Peak Oxygen Uptake and Cardiovascular Risk Factors in 4631 Healthy Women and Men
Abstract
INTRODUCTION: Many studies suggest that cardiorespiratory fitness, measured as peak oxygen uptake (VO2peak), may be the single best predictor of cardiovascular morbidity and premature cardiovascular mortality. However, current reference values are either estimates of oxygen uptake or come from small studies, mainly of men. Therefore, the aims of this study were to directly measure VO2peak in healthy adult men and women and to assess the association with cardiovascular risk factor levels. METHODS: A cross-sectional study of 4631 volunteering, free-living Norwegian men (n = 2368) and women (n = 2263) age 20-90 yr. The data collection was from June 2007 to June 2008. Participants were free from known pulmonary or cardiovascular disease. VO2peak was measured by ergospirometry during treadmill running. Associations (odds ratios, OR) with unfavorable levels of cardiovascular risk factors and a cluster of cardiovascular risk factors were assessed by logistic regression analysis. RESULTS: Overall, mean VO2peak was 40.0 ± 9.5 mL·kg(-1)·min(-1). Women below the median VO2peak (<35.1 mL·kg(-1)·min(-1)) were five times (OR = 5.4, 95% confidence interval = 2.3-12.9) and men below the median (<44.2 mL·kg(-1)·min(-1)) were eight times (OR = 7.9, 95% confidence interval = 3.5-18.0) more likely to have a cluster of cardiovascular risk factors compared to those in the highest quartile of VO2peak (≥40.8 and ≥50.5 mL·kg(-1)·min(-1) in women and men, respectively). Each 5-mL·kg(-1)·min(-1) lower VO2peak corresponded to ∼56% higher odds of cardiovascular risk factor clustering. CONCLUSIONS: These data represent the largest reference material of objectively measured VO2peak in healthy men and women age 20-90 yr. Even in people considered to be fit, VO2peak was clearly associated with levels of conventional cardiovascular risk factors.
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Based on longitudinal and cross-sectional studies, an age dependent decline in peak oxygen uptake of at least 3.5 mL/kg/min over the five year period was expected.
“Based on longitudinal35 36 and cross sectional studies,37 we expected an age dependent decline in peak oxygen uptake of at least 3.5 mL/kg/min over the five year period.”
From Effect of exercise training for five years on all cause mortality in older adults—the Generation 100 study: randomised controlled trial (2020) · cites this paper as [37]
Cites
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
2007 Guidelines for the Management of Arterial Hypertension
Mancia, G., Backer, G. D., Dominiczak, A. F., Cífková, R., Fagard, R. H., Germanò, G., Grassi, G. M., Heagerty, A. M., Kjeldsen, S. E., Laurent, S., et al. (2007) · Journal of Hypertension · doi:10.1097/hjh.0b013e3281fc975a · Cited by 5,818 · see citing works
Exercise capacity and mortality among men referred for exercise testing
Myers, J., Prakash, M., Froelicher, V., Do, D., Partington, S., & Atwood, J. E. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa011858 · Cited by 4,114 · see citing works
Physical Fitness and All-Cause Mortality: A Prospective Study of Healthy Men and Women
Blair, S. N. (1989) · JAMA · doi:10.1001/jama.1989.03430170057028 · Cited by 2,658 · see citing works
Blair, S. N. (1995) · JAMA · doi:10.1001/jama.273.14.1093 · Cited by 2,088 · see citing works
Aerobic work capacity in men and women with special reference to age.
Åstrand, I. (1960) · PubMed · Cited by 1,586 · see citing works
Tjønna, A. E., Lee, S. J., Rognmo, Ø., Stølen, T. O., Bye, A., Haram, P. M., Loennechen, J. P., Al-Share, Q. Y., Skogvoll, E., Slørdahl, S. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.108.772822 · Cited by 1,145 · see citing works
Self-citationAccelerated longitudinal decline of aerobic capacity in healthy older adults
Fleg, J. L., Morrell, C. H., Bos, A. G., Brant, L. J., Talbot, L. A., Wright, J. G., & Lakatta, E. G. (2005) · Circulation · doi:10.1161/circulationaha.105.545459 · Cited by 970 · see citing works
Lakka, T. A., Venalainen, J. M., Rauramaa, R., Salonen, R., Tuomilehto, J., & Salonen, J. T. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406023302201 · Cited by 793 · see citing works
Physical Fitness as a Predictor of Mortality among Healthy, Middle-Aged Norwegian Men
Sandvik, L., Erikssen, J., Thaulow, E., Erikssen, G., Mundal, R., & Rodahl, K. (1993) · New England Journal of Medicine · doi:10.1056/nejm199302253280803 · Cited by 788 · see citing works
Rognmo, Ø., Hetland, E. V., Helgerud, J., Hoff, J., & Slørdahl, S. A. (2004) · European Journal of Cardiovascular Prevention & Rehabilitation · doi:10.1097/01.hjr.0000131677.96762.0c · Cited by 707 · see citing works
Experimental studies of physical fitness in relation to age
Robinson, S. (1938) · European Journal of Applied Physiology · doi:10.1007/bf02011412 · Cited by 672 · see citing works
The Nord-Trøndelag Health Study 1995-97 (HUNT 2): Objectives, contents, methods and participation
Holmen, J., Midthjell, K., Krüger, Ø., Langhammer, A., Holmen, T. L., Bratberg, G. H., Vatten, L., & Lund‐Larsen, P. G. (2003) · Cited by 526 · see citing works
Self-citationSedentary Lifestyle, Poor Cardiorespiratory Fitness, and the Metabolic Syndrome
Lakka, T. A., Laaksonen, D. E., Lakka, H.-M., NNIKK, N. M., NISKANEN, L. K., Rauramaa, R., & Salonen, J. T. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000079076.74931.9a · Cited by 472 · see citing works
Changes in physical fitness and changes in mortality
Erikssen, G., Liestøl, K., Bjørnholt, J., Thaulow, E., Sandvik, L., & Erikssen, J. (1998) · The Lancet · doi:10.1016/s0140-6736(98)02268-5 · Cited by 464 · see citing works
Aerobic fitness norms for males and females aged 6 to 75 years: a review.
Shvartz, E., & Rc, R. (1990) · PubMed · Cited by 449 · see citing works
Lee, D.-C., Sui, X., Ortega, F. B., Kim, Y.-S., Church, T. S., Winett, R. A., Ekelund, U., Katzmarzyk, P. T., & Blair, S. N. (2010) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.066209 · Cited by 435 · see citing works
Peak aerobic capacity predicts prognosis in patients with coronary heart disease
Keteyian, S. J., Brawner, C. A., Savage, P. D., Ehrman, J. K., Schairer, J. R., Divine, G., Aldred, H. A., Ophaug, K. M., & Ades, P. A. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.03.017 · Cited by 416 · see citing works
Rustad, P., Felding, P., Franzson, L., Kairisto, V., Lahti, A., Mårtensson, A., Petersen, P. H., Simonsson, P., Steensland, H., & Uldall, A. (2004) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.1080/00365510410006324 · Cited by 404 · see citing works
Changes in Physical Fitness and Changes in Mortality
&NA; (1999) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-199903000-00010 · Cited by 384 · see citing works
Longitudinal variations in maximal oxygen intake with age and activity.
Dehn, M. M., & Bruce, R. A. (1972) · Journal of Applied Physiology · doi:10.1152/jappl.1972.33.6.805 · Cited by 341 · see citing works
Kurtze, N., Rangul, V., Hustvedt, B., & Flanders, W. D. (2008) · Scandinavian Journal of Public Health · doi:10.1177/1403494807085373 · Cited by 330 · see citing works
Role of Lifestyle and Aging on the Longitudinal Change in Cardiorespiratory Fitness
Jackson, A. S., Sui, X., Hébert, J. R., Church, T. S., & Blair, S. N. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.312 · Cited by 329 · cited 2× · see citing works
“This observation may translate into extended longevity, as well as extended independent living and improved quality of life (15,17).”
BackgroundLaukkanen, J. A., Kurl, S., Salonen, R. M., Rauramaa, R., & Salonen, J. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.06.013 · Cited by 282 · see citing works
MYERS, J. N., Gullestad, L. L., Vagelos, R. H., Do, D., Bellin, D., Ross, H. J., & Fowler, M. B. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-129-4-199808150-00004 · Cited by 269 · see citing works
Waist Circumference and Mortality
Koster, A., Leitzmann, M. F., Schatzkin, A. G., Mouw, T., Adams, K. F., van Eijk, J. T. M., Hollenbeck, A. R., & Harris, T. B. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwn079 · Cited by 227 · see citing works
Normal cardiopulmonary responses during incremental exercise in 20??? to 70-yr-old men
Inbar, O., Oren, A., Scheinowitz, M., Rotstein, A., Dlin, R. A., & Casaburi, R. H. (1994) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-199405000-00003 · Cited by 226 · see citing works
Talbot, L. A., Metter, E. J., & Fleg, J. L. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200002000-00024 · Cited by 189 · see citing works
CRESPO, C. J., AINSWORTH, B. E., KETEYIAN, S. J., HEATH, G. W., & SMIT, E. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199912000-00019 · Cited by 186 · see citing works
Cardiorespiratory Fitness and the Risk for Stroke in Men
Kurl, S., Laukkanen, J. A., Rauramaa, R., Lakka, T. A., Sivenius, J., & Salonen, J. T. (2003) · Archives of Internal Medicine · doi:10.1001/archinte.163.14.1682 · Cited by 162 · see citing works
Physical Fitness and Subsequent Myocardial Infarction in Healthy Workers
Peters, R. K. (1983) · JAMA · doi:10.1001/jama.1983.03330460034028 · Cited by 160 · see citing works
Laukkanen, J. A., Laaksonen, D. E., Lakka, T. A., Savonen, K. P., Rauramaa, R., Mäkikallio, T. H., & Kurl, S. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.01.371 · Cited by 127 · see citing works
Physical fitness and clustering of risk factors associated with the metabolic syndrome
WHALEY, M. H., Kampert, J. B., Kohl, H. W., & Blair, S. N. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199902000-00013 · Cited by 124 · see citing works
Tager, I. B., Hollenberg, M., & Satariano, W. A. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009382 · Cited by 84 · see citing works
Finley, C. E., LaMonte, M. J., Waslien, C., Barlow, C. E., Blair, S. N., & Nichaman, M. Z. (2006) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2006.02.012 · Cited by 74 · see citing works
Cardiorespiratory Fitness as a Feature of Metabolic Syndrome in Older Men and Women
Hassinen, M., Lakka, T. A., Savonen, K. P., Litmanen, H., Kiviaho, L., Laaksonen, D. E., Komulainen, P., & Rauramaa, R. (2008) · Diabetes Care · doi:10.2337/dc07-2298 · Cited by 71 · see citing works
Variations in Maximal Oxygen Intake with Physical Activity in Middle-Aged Men
McDonough, J. R., Kusumi, F., & Bruce, R. A. (1970) · Circulation · doi:10.1161/01.cir.41.5.743 · Cited by 64 · see citing works
Position statement: Testing physical condition in a population – how good are the methods?
Jørgensen, T., Andersen, L. B., Froberg, K., Maeder, U., Smith, L. V. H., & Aadahl, M. (2009) · European Journal of Sport Science · doi:10.1080/17461390902862664 · Cited by 42 · see citing works
Mácek, M., Seliger, V., Vávra, J., Skranc, O., Horák, J., Piric, M., Handzo, P., Rous, J., & Jirka, Z. (1979) · PubMed · Cited by 11 · see citing works
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Ross, R., Blair, S. N., Arena, R., Church, T. S., Després, J.-P., Franklin, B. A., Haskell, W. L., Kaminsky, L. A., Levine, B. D., Lavie, C. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000461 · Cited by 2,486 · see citing works
Self-citationSong, D., Yu, D. S. F., Li, P. W. C., & Lei, Y. (2018) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2018.01.002 · Cited by 244 · see citing works
Estimating V˙O2peak from a Nonexercise Prediction Model: The HUNT Study, Norway
NES, B. M., JANSZKY, I., VATTEN, L. J., NILSEN, T. I. L., ASPENES, S. T., & WISLØFF, U. (2011) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31821d3f6f · Cited by 219 · see citing works
Aerobic Capacity Reference Data in 3816 Healthy Men and Women 20–90 Years
Loe, H., Rognmo, Ø., Saltin, B., & Wisløff, U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064319 · Cited by 216 · see citing works
Self-citationTarp, J., Støle, A. P., Blond, K., & Grøntved, A. (2019) · Diabetologia · doi:10.1007/s00125-019-4867-4 · Cited by 173 · see citing works
Stensvold, D., Viken, H., Steinshamn, S. L., Dalen, H., Støylen, A., Loennechen, J. P., Reitlo, L. S., Zisko, N., Bækkerud, F. H., Tari, A. R., et al. (2020) · BMJ · doi:10.1136/bmj.m3485 · Cited by 154 · see citing works
Self-citationA simple nonexercise model of cardiorespiratory fitness predicts long-term mortality
NES, B. M., VATTEN, L. J., NAUMAN, J., JANSZKY, I., & WISLØFF, U. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000219 · Cited by 154 · see citing works
Self-citationNes, B. M., Gutvik, C. R., Lavie, C. J., Nauman, J., & Wisløff, U. (2017) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.09.031 · Cited by 108 · see citing works
Self-citationTari, A. R., Nauman, J., Zisko, N., Skjellegrind, H. K., Bosnes, I., Bergh, S., Stensvold, D., Selbæk, G., & Wisløff, U. (2019) · The Lancet Public Health · doi:10.1016/s2468-2667(19)30183-5 · Cited by 100 · see citing works
Self-citationStrand, L. B., Laugsand, L. E., Wisløff, U., Nes, B. M., Vatten, L., & Janszky, I. (2013) · SLEEP · doi:10.5665/sleep.2310 · Cited by 79 · see citing works
Self-citationStensvold, D., Viken, H., Rognmo, Ø., Skogvoll, E., Steinshamn, S., Vatten, L. J., Coombes, J. S., Anderssen, S. A., Magnussen, J., Ingebrigtsen, J. E., et al. (2015) · BMJ Open · doi:10.1136/bmjopen-2014-007519 · Cited by 70 · see citing works
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STENSVOLD, D., BUCHER SANDBAKK, S., VIKEN, H., ZISKO, N., REITLO, L. S., NAUMAN, J., GAUSTAD, S. E., HASSEL, E., MOUFACK, M., BRØNSTAD, E., et al. (2017) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001343 · Cited by 46 · see citing works
Self-citation
- Authors
- ASPENES, S. T., NILSEN, T. I. L., SKAUG, E.-A., BERTHEUSSEN, G. F., ELLINGSEN, Ø., VATTEN, L., & WISLØFF, U.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Venue
- Medicine & Science in Sports & Exercise
- Published
- 2011-08
- Volume
- 43
- Issue
- 8
- Pages
- 1465-1473
- ISSN
- 0195-9131 (ISSN-L)
- OpenAlex
- W2056825073
- Cited by
- 278
- References
- 39
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 13 · 2023: 25 · 2022: 12 · 2021: 25 · 2020: 24 · 2019: 29 · 2018: 20 · 2017: 18 · 2016: 17 · 2015: 22 · 2014: 25 · 2013: 13 · 2012: 16
- FWCI
- 49.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medicine & Science in Sports & Exercise (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Keywords
- peak oxygen uptake, cardiorespiratory fitness, cardiovascular risk factors, healthy adults, sex differences, cardiovascular mortality prediction
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Cross-Sectional Studies, Exercise Test, Female, Humans, Male, Middle Aged, Norway, Oxygen Consumption, Risk Factors, Young Adult
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