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Cited by 117Exercise and Physiological ResponsesCardiac Fibrosis and RemodelingCardiovascular and exercise physiology

Exercise training changes IL-10/TNF-α ratio in the skeletal muscle of post-MI rats

Batista Jr., M.L., Rosa, J.C., Lopes, R.D., Lira, F.S., Martins Jr., E., Yamashita, A.S., Brum, P.C., Lancha Jr., A.H. +2 more·2010·Cytokine
DOI 10.1016/j.cyto.2009.10.007
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Abstract

Heart failure (HF) is associated with changes in the skeletal muscle (SM) which might be a consequence of the unbalanced local expression of pro- (TNF-alpha) and anti- (IL-10) inflammatory cytokines, leading to inflammation-induced myopathy, and SM wasting. This local effect of HF on SM may, on the other hand, contribute to systemic inflammation, as this tissue actively secretes cytokines. Since increasing evidence points out to an anti-inflammatory effect of exercise training, the goal of the present study was to investigate its effect in rats with HF after post-myocardial infarction (MI), with special regard to the expression of TNF-alpha and IL-10 in the soleus and extensor digitorum longus (EDL), muscles with different fiber composition. Wistar rats underwent left thoracotomy with ligation of the left coronary artery, and were randomly assigned to either a sedentary (Sham-operated and MI sedentary) or trained (Sham-operated and MI trained) group. Animals in the trained groups ran on a treadmill (0% grade at 13-20 m/min) for 60 min/day, 5 days/week, for 8-10 weeks. The training protocol was able to reverse the changes induced by MI, decreasing TNF-alpha protein (26%, P<0.05) and mRNA (58%, P<0.05) levels in the soleus, when compared with the sedentary MI group. Training also increased soleus IL-10 expression (2.6-fold, P<0.001) in post-MI HF rats. As a consequence, the IL-10/TNF-alpha ratio was increased. This "anti-inflammatory effect" was more pronounced in the soleus than in the EDL, suggesting a fiber composition dependent response.

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Authors
Batista Jr., M. L., Rosa, J. C., Lopes, R. D., Lira, F. S., Martins Jr., E., Yamashita, A. S., Brum, P. C., Lancha Jr., A. H., Lopes, A. C., & Seelaender, M.
Affiliations
  • Universidade de São Paulo (BR)
  • Universidade Federal de São Paulo (BR)
ORCID
Venue
Cytokine
Publisher
Elsevier BV
Published
2010-01
Volume
49
Issue
1
Pages
102-108
ISSN
1043-4666 (ISSN-L)
DOI
10.1016/j.cyto.2009.10.007
OpenAlex
W1977169152
Cited by
117
References
39
Citations by year
2026: 3 · 2025: 6 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 13 · 2019: 5 · 2018: 6 · 2017: 10 · 2016: 8 · 2015: 9 · 2014: 14 · 2013: 3 · 2012: 9
FWCI
6.11
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Cytokine (publishedVersion)
  • PubMed (publishedVersion)
  • Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
exercise training, myocardial infarction, heart failure, skeletal muscle, IL-10, TNF-α, IL-10/TNF-α ratio, inflammation, soleus muscle, extensor digitorum longus, muscle fiber composition, treadmill running, anti-inflammatory activity
MeSH terms
Animals, Body Weight, Echocardiography, Heart Failure, Male, Myocardial Infarction, Organ Size, Physical Conditioning, Animal, Random Allocation, Tumor Necrosis Factor-alpha, Interleukin-10, Rats, Wistar, Muscle, Skeletal, Rats

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