111316642
- Cited by
- 85
- References
- 28
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 2 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG-00831)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- ibuprofen, paracetamol, muscle inflammation, eccentric exercise, macrophages, neutrophils, vastus lateralis, knee extensors, nonsteroidal anti-inflammatory drugs, over-the-counter analgesics
- MeSH terms
- Acetaminophen, Administration, Oral, Adult, Anti-Inflammatory Agents, Non-Steroidal, Double-Blind Method, Female, Humans, Ibuprofen, Inflammation, Macrophages, Male, Neutrophils, Exercise, Muscle, Skeletal, Analgesics, Non-Narcotic
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