Cited by 95Exercise and Physiological ResponsesIron Metabolism and DisordersCardiovascular and exercise physiology

Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity

Peeling, Peter, Dawson, Brian, Goodman, Carmel, Landers, Grant, Wiegerinck, Erwin T., Swinkels, Dorine W., Trinder, Debbie·2009·European Journal of Applied Physiology

Abstract

The effect of two running sessions completed within a 12-h period on hemolysis, inflammation, and hepcidin activity in endurance athletes was investigated. Ten males completed two experimental trials in a randomized, counterbalanced order. The two trials included (a) a one-running-session trial (T1) including 10 x 1 km interval repeats (90% peak VO2 velocity), and (b) a two-running-session trial (T2), comprising a continuous 10-km run (70% peak VO2 velocity), and a 10 x 1 km interval run (90% peak VO2 velocity) completed 12 h later. Interleukin-6 (IL-6), free hemoglobin (Hb), haptoglobin (Hp), iron, ferritin, and hepcidin were assessed post-exercise. After the T1 and T2 interval runs, free Hb was significantly increased and Hp significantly decreased (p <or= 0.05), with a cumulative effect shown in T2 after the second run (p <or= 0.05). The IL-6, serum iron, ferritin, and hepcidin activity were increased after each running session (p <or= 0.05), with no cumulative effect in T2. In conclusion, a cumulative effect of two running sessions on hemolysis was shown, but no similar effect with inflammation and hepcidin activity was evident.

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Crossref · 10.1007/s00421-009-0988-7

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  • These prevalence rates are linked to sex differences, poor dietary intake, exercise-induced iron losses, and menstrual cycle perturbations of iron regulation.

    “These prevalence rates are linked to sex differences [317], poor dietary intake, exercise-induced iron losses, and menstrual cycle perturbations of iron regulation [38,318,319].”

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Authors
Peeling, P., Dawson, B., Goodman, C., Landers, G., Wiegerinck, E. T., Swinkels, D. W., & Trinder, D.
Affiliations
  • The University of Western Australia (AU)
  • Radboud University Nijmegen (NL)
Corresponding author
Peeling, Peter
Venue
European Journal of Applied Physiology
Published
2009-01-31
Volume
106
Issue
1
Pages
51-59
ISSN
  • 0020-9376 (ISSN-L)
  • 1439-6319
  • 1439-6327
OpenAlex
W2167193833
Cited by
95
References
32
Citations by year
2024: 1 · 2023: 6 · 2022: 4 · 2021: 3 · 2020: 4 · 2019: 7 · 2018: 9 · 2017: 3 · 2016: 6 · 2015: 7 · 2014: 15 · 2013: 6 · 2012: 7
FWCI
8.15
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • UWA Profiles and Research Repository (UWA) (submittedVersion)
  • Radboud Repository (Radboud University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords
exercise-induced hemolysis, free hemoglobin, haptoglobin, interleukin-6, inflammation, hepcidin, iron metabolism, ferritin, endurance athletes, interval running, continuous operation
MeSH terms
Adult, Exercise Test, Physical Exertion, Ferritins, Haptoglobins, Hemoglobins, Hemolysis, Humans, Inflammation, Iron, Male, Running, Time Factors, Interleukin-6, Cross-Over Studies, Antimicrobial Cationic Peptides, Hepcidins

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