Cited by 56Exercise and Physiological ResponsesMuscle Physiology and DisordersMuscle metabolism and nutrition

Age-associated inflammation and implications for skeletal muscle responses to exercise

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Kunz, Hawley E., Lanza, Ian R.·2023·Experimental Gerontology

Abstract

Aging is associated with profound alterations in skeletal muscle, including loss of muscle mass and function, local inflammation, altered mitochondrial physiology, and attenuated anabolic responses to exercise termed anabolic resistance. "Inflammaging," the chronic, low-grade inflammation associated with aging, may contribute to many of the age-related derangements in skeletal muscle, including its ability to respond to exercise and nutritional stimuli. Inflammation and exercise are closely intertwined in numerous ways. A single bout of muscle-damaging exercise stimulates an acute inflammatory response in the skeletal muscle that is essential for muscle repair and regeneration; however, the chronic systemic and local inflammation associated with aging may impair acute inflammatory and anabolic responses to exercise. In contrast, exercise training is anti-inflammatory, targeting many of the potential root causes of inflammaging. In this review, we discuss the interplay between inflammation and exercise in aging and highlight potential therapeutic targets for improving adaptive responses to exercise in older adults.

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Crossref · 10.1016/j.exger.2023.112177

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  • Bulk tissue homogenization blends transcriptomic profiles of multinucleated myofibers with RNA from resident non-muscle cells, including fibroblasts, endothelial cells, infiltrating immune cells, and uncommitted satellite cells.

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Authors
Kunz, H. E., & Lanza, I. R.
Affiliations
Mayo Clinic (US)
Corresponding author
Lanza, Ian R.
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2023-06
Volume
177
Pages
112177
ISSN
0531-5565 (ISSN-L)
OpenAlex
W4366742334
Cited by
56
References
169
Citations by year
2026: 18 · 2025: 22 · 2024: 14 · 2023: 2
FWCI
1.90
Type
journal article
Language
en
Open access
Locations
  • Experimental Gerontology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Keywords
inflammaging, skeletal muscle aging, exercise training, muscle inflammation, anabolic resistance, muscle atrophy, mitochondrial dysfunction, acute inflammatory response, muscle regeneration, older adults, therapeutic target
MeSH terms
Aged, Aging, Anti-Inflammatory Agents, Humans, Inflammation, Exercise, Muscle, Skeletal

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