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Cited by 8Muscle metabolism and nutritionMuscle activation and electromyography studiesSports Performance and Training

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

The Effect of Creatine Loading on Neuromuscular Fatigue in Women

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SMITH-RYAN, ABBIE E., RYAN, ERIC D., FUKUDA, DAVID H., COSTA, PABLO B., CRAMER, JOEL T., STOUT, JEFFREY R.·2014·Medicine & Science in Sports & Exercise
DOI 10.1249/mss.0000000000000194
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Abstract

PURPOSE: This study aimed to examine the effects of intermittent isometric fatigue on maximal voluntary contraction (MVC) strength, percent voluntary activation (%VA), peak twitch force (PTF), peak rate of force development (PRFD), half relaxation time (HRT), and maximal compound action potential (M-wave) amplitude of the soleus and medial gastrocnemius muscles before and after creatine (Cr) loading. METHODS: Using a double-blinded, placebo-controlled, randomized design, 12 women were assigned to a Cr (n = 6; mean age ± SD = 23.3 ± 3.0 yr) or placebo (PL; n = 6; mean age ± SD = 21.3 ± 1.6 yr) group. Participants supplemented four times daily for 5 d with 5 g of Cr + 10 g of fructose or 10 g of fructose. At baseline and after testing, an isometric MVC and the twitch interpolation procedure were used before and after a 4-min isometric fatigue protocol of the plantarflexor muscles, which consisted of six intermittent duty cycles per minute (7-s contraction, 3-s relaxation) at 70% MVC. RESULTS: There were no interactions between the Cr and PL groups (P > 0.05) for any dependent variable. The fatigue protocol reduced voluntary strength (-17.8%, P < 0.001) and %VA (-3.7%, P = 0.005). Baseline PTF (P < 0.005) and PRFD (P < 0.001) values were less than those of all respective time points, but PTF value decreased from 3 min to 4 min and after testing (P < 0.005). HRT increased from baseline to minutes 1 and 2 and then returned to baseline at minutes 3 and 4 and after testing. The M-wave did not change (P > 0.05). CONCLUSIONS: Five days of Cr loading did not influence isometric force, %VA, evoked twitch properties, or the central and peripheral aspects of fatigue measured in this study.

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Crossref · 10.1249/mss.0000000000000194

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Metadata

Authors
SMITH-RYAN, A. E., RYAN, E. D., FUKUDA, D. H., COSTA, P. B., CRAMER, J. T., & STOUT, J. R.
Affiliations
  • University of Central Florida (US)
  • California State University, San Bernardino (US)
  • University of Nebraska–Lincoln (US)
ORCID
Venue
Medicine & Science in Sports & Exercise
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2014-05
Volume
46
Issue
5
Pages
990-997
ISSN
0195-9131 (ISSN-L)
DOI
10.1249/mss.0000000000000194
OpenAlex
W2082869550
Cited by
8
References
45
Citations by year
2026: 2 · 2025: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2017: 1
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
  • Medicine & Science in Sports & Exercise (publishedVersion)
  • PubMed (publishedVersion)
  • Journal of International Crisis and Risk Communication Research (submittedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Keywords
creatine supplementation, creatine loading, neuromuscular fatigue, isometric fatigue, maximal voluntary contraction, voluntary activation, twitch interpolation, rate of force development, half-relaxation time, M-wave, soleus muscle, medial gastrocnemius, plantar flexor muscles, women
MeSH terms
Adult, Creatine, Double-Blind Method, Female, Fructose, Humans, Isometric Contraction, Muscle Relaxation, Sweetening Agents, Body Mass Index, Muscle, Skeletal, Muscle Fatigue, Dietary Supplements, Muscle Strength, Young Adult

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