The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.
Quercetin Reduces Illness but Not Immune Perturbations after Intensive Exercise
Abstract
PURPOSE: To investigate the effects of quercetin supplementation on incidence of upper respiratory tract infections (URTI) and exercise-induced changes in immune function. METHODS: Trained male cyclists (N=40) were randomized to quercetin (N=20) or placebo (N=20) groups and, under double-blind procedures, received 3 wk quercetin (1000 mg.d(-1)) or placebo before, during, and for 2 wk after a 3-d period in which subjects cycled for 3 h.d(-1) at approximately 57% Wmax. Blood and saliva samples were collected before and after each of the three exercise sessions and assayed for natural killer cell activity (NKCA), PHA-stimulated lymphocyte proliferation (PHA-LP), polymorphonuclear oxidative-burst activity (POBA), and salivary IgA output (sIgA). RESULTS: Pre- to postexercise changes in NKCA, PHA-LP, POBA, and sIgA did not differ significantly between quercetin and placebo groups. URTI incidence during the 2-wk postexercise period differed significantly between groups (quercetin=1/20 vs placebo=9/20, Kaplan-Meier analysis statistic=8.31, P=0.004). CONCLUSION: Quercetin versus placebo ingestion did not alter exercise-induced changes in several measures of immune function, but it significantly reduced URTI incidence in cyclists during the 2-wk period after intensified exercise.
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“For example, although self-reported illness symptoms following a period of demanding exercise training have been shown to be lower in athletes supplementing their diet with Quercetin, this antioxidant had no effect on assessments immune function before and after acute exercise (Nieman et al. 2007).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Nieman et al. 2007
Citations
Cites
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Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
Manach, C., Morand, C., Crespy, V., Demigné, C., Texier, O., Regerat, F., & Rémésy, C. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00367-6 · Cited by 586
Tissue Distribution of Quercetin in Rats and Pigs
de Boer, V. C. J., Dihal, A. A., van der Woude, H., Arts, I. C. W., Wolffram, S., Alink, G. M., Rietjens, I. M. C. M., Keijer, J., & Hollman, P. C. H. (2005) · Journal of Nutrition · doi:10.1093/jn/135.7.1718 · Cited by 519
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Cited by
Sorted by citations
Quercetin, Inflammation and Immunity
Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M., Wang, S., Liu, H., & Yin, Y. (2016) · Nutrients · doi:10.3390/nu8030167 · Cited by 1,999
“1000 mg/day Human cyclist No effect [74]”
BackgroundIOC Consensus Statement: Dietary Supplements and the High-performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · British Journal of Sports Medicine · doi:10.1136/bjsports-2018-099027 · Cited by 1,004
RETRACTED: Quercetin: A flavonol with multifaceted therapeutic applications?
D’Andrea, G. (2015) · Fitoterapia · doi:10.1016/j.fitote.2015.09.018 · Cited by 743
RetractedIOC Consensus Statement: Dietary Supplements and the High-Performance Athlete
Maughan, R. J., Burke, L. M., Dvorak, J., Larson-Meyer, D. E., Peeling, P., Phillips, S. M., Rawson, E. S., Walsh, N. P., Garthe, I., Geyer, H., et al. (2018) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0020 · Cited by 540
“Further support required (Gleeson, 2016; Nieman et al., 2007).”
BackgroundBiancatelli, R. M. L. C., Berrill, M., Catravas, J. D., & Marik, P. E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01451 · Cited by 533
“Athletes supplemented with quercetin are protected from stress-induced susceptibility to upper respiratory tract infection (44)—which was not related to immunomodulation (45, 46).”
Background
Metadata
- Authors
- NIEMAN, D. C., HENSON, D. A., GROSS, S. J., JENKINS, D. P., DAVIS, J. M., MURPHY, E. A., CARMICHAEL, M. D., DUMKE, C. L., UTTER, A. C., MCANULTY, S. R., MCANULTY, L. S., & MAYER, E. P.
- Affiliations
- Appalachian State University (US)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2007-09
- Volume
- 39
- Issue
- 9
- Pages
- 1561-1569
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2100065198
- Cited by
- 193
- References
- 35
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 3 · 2023: 7 · 2022: 8 · 2021: 15 · 2020: 13 · 2019: 3 · 2018: 6 · 2017: 9 · 2016: 9 · 2015: 9 · 2014: 12 · 2013: 20 · 2012: 12
- FWCI
- 13.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Herbal Medicine Research Studies
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- quercetin, upper respiratory tract infection, exercise immunology, NK cell cytotoxicity, lymphocyte proliferation, neutrophil respiratory burst, salivary IgA, antioxidant supplementation, cyclists, disease incidence
- MeSH terms
- Adult, Antioxidants, Physical Exertion, Humans, Immune System, Killer Cells, Natural, Male, Peroxidase, Neutrophils, Quercetin, Respiratory Tract Infections, T-Lymphocytes, Exercise
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