Age-associated inflammation and implications for skeletal muscle responses to exercise
Open accessAbstract
Aging is associated with profound alterations in skeletal muscle, including loss of muscle mass and function, local inflammation, altered mitochondrial physiology, and attenuated anabolic responses to exercise termed anabolic resistance. "Inflammaging," the chronic, low-grade inflammation associated with aging, may contribute to many of the age-related derangements in skeletal muscle, including its ability to respond to exercise and nutritional stimuli. Inflammation and exercise are closely intertwined in numerous ways. A single bout of muscle-damaging exercise stimulates an acute inflammatory response in the skeletal muscle that is essential for muscle repair and regeneration; however, the chronic systemic and local inflammation associated with aging may impair acute inflammatory and anabolic responses to exercise. In contrast, exercise training is anti-inflammatory, targeting many of the potential root causes of inflammaging. In this review, we discuss the interplay between inflammation and exercise in aging and highlight potential therapeutic targets for improving adaptive responses to exercise in older adults.
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“This cellular infiltration confounder can lead to systemic false-positive interpretations of muscle-specific translational capacity expansion, effectively obscuring the true magnitude of the nucleolar output driving myofibrillar hypertrophy [72,73].”
From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [72]
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From Ribosome Biogenesis as a Putative Bottleneck to Skeletal Muscle Hypertrophy: Mechanisms, Human Evidence, and Practical Modulators (2026) · cites this paper as [72]
Cites
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works
A role for mitochondria in nlrp3 inflammasome activation
Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works
Schroder, K., & Tschopp, J. (2010) · Cell · doi:10.1016/j.cell.2010.01.040 · Cited by 5,475 · see citing works
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afz046 · Cited by 3,803 · see citing works
Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty
Ferrucci, L., & Fabbri, E. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0064-2 · Cited by 3,690 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1× · see citing works
“Identified by increased expression of the cyclin-dependent kinase inhibitor p16INK4A and lysosome β-galactosidase activity, senescent cells acquire a senescence-associated secretory phenotype (SASP) and secrete proinflammatory cytokines and growth factors (Baker et al., 2011) that likely contribute to the whole body i…”
BackgroundGeroscience: Linking Aging to Chronic Disease
Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Vandanmagsar, B., Youm, Y.-H., Ravussin, A., Galgani, J. E., Stadler, K., Mynatt, R. L., Ravussin, E., Stephens, J. M., & Dixit, V. D. (2011) · Nature Medicine · doi:10.1038/nm.2279 · Cited by 2,655 · see citing works
n−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525 · see citing works
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470 · see citing works
Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428 · see citing works
Senolytics improve physical function and increase lifespan in old age
Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0092-9 · Cited by 2,287 · see citing works
Arnold, L., Henry, A., Poron, F., Baba-Amer, Y., van Rooijen, N., Plonquet, A., Gherardi, R. K., & Chazaud, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070075 · Cited by 2,002 · see citing works
Inflammatory networks during cellular senescence: causes and consequences.
Freund, A., Orjalo, A. V., Desprez, P.-Y., & Campisi, J. (2010) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2010.03.003 · Cited by 1,354 · see citing works
Decline in skeletal muscle mitochondrial function with aging in humans
Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333 · see citing works
Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294 · see citing works
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282 · see citing works
A Special Population of Regulatory T Cells Potentiates Muscle Repair
Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234 · see citing works
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
Cuthbertson, D., Smith, K., Babraj, J., Leese, G., Waddell, T., Atherton, P., Wackerhage, H., Taylor, P. M., & Rennie, M. J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2640fje · Cited by 1,211 · see citing works
Inflammation and frailty in the elderly: A systematic review and meta-analysis
Soysal, P., Stubbs, B., Lucato, P., Luchini, C., Solmi, M., Peluso, R., Sergi, G., Isik, A. T., Manzato, E., Maggi, S., et al. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.08.006 · Cited by 1,089 · see citing works
Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences
Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.020 · Cited by 1,065 · see citing works
Franceschi, C., Garagnani, P., Vitale, G., Capri, M., & Salvioli, S. (2017) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2016.09.005 · Cited by 997 · see citing works
Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study
Cesari, M., Penninx, B. W. J. H., Pahor, M., Lauretani, F., Corsi, A. M., Williams, G. R., Guralnik, J. M., & Ferrucci, L. (2004) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/59.3.m242 · Cited by 901 · see citing works
Interleukin-6 Is an Essential Regulator of Satellite Cell-Mediated Skeletal Muscle Hypertrophy
Serrano, A. L., Baeza-Raja, B., Perdiguero, E., Jardí, M., & Muñoz-Cánoves, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.011 · Cited by 873 · see citing works
Reid, K. F., & Fielding, R. A. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31823b5f13 · Cited by 858 · see citing works
Muscle damage and inflammation during recovery from exercise
Peake, J. M., Neubauer, O., Gatta, P. A. D., & Nosaka, K. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00971.2016 · Cited by 829 · see citing works
Serum IL‐6 Level and the Development of Disability in Older Persons
Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M., Cohen, H. J., Penninx, B., Pahor, M., Wallace, R., & Havlik, R. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01583.x · Cited by 809 · see citing works
Effects of Resistance Training on Older Adults
Hunter, G. R., McCarthy, J. P., & Bamman, M. M. (2004) · Sports Medicine · doi:10.2165/00007256-200434050-00005 · Cited by 764 · see citing works
Kumar, V., Selby, A., Rankin, D., Patel, R., Atherton, P., Hildebrandt, W., Williams, J., Smith, K., Seynnes, O., Hiscock, N., et al. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2008.164483 · Cited by 740 · see citing works
Regulation of Muscle Growth and Regeneration by the Immune System
Tidball, J. G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.150 · Cited by 740 · see citing works
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., Harris, T. B., Kritchevsky, S. B., Newman, A. B., Colbert, L. H., Pahor, M., Rubin, S. M., Tylavsky, F. A., et al. (2009) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp097 · Cited by 683 · see citing works
The Role of Inflammation in Age-Related Sarcopenia
Dalle, S., Rossmeislova, L., & Koppo, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01045 · Cited by 668 · see citing works
Smith, G. I., Atherton, P., Reeds, D. N., Mohammed, B. S., Rankin, D., Rennie, M. J., & Mittendorfer, B. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005611 · Cited by 665 · see citing works
Exercise-induced oxidative stress: Friend or foe?
Powers, S. K., Deminice, R., Ozdemir, M., Yoshihara, T., Bomkamp, M. P., & Hyatt, H. (2020) · Journal of Sport and Health Science · doi:10.1016/j.jshs.2020.04.001 · Cited by 655 · see citing works
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
Zhang, L. J., Pitcher, L. E., Prahalad, V., Niedernhofer, L. J., & Robbins, P. D. (2022) · FEBS Journal · doi:10.1111/febs.16350 · Cited by 648 · see citing works
Ferrucci, L., Penninx, B. W. J. H., Volpato, S., Harris, T. B., Bandeen‐Roche, K., Balfour, J., Leveille, S. G., Fried, L. P., & Md, J. M. G. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50605.x · Cited by 618 · see citing works
Bauernfeind, F., Bartok, E., Rieger, A., Franchi, L., Núñez, G., & Hornung, V. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100613 · Cited by 617 · see citing works
Redox regulation of PI 3‐kinase signalling via inactivation of PTEN
Leslie, N. R., Bennett, D., Lindsay, Y. E., Stewart, H., Gray, A., & Downes, C. P. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg513 · Cited by 614 · see citing works
Effect of exercise training on chronic inflammation
Beavers, K. M., Brinkley, T. E., & Nicklas, B. J. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.02.069 · Cited by 592 · see citing works
Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585 · see citing works
Endurance Exercise as a Countermeasure for Aging
Lanza, I. R., Short, D. K., Short, K. R., Raghavakaimal, S., Basu, R., Joyner, M. J., McConnell, J. P., & Nair, K. S. (2008) · Diabetes · doi:10.2337/db08-0349 · Cited by 582 · see citing works
Self-citationPaulsen, G., Mikkelsen, U. R., Raastad, T., & Peake, J. M. (2026) · PubMed · doi:10.22029/eir.2012.1668 · Cited by 572 · see citing works
Influence of Resistance Exercise on Lean Body Mass in Aging Adults: A Meta-Analysis
PETERSON, M. D., SEN, A., & GORDON, P. M. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181eb6265 · Cited by 558 · see citing works
Molecular and physiological manifestations and measurement of aging in humans
Khan, S. S., Singer, B. D., & Vaughan, D. E. (2017) · Aging Cell · doi:10.1111/acel.12601 · Cited by 530 · see citing works
Mitochondrial dysfunction and the inflammatory response
López-Armada, M. J., Riveiro-Naveira, R. R., Vaamonde‐García, C., & Valcarcel‐Ares, M. N. (2013) · Mitochondrion · doi:10.1016/j.mito.2013.01.003 · Cited by 528 · see citing works
Inflammaging: disturbed interplay between autophagy and inflammasomes
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2012) · Aging · doi:10.18632/aging.100444 · Cited by 511 · see citing works
Kuswanto, W. F., Burzyn, D., Panduro, M., Wang, K. K., Jang, Y. C., Wagers, A. J., Benoist, C. O., & Mathis, D. J. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.009 · Cited by 509 · see citing works
Fish oil–derived n−3 PUFA therapy increases muscle mass and function in healthy older adults
Smith, G. I., Julliand, S., Reeds, D. N., Sinacore, D. R., Klein, S., & Mittendorfer, B. (2015) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.105833 · Cited by 507 · see citing works
Chung, H. Y., Kim, D. H., Lee, E. K., Chung, K. W., Chung, S., Lee, B., Seo, A. Y., Chung, J. H., Jung, Y. S., Im, E., et al. (2018) · Aging and Disease · doi:10.14336/ad.2018.0324 · Cited by 495 · see citing works
Resistance exercise decreases skeletal muscle tumor necrosis factor α in frail elderly humans
GREIWE, J. S., CHENG, B., RUBIN, D. C., YARASHESKI, K. E., & SEMENKOVICH, C. F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0274com · Cited by 454 · see citing works
Invited Review: Redox modulation of skeletal muscle contraction: what we know and what we don't
Reid, M. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.2.724 · Cited by 450 · see citing works
Goodpaster, B. H., Chomentowski, P., Ward, B. K., Rossi, A., Glynn, N. W., Delmonico, M. J., Kritchevsky, S. B., Pahor, M., & Newman, A. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90425.2008 · Cited by 446 · see citing works
Source of chronic inflammation in aging
Sanada, F., Taniyama, Y., Muratsu, J., Otsu, R., Shimizu, H., Rakugi, H., & Morishita, R. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00012 · Cited by 413 · see citing works
Irrcher, I., Ljubicic, V., & Hood, D. A. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00267.2007 · Cited by 356 · see citing works
Aging is accompanied by a blunted muscle protein synthetic response to protein ingestion
Wall, B. T., Gorissen, S. H., Pennings, B., Koopman, R., Groen, B. B. L., Verdijk, L. B., & van Loon, L. J. C. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140903 · Cited by 352 · see citing works
Aging impairs contraction-induced human skeletal muscle mtorc1 signaling and protein synthesis
Fry, C. S., Drummond, M. J., Glynn, E. L., Dickinson, J. M., Gundermann, D. M., Timmerman, K. L., Walker, D. K., Dhanani, S., Volpi, E., & Rasmussen, B. B. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-11 · Cited by 351 · see citing works
Handschin, C., Choi, C. S., Chin, S., Kim, S., Kawamori, D., Kurpad, A. J., Neubauer, N., Hu, J., Mootha, V. K., Kim, Y.-B., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31785 · Cited by 335 · see citing works
Exercise modulates oxidative stress and inflammation in aging and cardiovascular diseases
Sallam, N., & Laher, I. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/7239639 · Cited by 334 · see citing works
Reduced physical activity increases intermuscular adipose tissue in healthy young adults
Manini, T. M., Clark, B. C., Nalls, M. A., Goodpaster, B. H., Ploutz-Snyder, L. L., & Harris, T. B. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.2.377 · Cited by 332 · see citing works
Vissers, D., Hens, W., Taeymans, J., Baeyens, J.-P., Poortmans, J., & Van Gaal, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056415 · Cited by 331 · see citing works
Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?
Merry, T. L., & Ristow, M. (2015) · The Journal of Physiology · doi:10.1113/jp270654 · Cited by 326 · see citing works
New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., et al. (2022) · Aging · doi:10.18632/aging.204248 · Cited by 319 · see citing works
The Inflammation Hypothesis of Aging: Molecular Modulation by Calorie Restriction
Chung, H. Y., Kim, H. J., Kim, J. W., & Yu, B. P. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb05662.x · Cited by 305 · see citing works
Salminen, A., Ojala, J. O., Kaarniranta, K., & Kauppinen, A. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-0962-0 · Cited by 304 · see citing works
Chronic inflammation and the effect of IGF-I on muscle strength and power in older persons
Barbieri, M., Ferrucci, L., Ragno, E., Corsi, A., Bandinelli, S., Bonafè, M., Olivieri, F., Giovagnetti, S., Franceschi, C., Guralnik, J. M., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00319.2002 · Cited by 303 · see citing works
The effect of physical activity on mediators of inflammation
Nimmo, M. A., Leggate, M., Viana, J. L., & King, J. A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12156 · Cited by 301 · see citing works
Ling, C., Poulsen, P., Carlsson, E., Ridderstråle, M., Almgren, P., Wojtaszewski, J., Beck-Nielsen, H., Groop, L., & Vaag, A. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21889 · Cited by 300 · see citing works
Molecular inflammation hypothesis of aging based on the anti‐aging mechanism of calorie restriction
Chung, H. Y., Kim, H. J., Kim, K. W., Choi, J. S., & Yu, B. P. (2002) · Microscopy Research and Technique · doi:10.1002/jemt.10203 · Cited by 297 · see citing works
Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis
Trappe, T. A., White, F., Lambert, C. P., Cesar, D., Hellerstein, M., & Evans, W. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00352.2001 · Cited by 293 · see citing works
Phillips, T., & Leeuwenburgh, C. (2005) · The FASEB Journal · doi:10.1096/fj.04-2870fje · Cited by 283 · see citing works
Roberts, E. T., Haan, M. N., Dowd, J. B., & Aiello, A. E. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq177 · Cited by 281 · see citing works
Zhang, C., Li, Y., Wu, Y., Wang, L., Wang, X., & Du, J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.419788 · Cited by 279 · cited 2× · see citing works
“This inflammatory environment appears crucial for recovery, as pre-clinical studies show that skeletal muscle regenerative capacity is impaired in the absence of TNFα, IL6, or IFN-γ (Peake et al., 2017; Serrano et al., 2008; Zhang et al., 2013; Collins and Grounds, 2001).”
BackgroundThe Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases
Zapata, H. J., & Quagliarello, V. J. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13310 · Cited by 279 · see citing works
Bartlett, D. B., Firth, C. M., Phillips, A. C., Moss, P., Baylis, D., Syddall, H., Sayer, A. A., Cooper, C., & Lord, J. M. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00849.x · Cited by 278 · see citing works
Fish-oil supplementation enhances the effects of strength training in elderly women
Rodacki, C. L., Rodacki, A. L., Pereira, G., Naliwaiko, K., Coelho, I., Pequito, D., & Fernandes, L. C. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.021915 · Cited by 274 · see citing works
Intramuscular and Liver Triglycerides Are Increased in the Elderly
Cree‐Green, M., Newcomer, B. R., Katsanos, C. S., Sheffield‐Moore, M., Chinkes, D. L., Aarsland, A. A., Urban, R. J., & Wolfe, R. R. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031986 · Cited by 273 · see citing works
Tsai, P., Ka, S., Chang, J., Chen, H., Shui, H., Li, C., Hua, K., Chang, W.-L., Huang, J., Yang, S., et al. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.016 · Cited by 268 · see citing works
TNF-α impairs heart and skeletal muscle protein synthesis by altering translation initiation
Lang, C. H., Frost, R. A., Nairn, A. C., MacLean, D. A., & Vary, T. C. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00366.2001 · Cited by 265 · see citing works
Duggal, N. A., Pollock, R. D., Lazarus, N. R., Harridge, S., & Lord, J. M. (2018) · Aging Cell · doi:10.1111/acel.12750 · Cited by 261 · see citing works
Effect of Age on Muscle Hypertrophy Induced by Resistance Training
Welle, S. L., Totterman, S. M. S., & Thornton, C. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.6.m270 · Cited by 247 · see citing works
Expression of interleukin-18 is increased in the brains of Alzheimer’s disease patients
Ojala, J., Alafuzoff, I., Herukka, S.-K., van Groen, T., Tanila, H., & Pirttilä, T. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.06.006 · Cited by 235 · see citing works
Physical inactivity and obesity underlie the insulin resistance of aging
Amati, F., Dubé, J. J., Coen, P. M., Stefanovic-Racic, M., Toledo, F. G. S., & Goodpaster, B. H. (2009) · Diabetes Care · doi:10.2337/dc09-0267 · Cited by 230 · see citing works
Varma, V., Yao-Borengasser, A., Rasouli, N., Nolen, G. T., Phanavanh, B., Starks, T., Gurley, C., Simpson, P., McGehee, R. E., Kern, P. A., et al. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90885.2008 · Cited by 229 · see citing works
Fujita, S., Rasmussen, B. B., Cadenas, J. G., Drummond, M. J., Glynn, E. L., Sattler, F. R., & Volpi, E. (2007) · Diabetes · doi:10.2337/db06-1566 · Cited by 224 · see citing works
Characterization of cellular senescence in aging skeletal muscle
Zhang, X., Habiballa, L., Aversa, Z., Ng, Y. E., Sakamoto, A. E., Englund, D. A., Pearsall, V. M., White, T. A., Robinson, M. M., Rivas, D. A., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00250-8 · Cited by 206 · cited 1× · see citing works
“nucleated fiber and improvements in grip strength (Zhang et al., 2022).”
BackgroundSelf-citationWang, Y., Wehling‐Henricks, M., Samengo, G., & Tidball, J. G. (2015) · Aging Cell · doi:10.1111/acel.12350 · Cited by 205 · see citing works
Gender Differences in Resistance-Training-Induced Myofiber Hypertrophy Among Older Adults
Bamman, M. M., Hill, V. J., Adams, G. R., Haddad, F., Wetzstein, C. J., Gower, B. A., Ahmed, A., & Hunter, G. R. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.2.b108 · Cited by 199 · see citing works
Trappe, T. A., Carroll, C. C., Dickinson, J. M., LeMoine, J. K., Haus, J. M., Sullivan, B. E., Lee, J. D., Jemioło, B., Weinheimer-Haus, E. M., & Hollon, C. J. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00611.2010 · Cited by 196 · see citing works
Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans
Sachs, S., Zarini, S., Kahn, D. E., Harrison, K. A., Perreault, L., Phang, T., Newsom, S. A., Strauss, A., Kerege, A., Schoen, J. A., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00243.2018 · Cited by 192 · see citing works
Peake, J. M., Gatta, P. A. D., & Cameron‐Smith, D. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00467.2009 · Cited by 182 · see citing works
Rieu, I., Magne, H., Savary‐Auzeloux, I., Avérous, J., Bos, C., Peyron, M., Combaret, L., & Dardevet, D. P. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.178319 · Cited by 182 · see citing works
Aerobic fitness is associated with lower proportions of senescent blood T-cells in man
Spielmann, G., McFarlin, B. K., O’Connor, D. P., Smith, P. J. W., Pircher, H., & Simpson, R. J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.226 · Cited by 180 · see citing works
Senescence of the Human Immune System
Pawelec, G., Larbi, A., & Derhovanessian, E. (2009) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2009.09.005 · Cited by 180 · see citing works
Inflammasome Up-Regulation and Activation in Dysferlin-Deficient Skeletal Muscle
Rawat, R., Cohen, T. V., Ampong, B., Francia, D., Henriques‐Pons, A., Hoffman, E. P., & Nagaraju, K. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090058 · Cited by 176 · see citing works
Vogelpoel, L. T. C., Hansen, I. S., Rispens, T., Muller, F. J. M., van Capel, T. M. M., Turina, M. C., Vos, J. B., Baeten, D., Kapsenberg, M. L., de Jong, E. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6444 · Cited by 173 · see citing works
Role and potential mechanisms of anabolic resistance in sarcopenia
Haran, P. H., Rivas, D. A., & Fielding, R. A. (2012) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-012-0068-4 · Cited by 172 · see citing works
Toth, M. J., Matthews, D. E., Tracy, R. P., & Previs, M. J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00353.2004 · Cited by 169 · see citing works
Lalia, A. Z., Dasari, S., Robinson, M. M., Abid, H., Morse, D. M., Klaus, K. A., & Lanza, I. R. (2017) · Aging · doi:10.18632/aging.101210 · Cited by 163 · see citing works
Self-citationAntioxidant and Adaptative Response Mediated by Nrf2 during Physical Exercise
Vargas-Mendoza, N., Morales‐González, Á., Madrigal‐Santillán, E., Madrigal‐Bujaidar, E., Álvarez‐González, I., García-Melo, L. F., Anguiano‐Robledo, L., Fregoso-Aguilar, T. A., & Morales‐González, J. A. (2019) · Antioxidants · doi:10.3390/antiox8060196 · Cited by 163 · see citing works
Kunz, H., Hart, C. R., Gries, K. J., Parvizi, M., LAURENTI, M. C., Man, C. D., Moore, N., Zhang, X., Ryan, Z., Polley, E. C., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00070.2021 · Cited by 163 · see citing works
Self-citationThe Role of Tumor Necrosis Factor-alpha (TNF-α) in Skeletal Muscle Regeneration
Collins, R. A., & Grounds, M. D. (2001) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215540104900807 · Cited by 161 · see citing works
Przybyla, B., Gurley, C., Harvey, J. F., Bearden, E., Kortebein, P., Evans, W., Sullivan, D., Peterson, C. A., & Dennis, R. (2006) · Experimental Gerontology · doi:10.1016/j.exger.2005.12.007 · Cited by 158 · see citing works
Logan, S. L., & Spriet, L. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144828 · Cited by 155 · see citing works
Sarcopenia and Its Implications for Metabolic Health
Hunter, G. R., Singh, H., Carter, S. J., Bryan, D. R., & Fisher, G. (2019) · Journal of Obesity · doi:10.1155/2019/8031705 · Cited by 153 · see citing works
Muscle mitochondrial changes with aging and exercise
Lanza, I. R., & Nair, K. S. (2008) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26717d · Cited by 152 · see citing works
Self-citationKoltai, E., Hart, N., Taylor, A. W., Goto, S., Ngo, J. K., Davies, K. J. A., & Radak, Z. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00337.2011 · Cited by 152 · see citing works
Exercise and the Regulation of Inflammatory Responses
Allen, J. M., Sun, Y., & Woods, J. A. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2015.07.003 · Cited by 150 · see citing works
Elevated Muscle TLR4 Expression and Metabolic Endotoxemia in Human Aging
Ghosh, S., Lertwattanarak, R., Garduno, J. D. J., Galeana, J. J., Li, J., Zamarripa, F., Lancaster, J. L., Mohan, S., Hussey, S., & Musi, N. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu067 · Cited by 150 · see citing works
Effects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation
Lavin, K. M., Perkins, R. K., Jemioło, B., Raue, U., Trappe, S. W., & Trappe, T. A. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00495.2019 · Cited by 150 · see citing works
The physiopathologic role of oxidative stress in skeletal muscle
Scicchitano, B. M., Pelosi, L., Sica, G., & Musarò, A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.009 · Cited by 141 · see citing works
Combined Training Enhances Skeletal Muscle Mitochondrial Oxidative Capacity Independent of Age
Irving, B. A., Lanza, I. R., Henderson, G. C., Rao, R. R., Spiegelman, B. M., & Nair, K. S. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-3081 · Cited by 139 · see citing works
Self-citationEffects of short‐term endurance exercise on gut microbiota in elderly men
Taniguchi, H., Tanisawa, K., Sun, X., Kubo, T., Hoshino, Y., Hosokawa, M., Takeyama, H., & Higuchi, M. (2018) · Physiological Reports · doi:10.14814/phy2.13935 · Cited by 137 · see citing works
Holloway, G. P., Holwerda, A. M., Miotto, P. M., Dirks, M. L., Verdijk, L. B., & van Loon, L. J. C. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.02.069 · Cited by 134 · see citing works
Muire, P. J., Mangum, L. H., & Wenke, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01056 · Cited by 134 · see citing works
Spyridopoulos, I., Martin‐Ruiz, C., Hilkens, C., Yadegarfar, M. E., Isaacs, J., Jagger, C., Kirkwood, T., & von Zglinicki, T. (2016) · Aging Cell · doi:10.1111/acel.12430 · Cited by 133 · see citing works
Exercise reduces circulating biomarkers of cellular senescence in humans
Englund, D. A., Sakamoto, A. E., Fritsche, C. M., Heeren, A. A., Zhang, X., Kotajarvi, B. R., Lecy, D. R., Yousefzadeh, M. J., Schafer, M. J., White, T. A., et al. (2021) · Aging Cell · doi:10.1111/acel.13415 · Cited by 125 · see citing works
Frailty has a stronger association with inflammation than age in older veterans
Epps, P. V., Oswald, D., Higgins, P. A., Hornick, T. R., Aung, H., Banks, R. E., Wilson, B. M., Burant, C., Gravenstein, S., & Canaday, D. H. (2016) · Immunity & Ageing · doi:10.1186/s12979-016-0082-z · Cited by 124 · see citing works
Exercise and intestinal permeability: another form of exercise-induced hormesis?
Keirns, B. H., Koemel, N. A., Sciarrillo, C. M., Anderson, K. L., & Emerson, S. R. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00232.2020 · Cited by 121 · see citing works
Inflammaging and Skeletal Muscle: Can Protein Intake Make a Difference?
Draganidis, D., Karagounis, L. G., Athanailidis, I., Chatzinikolaou, A., Jamurtas, A. Z., & Fatouros, I. G. (2016) · Journal of Nutrition · doi:10.3945/jn.116.230912 · Cited by 120 · see citing works
Physical Exercise: A Novel Tool to Protect Mitochondrial Health
Sorriento, D., Di Vaia, E., & Iaccarino, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.660068 · Cited by 118 · see citing works
Skewed macrophage polarization in aging skeletal muscle
Cui, C., Driscoll, R. K., Piao, Y., Chia, C. W., Gorospe, M., & Ferrucci, L. (2019) · Aging Cell · doi:10.1111/acel.13032 · Cited by 117 · see citing works
Abbatecola, A. M., Ferrucci, L., Grella, R., Bandinelli, S., Bonafè, M., Barbieri, M., Corsi, A. M., Lauretani, F., Franceschi, C., & Paolisso, G. (2004) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2004.52112.x · Cited by 116 · see citing works
Kuo, H.-K., Bean, J. F., Yen, C.-J., & Leveille, S. G. (2006) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/61.4.380 · Cited by 115 · see citing works
Lira, F. S., Rosa, J. C., Pimentel, G. D., Souza, H. A., Caperuto, E. C., Carnevali, L. C., Seelaender, M., Damaso, A. R., Oyama, L. M., de Mello, M. T., et al. (2010) · Lipids in Health and Disease · doi:10.1186/1476-511x-9-82 · Cited by 112 · see citing works
DAMPs and inflammatory processes: the role of redox in the different outcomes
Carta, S., Castellani, P., Delfino, L., Tassi, S., Venè, R., & Rubartelli, A. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1008598 · Cited by 112 · see citing works
Flynn, M. G., Markofski, M. M., & Carrillo, A. E. (2018) · Aging and Disease · doi:10.14336/ad.2018.0326 · Cited by 111 · see citing works
Inflammation and Thrombosis Biomarkers and Incident Frailty in Postmenopausal Women
Reiner, A. P., Aragaki, A. K., Gray, S. L., Wactawski‐Wende, J., Cauley, J. A., Cochrane, B. B., Kooperberg, C. L., Woods, N. F., & LaCroix, A. Z. (2009) · The American Journal of Medicine · doi:10.1016/j.amjmed.2009.04.016 · Cited by 108 · see citing works
Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice
Dungan, C. M., Murach, K. A., Zdunek, C. J., Tang, Z. J., Nolt, G. L., Brightwell, C. R., Hettinger, Z. R., Englund, D. A., Liu, Z., Fry, C. S., et al. (2021) · Aging Cell · doi:10.1111/acel.13528 · Cited by 105 · see citing works
Inflammaging markers characteristic of advanced age show similar levels with frailty and dependency
Alberro, A., Iribarren-López, A., Sáenz-Cuesta, M., Matheu, A., Vergara, I., & Otaegui, D. (2021) · Scientific Reports · doi:10.1038/s41598-021-83991-7 · Cited by 102 · see citing works
Effect of exercise training on skeletal muscle cytokine expression in the elderly
Gatta, P. A. D., GARNHAM, A. P., Peake, J. M., & Cameron‐Smith, D. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.01.006 · Cited by 101 · see citing works
Moratal, C., Raffort, J., Arrighi, N., Rekima, S., Schaub, S., Dechesne, C. A., Chinetti, G., & Dani, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-35429-w · Cited by 101 · see citing works
Krzymińska-Siemaszko, R., Czepulis, N., Lewandowicz, M., Zasadzka, E., Suwalska, A., Witowski, J., & Wieczorowska–Tobis, K. (2015) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph120910558 · Cited by 99 · see citing works
Thalacker‐Mercer, A. E., Dell’Italia, L. J., Cui, X., Cross, J. M., & Bamman, M. M. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00151.2009 · Cited by 99 · see citing works
Walton, R. G., Kosmac, K., Mula, J., Fry, C. S., Peck, B. D., Groshong, J. S., Finlin, B. S., Zhu, B., Kern, P. A., & Peterson, C. A. (2019) · Scientific Reports · doi:10.1038/s41598-018-37187-1 · Cited by 97 · see citing works
Pathogen-Induced Interleukin-1β Processing and Secretion Is Regulated by a Biphasic Redox Response
Tassi, S., Carta, S., Venè, R., Delfino, L., Ciriolo, M. R., & Rubartelli, A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900578 · Cited by 96 · see citing works
Strandberg, E., Edholm, P., Ponsot, E., Wåhlin‐Larsson, B., Hellmén, E., Nilsson, A. E., Engfeldt, P., Cederholm, T., Risérus, U., & Kadi, F. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00066.2015 · Cited by 89 · see citing works
Physiological adaptations to resistance exercise as a function of age
Phillips, B., Williams, J. P., Greenhaff, P., Smith, K., & Atherton, P. (2017) · JCI Insight · doi:10.1172/jci.insight.95581 · Cited by 86 · see citing works
Ibuprofen and Acetaminophen: Effect on Muscle Inflammation after Eccentric Exercise
PETERSON, J. M., TRAPPE, T. A., MYLONA, E., WHITE, F., LAMBERT, C. P., EVANS, W. J., & PIZZA, F. X. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000069917.51742.98 · Cited by 85 · see citing works
Mechanistic Links Underlying the Impact of C-Reactive Protein on Muscle Mass in Elderly
Wåhlin‐Larsson, B., Wilkinson, D. J., Strandberg, E., Hosford-Donovan, A., Atherton, P. J., & Kadi, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000484679 · Cited by 81 · see citing works
Cornish, S. M., Cordingley, D. M., Shaw, K. A., Forbes, S. C., Leonhardt, T. P. M., Bristol, A., Candow, D. G., & Chilibeck, P. D. (2022) · Nutrients · doi:10.3390/nu14112221 · Cited by 80 · see citing works
Effects of Age and Sedentary Lifestyle on Skeletal Muscle NF- B Signaling in Men
Buford, T. W., Cooke, M. B., Manini, T. M., Leeuwenburgh, C., & Willoughby, D. S. (2010) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glp196 · Cited by 78 · see citing works
Ramos, C., Gibson, G. R., Walton, G., Magistro, D., Kinnear, W., & Hunter, K. A. (2022) · Nutrients · doi:10.3390/nu14030674 · Cited by 78 · see citing works
Correa, B. L., Ornaghi, A. P., Müller, G. C., Engroff, P., Lopes, R. P., Filho, I. G. D. S., Bosch, J. A., Bonorino, C., & Bauer, M. E. (2014) · NeuroImmunoModulation · doi:10.1159/000356827 · Cited by 69 · see citing works
Effect of an 8-week Exercise Training on Gut Microbiota in Physically Inactive Older Women
Zhong, F., Xu, W., Yang, M., Lai, H., Momma, H., Cheng, L., Sun, X., Nagatomi, R., & Huang, C. X. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1301-7011 · Cited by 67 · see citing works
Neutrophil Depletion Attenuates Muscle Injury after Exhaustive Exercise
Kawanishi, N., Mizokami, T., NIIHARA, H., Yada, K., & Suzuki, K. (2016) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000980 · Cited by 65 · see citing works
Senolytic treatment rescues blunted muscle hypertrophy in old mice
Dungan, C. M., Figueiredo, V. C., Wen, Y., VonLehmden, G. L., Zdunek, C. J., Thomas, N. T., Mobley, C. B., Murach, K. A., Brightwell, C. R., Long, D. E., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00542-2 · Cited by 65 · see citing works
Alkhedhairi, S. A., Aba Alkhayl, F. F., Ismail, A. D., Rozendaal, A., German, M., MacLean, B., Johnston, L., Miller, A. A., Hunter, A. M., Macgregor, L. J., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.04.007 · Cited by 56 · see citing works
Exercise-Induced Activation of STAT3 Signaling Is Increased with Age
Caldow, M. K., Carey, K. A., Ward, A. C., Farnfield, M. M., & Cameron‐Smith, D. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0643 · Cited by 55 · see citing works
Edholm, P., Strandberg, E., & Kadi, F. (2017) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00924.2016 · Cited by 49 · see citing works
Čížková, T., Štěpán, M., Daďová, K., Ondrůjová, B., Sontáková, L., Krauzová, E., Matouš, M., Koc, M., Gojda, J., Kračmerová, J., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa630 · Cited by 46 · see citing works
Beyond adjuvants: Antagonizing inflammation to enhance vaccine immunity
Alter, G., & Sékaly, R. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.058 · Cited by 44 · see citing works
Exercise as a countermeasure for latent viral reactivation during long duration space flight
Agha, N. H., Mehta, S. K., Rooney, B. V., Laughlin, M. S., Markofski, M. M., Pierson, D. L., Katsanis, E., Crucian, B. E., & Simpson, R. J. (2020) · The FASEB Journal · doi:10.1096/fj.201902327r · Cited by 43 · see citing works
Hart, C. R., Ryan, Z. C., Pfaffenbach, K. T., Dasari, S., Parvizi, M., Lalia, A. Z., & Lanza, I. R. (2019) · Aging · doi:10.18632/aging.102273 · Cited by 39 · see citing works
Self-citationEffects of aging and lifelong aerobic exercise on basal and exercise-induced inflammation in women
Lavin, K. M., Perkins, R. K., Jemioło, B., Raue, U., Trappe, S. W., & Trappe, T. A. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00655.2020 · Cited by 36 · see citing works
Sorensen, J. R., Kaluhiokalani, J. P., Hafen, P. S., Deyhle, M. R., Parcell, A. C., & Hyldahl, R. D. (2019) · The FASEB Journal · doi:10.1096/fj.201900519r · Cited by 35 · see citing works
Macrophages in skeletal muscle aging
Cui, C., & Ferrucci, L. (2020) · Aging · doi:10.18632/aging.102740 · Cited by 35 · see citing works
Sparks, L. M., Goodpaster, B. H., & Bergman, B. C. (2021) · Diabetes · doi:10.2337/dbi19-0006 · Cited by 35 · see citing works
Jensen, S. M., Bechshøft, C. J. L., Heisterberg, M. F., Schjerling, P., Andersen, J. L., Kjær, M., & Mackey, A. L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00811 · Cited by 33 · see citing works
Garritson, J. D., & Boudina, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.772894 · Cited by 32 · see citing works
Goldeck, D., Pawelec, G., Norman, K., Steinhagen-Thiessen, E., Oettinger, L., Haehnel, K., & Demuth, I. (2016) · Biogerontology · doi:10.1007/s10522-015-9577-9 · Cited by 30 · see citing works
Kunz, H., Michie, K. L., Gries, K. J., Zhang, X., Ryan, Z. C., & Lanza, I. R. (2022) · Nutrients · doi:10.3390/nu14173537 · Cited by 29 · see citing works
Self-citationShort-Term and Lifelong Exercise Training Lowers Inflammatory Mediators in Older Men
Hayes, L. D., Herbert, P., Sculthorpe, N. F., & Grace, F. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.702248 · Cited by 23 · see citing works
Lee, H., Kim, I., Sung, C., Jeon, T., Cho, K., Ha, Y., Park, K., Yoo, J., Kang, G. H., Kim, S. J., et al. (2019) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.13597 · Cited by 22 · see citing works
Exercise reduces metabolic burden while altering the immune system in aged mice
Yoon, K. J., Ahn, A., Park, S. H., Kwak, S. H., Kwak, S. E., Lee, W., Yang, Y. R., Kim, M., Shin, H. M., Kim, H., et al. (2021) · Aging · doi:10.18632/aging.202312 · Cited by 22 · see citing works
Borges, I. B. P., de Oliveira, D. S., Marie, S. K. N., Lenario, A. M., Oba‐Shinjo, S. M., & Shinjo, S. K. (2021) · JCR Journal of Clinical Rheumatology · doi:10.1097/rhu.0000000000001721 · Cited by 20 · see citing works
SINGLE-CELL ANALYSIS OF SKELETAL MUSCLE MACROPHAGES REVEALS AGE-ASSOCIATED FUNCTIONAL SUBPOPULATIONS
Cui, C., Krasniewski, L. K., Chakraborty, P., et al. (2022) · Innovation in Aging · doi:10.1093/geroni/igac059.2672 · Cited by 2 · see citing works
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Muñoz López, M., López-Gil, J. F., Ramírez de la piscina Viúdez, X., Baz-Valle, E., & Tornero Aguilera, J. F. (2026) · Cells · doi:10.3390/cells15111041 · Cited by 1 · see citing works
“This cellular infiltration confounder can lead to systemic false-positive interpretations of muscle-specific translational capacity expansion, effectively obscuring the true magnitude of the nucleolar output driving myofibrillar hypertrophy [72,73].”
- Authors
- Kunz, H. E., & Lanza, I. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Lanza, Ian R.
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2023-06
- Volume
- 177
- Pages
- 112177
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W4366742334
- Cited by
- 56
- References
- 169
- Citations by year
- 2026: 18 · 2025: 22 · 2024: 14 · 2023: 2
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Experimental Gerontology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- inflammaging, skeletal muscle aging, exercise training, muscle inflammation, anabolic resistance, muscle atrophy, mitochondrial dysfunction, acute inflammatory response, muscle regeneration, older adults, therapeutic target
- MeSH terms
- Aged, Aging, Anti-Inflammatory Agents, Humans, Inflammation, Exercise, Muscle, Skeletal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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