Endurance training modulates lymphocyte function in rats with post-MI CHF
Open accessAbstract
PURPOSE: Exercise training restores innate immune system cell function in post-myocardial infarction (post-MI) rats. However, studies of the involvement of lymphocyte (Ly) in the setting of the congestive heart failure (CHF) are few. To address this issue, we investigated the function of Ly obtained from cervical lymph nodes from post-MI CHF rats submitted to treadmill running training. METHODS: Twenty-five male Wistar rats were randomly assigned to the following groups: rats submitted to ligation of the left coronary artery, which were sedentary (MI-S, N = 7, only limited activity) or trained (MI-T, N = 6, on a treadmill (0% grade at 13-20 m.m) for 60 min.d, 5 d.wk, for 8-10 wk); or sham-operated rats, which were sedentary (sham-S, N = 6) or trained (sham-T, N = 6). The incorporation of [2-C]-thymidine by Ly cultivated in the presence of concanavalin A (Con A) and lipopolysaccharide (LPS), cytokine production by Ly cultivated in the presence of phytohemagglutinin (PHA), and plasma concentration of glutamine were assessed in all groups, 48 h after the last exercise session. RESULTS: Proliferative capacity was increased, following incubation with Con-A in the MI groups, when compared with the sham counterparts. When incubated in the presence of PHA, MI-S produced more IL-4 (96%) than sham-S (P < 0.001). The training protocol induced a 2.2-fold increase in the production of interleukin-2 (P < 0.001) of the cells obtained from the cervical lymph nodes of MI-T, compared with MI-S. CONCLUSION: The moderate endurance training protocol caused an increase in IL-2 production, and a trend toward the reversion of the Th1/Th2 imbalance associated with IL-4 production increased in the post-MI CHF animal model.
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“, 2010) and (6) increased cardiac function (Barauna et al., 2005; Laterza et al., 2007; Batista et al., 2008).”
BackgroundSelf-citationExercise training changes IL-10/TNF-α ratio in the skeletal muscle of post-MI rats
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Self-citationChronic exercise decreases cytokine production in healthy rat skeletal muscle
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- Authors
- BATISTA, M. L., SANTOS, R. V. T., LOPES, R. D., LOPES, A. C., COSTA ROSA, L. F. B. P., & SEELAENDER, M. C. L.
- Affiliations
- Universidade de São Paulo (BR)
- Universidade Federal de São Paulo (BR)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2008-03
- Volume
- 40
- Issue
- 3
- Pages
- 549-556
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2089556703
- Cited by
- 19
- References
- 38
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2013: 2
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- green
- americanae.aecid.es
- Licence
- other-oa
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Americanae (AECID Library) (submittedVersion, other-oa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- endurance training, lymphocyte function, congestive heart failure, myocardial infarction, treadmill running, cervical lymph nodes, lymphocyte proliferation, interleukin-2, IL-4, Th1/Th2 balance, innate immunity, glutamine, cytokine production
- MeSH terms
- Animals, Glutamine, Heart Failure, Lymphocytes, Male, Myocardial Infarction, Physical Conditioning, Animal, Physical Endurance, Random Allocation, Rats, Wistar, Rats
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