Training Surface and Intensity: Inflammation, Hemolysis, and Hepcidin Expression
Abstract
PURPOSE: This investigation assessed the effects of training intensity and ground surface type on hemolysis, inflammation, and hepcidin activity during running. METHODS: Ten highly trained male endurance athletes completed a graded exercise test, two continuous 10-km runs on a grass (GRASS) and a bitumen road surface (ROAD) at 75%-80% peak VO2 running velocity, and a 10 x 1-km interval running session (INT) at 90%-95% of the peak VO2 running velocity. Venous blood and urine samples were collected before, immediately after, and at 3 and 24 h after exercise. Serum samples were analyzed for circulating levels of IL-6, free hemoglobin (Hb), haptoglobin (Hp), iron, and ferritin. Urine samples were analyzed for changes in hepcidin expression. RESULTS: After running, the IL-6 and free Hb were significantly greater, and serum Hp was significantly lower than preexercise values in all three conditions (P < 0.05). Furthermore, IL-6 levels and the change in free Hb from baseline were significantly greater in the INT compared with those in the GRASS (P < 0.05). There were no differences between the GRASS and ROAD training surfaces (P > 0.05). Serum iron and ferritin were significantly increased after exercise in all three conditions (P < 0.05) but were not different between trials. CONCLUSION: Greater running intensities incur more inflammation and hemolysis, but these variables were not affected by the surface type trained upon.
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These prevalence rates are linked to sex differences, poor dietary intake, exercise-induced iron losses, and menstrual cycle perturbations of iron regulation.
“These prevalence rates are linked to sex differences [317], poor dietary intake, exercise-induced iron losses, and menstrual cycle perturbations of iron regulation [38,318,319].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [317]
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- Authors
- PEELING, P., DAWSON, B., GOODMAN, C., LANDERS, G., WIEGERINCK, E. T., SWINKELS, D. W., & TRINDER, D.
- Affiliations
- The University of Western Australia (AU)
- Radboud University Nijmegen (NL)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2009-05
- Volume
- 41
- Issue
- 5
- Pages
- 1138-1145
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2111295265
- Cited by
- 107
- References
- 37
- Citations by year
- 2024: 2 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 5 · 2015: 7 · 2014: 14 · 2013: 8 · 2012: 10
- FWCI
- 9.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- exercise intensity, running surface, hemolysis, inflammation, hepcidin, interleukin-6, free hemoglobin, haptoglobin, iron, ferritin, endurance athletes, interval running
- MeSH terms
- Anti-Bacterial Agents, Exercise Test, Physical Exertion, Hemolysis, Humans, Male, Oxygen Consumption, Running, Surface Properties, Cytokines, Antimicrobial Cationic Peptides, Young Adult, Hepcidins
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