Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity
Abstract
The effect of two running sessions completed within a 12-h period on hemolysis, inflammation, and hepcidin activity in endurance athletes was investigated. Ten males completed two experimental trials in a randomized, counterbalanced order. The two trials included (a) a one-running-session trial (T1) including 10 x 1 km interval repeats (90% peak VO2 velocity), and (b) a two-running-session trial (T2), comprising a continuous 10-km run (70% peak VO2 velocity), and a 10 x 1 km interval run (90% peak VO2 velocity) completed 12 h later. Interleukin-6 (IL-6), free hemoglobin (Hb), haptoglobin (Hp), iron, ferritin, and hepcidin were assessed post-exercise. After the T1 and T2 interval runs, free Hb was significantly increased and Hp significantly decreased (p <or= 0.05), with a cumulative effect shown in T2 after the second run (p <or= 0.05). The IL-6, serum iron, ferritin, and hepcidin activity were increased after each running session (p <or= 0.05), with no cumulative effect in T2. In conclusion, a cumulative effect of two running sessions on hemolysis was shown, but no similar effect with inflammation and hepcidin activity was evident.
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These prevalence rates are linked to sex differences, poor dietary intake, exercise-induced iron losses, and menstrual cycle perturbations of iron regulation.
“These prevalence rates are linked to sex differences [317], poor dietary intake, exercise-induced iron losses, and menstrual cycle perturbations of iron regulation [38,318,319].”
From International society of sports nutrition position stand: nutritional concerns of the female athlete (2023) · cites this paper as [318]
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- Authors
- Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E. T., Swinkels, D. W., & Trinder, D.
- Affiliations
- The University of Western Australia (AU)
- Radboud University Nijmegen (NL)
- Corresponding author
- Peeling, Peter
- Venue
- European Journal of Applied Physiology
- Published
- 2009-01-31
- Volume
- 106
- Issue
- 1
- Pages
- 51-59
- ISSN
- 0020-9376 (ISSN-L)
- 1439-6319
- 1439-6327
- OpenAlex
- W2167193833
- Cited by
- 95
- References
- 32
- Citations by year
- 2024: 1 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 7 · 2014: 15 · 2013: 6 · 2012: 7
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- European Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- exercise-induced hemolysis, free hemoglobin, haptoglobin, interleukin-6, inflammation, hepcidin, iron metabolism, ferritin, endurance athletes, interval running, continuous operation
- MeSH terms
- Adult, Exercise Test, Physical Exertion, Ferritins, Haptoglobins, Hemoglobins, Hemolysis, Humans, Inflammation, Iron, Male, Running, Time Factors, Interleukin-6, Cross-Over Studies, Antimicrobial Cationic Peptides, Hepcidins
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