Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS)

Oikawa, Shinichi; Yokoyama, Mitsuhiro; Origasa, Hideki; Matsuzaki, Masunori; Matsuzawa, Yuji; Saito, Yasushi; Ishikawa, Yuichi; Sasaki, Jun; Hishida, Hitoshi; Itakura, Hiroshige; Kita, Toru; Kitabatake, Akira; Nakaya, Noriaki; Sakata, Toshiie; Shimada, Kazuyuki; Shirato, Kunio

doi:10.1016/j.atherosclerosis.2009.03.029

Cited by 125Fatty Acid Research and HealthLipoproteins and Cardiovascular HealthParaoxonase enzyme and polymorphisms

Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS)

Oikawa, Shinichi, Yokoyama, Mitsuhiro, Origasa, Hideki, Matsuzaki, Masunori, Matsuzawa, Yuji, Saito, Yasushi, Ishikawa, Yuichi, Sasaki, Jun +8 more·2009·Atherosclerosis

DOI 10.1016/j.atherosclerosis.2009.03.029

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Abstract

Background JELIS was a large-scale clinical trial that investigated the effects of eicosapentaenoic acid (EPA) on coronary artery disease (CAD). In this paper, the data of patients registered in JELIS were analysed to compare the incidence of CAD between patients with impaired glucose metabolism (IGM) and normoglycemic (NG) patients. The effect of EPA on the incidence of CAD in patients with IGM was also assessed.Methods The 18,645 hypercholesterolemic patients registered in JELIS were divided into two groups. One group consisted of patients with IGM (n=4565), which included the patients who had diabetes mellitus and patients who had a fasting plasma glucose of 110mg/dL or higher, either at the time of registration or after 6 months. The other group consisted of NG patients (n=14,080). CAD incidence of the two groups over the average 4.6-year follow-up period was compared, and the effect of EPA was assessed.Results Compared to NG patients, IGM patients had a significantly higher CAD hazard ratio (1.71 in the non-EPA group and 1.63 in the EPA group). The treatment with EPA resulted in a 22% decrease in the CAD incidence (P=0.048) in IGM patients and an 18% decrease (P=0.062) in NG patients.Conclusions It was found that the CAD risk in IGM patients is higher than in NG patients, and that highly purified EPA is very effective in decreasing the incidence of CAD among Japanese IGM patients, even though the intake of fish is high.

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The FIELD study reported that fibrates decrease CAD events in primary prevention.
“In contrast, it was reported in the FIELD study that fibrates decrease CAD events in primary prevention805).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [805]

Diabetes and cardiovascular disease. The Framingham study
Kannel, W. B. (1979) · JAMA · doi:10.1001/jama.241.19.2035 · Cited by 3,958 · see citing works
Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial
(1999) · The Lancet · doi:10.1016/s0140-6736(99)07072-5 · Cited by 3,812 · see citing works
Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., Oikawa, S., Sasaki, J., Hishida, H., Itakura, H., et al. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60527-3 · Cited by 2,516 · see citing works
Self-citation
Untitled work
(1999) · PubMed · Cited by 2,062 · see citing works
Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23)
Turner, R. C., Millns, H., Neil, H. A. W., Stratton, I. M., Manley, S. E., Matthews, D. R., & Holman, R. R. (1998) · BMJ · doi:10.1136/bmj.316.7134.823 · Cited by 2,014 · see citing works
Cholesterol Lowering With Simvastatin Improves Prognosis of Diabetic Patients With Coronary Heart Disease: A subgroup analysis of the Scandinavian Simvastatin Survival Study (4S)
Pyörälä, K., Pedersen, T. R., Kjekshus, J., Faergeman, O., Olsson, A. G., Thorgeirsson, G., & The Scandinavian Simvastatin Survival Study (4S) Group (1997) · Diabetes Care · doi:10.2337/diacare.20.4.614 · Cited by 1,623 · see citing works
Diabetes and cardiovascular disease
Howard, B. V., & Magee, M. F. (2000) · Current Atherosclerosis Reports · doi:10.1007/s11883-000-0046-8 · Cited by 1,386 · see citing works
Fish and Omega-3 Fatty Acid Intake and Risk of Coronary Heart Disease in Women
Hu, F. B. (2002) · JAMA · doi:10.1001/jama.287.14.1815 · Cited by 1,018 · see citing works
Cardiovascular Events and Their Reduction With Pravastatin in Diabetic and Glucose-Intolerant Myocardial Infarction Survivors With Average Cholesterol Levels: Subgroup Analyses in the Cholesterol And Recurrent Events (CARE) Trial
Goldberg, R. B., Mellies, M. J., Sacks, F. M., Moyé, L. A., Howard, B. V., Howard, W. J., Davis, B. R., Cole, T. G., Pfeffer, M. A., & Braunwald, E. (1998) · Circulation · doi:10.1161/01.cir.98.23.2513 · Cited by 986 · see citing works
Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
Arita, M., Bianchini, F., Aliberti, J., Sher, A., Chiang, N., Hong, S., Yang, R., Petasis, N. A., & Serhan, C. N. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042031 · Cited by 926 · see citing works
Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: A randomised controlled trial
Thies, F., Garry, J. M., Yaqoob, P., Rerkasem, K., Williams, J., Shearman, C. P., Gallagher, P. J., Calder, P. C., & Grimble, R. F. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12468-3 · Cited by 739 · see citing works
Intake of Fish and n3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese: The Japan Public Health Center-Based (JPHC) Study Cohort I
Iso, H., Kobayashi, M., Ishihara, J., Sasaki, S., Okada, K., Kita, Y., Kokubo, Y., & Tsugane, S. (2006) · Circulation · doi:10.1161/circulationaha.105.581355 · Cited by 557 · see citing works
Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression
Sekiya, M., Yahagi, N., Matsuzaka, T., Najima, Y., Nakakuki, M., Nagai, R., Ishibashi, S., Osuga, J.-I., Yamada, N., & Shimano, H. (2003) · Hepatology · doi:10.1016/j.hep.2003.09.028 · Cited by 415 · see citing works
Cardiac Benefits of Fish Consumption May Depend on the Type of Fish Meal Consumed
Mozaffarian, D., Lemaître, R. N., Kuller, L. H., Burke, G. L., Tracy, R. P., & Siscovick, D. S. (2003) · Circulation · doi:10.1161/01.cir.0000055315.79177.16 · Cited by 390 · see citing works
A Crucial Role of Sterol Regulatory Element-binding Protein-1 in the Regulation of Lipogenic Gene Expression by Polyunsaturated Fatty Acids
Yahagi, N., Shimano, H., Hasty, A. H., Amemiya-Kudo, M., Okazaki, H., Tamura, Y., Iizuka, Y., Shionoiri, F., Ohashi, K., Osuga, J.-I., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.50.35840 · Cited by 364 · see citing works
Secondary Prevention of Cardiovascular Events With Long-Term Pravastatin in Patients With Diabetes or Impaired Fasting Glucose
Keech, A., Colquhoun, D., Best, J., Kirby, A., Simes, R. J., Hunt, D., Hague, W., Beller, E., Arulchelvam, M., Baker, J., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.10.2713 · Cited by 313 · see citing works
Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia: Primary Prevention Cohort Study of the Japan Lipid Intervention Trial (J-LIT)
Matsuzaki, M., Kita, T., Mabuchi, H., Matsuzawa, Y., Nakaya, N., Oikawa, S., Saito, Y., Sasaki, J., Shimamoto, K., Itakura, H., et al. (2002) · Circulation Journal · doi:10.1253/circj.66.1087 · Cited by 260 · cited 2× · see citing works
“emia, a decrease in LDL-C led to a reduction in their CAD risk [2–8].”
BackgroundSelf-citation
Diabetes and Cardiovascular Disease in a Prospective Population Survey in Japan: The Hisayama Study
Fujishima, M., Kiyohara, Y., Kato, I., Ohmura, T., Iwamoto, H., Nakayama, K., Ohmori, S., & Yoshitake, T. (1996) · Diabetes · doi:10.2337/diab.45.3.s14 · Cited by 258 · see citing works
Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes
Mita, T., Watada, H., Ogihara, T., Nomiyama, T., Ogawa, O., Kinoshita, J., Shimizu, T., Hirose, T., Tanaka, Y., & Kawamori, R. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.03.005 · Cited by 145 · see citing works
Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS). Additional perspectives on tolerability of long-term treatment with lovastatin
Downs, J. R., Clearfield, M., Tyroler, H. A., Whitney, E. J., Kruyer, W., Langendorfer, A., Zagrebelsky, V., Weis, S., Shapiro, D. R., Beere, P. A., et al. (2001) · The American Journal of Cardiology · doi:10.1016/s0002-9149(01)01464-3 · Cited by 138 · see citing works
Purified Eicosapentaenoic Acid Reduces Small Dense LDL, Remnant Lipoprotein Particles, and C-Reactive Protein in Metabolic Syndrome
Satoh, N., Shimatsu, A., Kotani, K., Sakane, N., Yamada, K., Suganami, T., Kuzuya, H., & Ogawa, Y. (2006) · Diabetes Care · doi:10.2337/dc06-1179 · Cited by 137 · see citing works
n-3 Fatty Acids in the Treatment of Diabetic Patients
Caterina, R. D., Madonna, R., Bertolotto, A., & Schmidt, E. B. (2007) · Diabetes Care · doi:10.2337/dc06-1332 · Cited by 135 · see citing works
Large Scale Cohort Study of the Relationship Between Serum Cholesterol Concentration and Coronary Events With Low-Dose Simvastatin Therapy in Japanese Patients With Hypercholesterolemia and Coronary Heart Disease: Secondary Prevention Cohort Study of the Japan Lipid Intervention Trial (J-LIT)
Mabuchi, H., Kita, T., Matsuzaki, M., Matsuzawa, Y., Nakaya, N., Oikawa, S., Saito, Y., Sasaki, J., Shimamoto, K., Itakura, H., et al. (2002) · Circulation Journal · doi:10.1253/circj.66.1096 · Cited by 132 · see citing works
Self-citation
Effects of eicosapentaenoic acid on cardiovascular events in Japanese patients with hypercholesterolemia: rationale, design, and baseline characteristics of the Japan EPA Lipid Intervention Study (JELIS)
Yokoyama, M., & Origasa, H. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00367-3 · Cited by 117 · see citing works
Self-citation
The effects of the oral administration of fish oil concentrate on the release and the metabolism of [14C]arachidonic acid and [14C]eicosapentaenoic acid by human platelets
Hirai, A., Terano, T., Hamazaki, T., Sajiki, J., Kondo, S., Ozawa, A., Fujita, T., Miyamoto, T., Tamura, Y., & Kumagai, A. (1982) · Thrombosis Research · doi:10.1016/0049-3848(82)90112-8 · Cited by 114 · see citing works
Effect of orally administered eicosapentaenoic acid (EPA) on the formation of leukotriene B4 and leukotriene B5 by rat leukocytes
Terano, T., Salmon, J. A., & Moncada, S. (1984) · Biochemical Pharmacology · doi:10.1016/0006-2952(84)90611-7 · Cited by 105 · see citing works
Fish oil fatty acids and human platelets: Dose-dependent decrease in dienoic and increase in trienoic thromboxane generation
Kramer, H. J., Stevens, J., Grimminger, F., & Seeger, W. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00473-x · Cited by 76 · see citing works
Eicosapentaenoic acid suppressed the proliferation of vascular smooth muscle cells through modulation of various steps of growth signals
Terano, T., Shiina, T., & Tamura, Y. (1996) · Lipids · doi:10.1007/bf02637096 · Cited by 62 · see citing works
Risk of coronary events in Japanese patients with both hypercholesterolemia and type 2 diabetes mellitus on low-dose simvastatin therapy: Implication from Japan Lipid Intervention Trial (J-LIT)
Oikawa, S., Kita, T., Mabuchi, H., Matsuzaki, M., Matsuzawa, Y., Nakaya, N., Saito, Y., Sasaki, J., Shimamoto, K., & Itakura, H. (2007) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.04.017 · Cited by 33 · see citing works
Self-citation
Changes in Aspects Such as the Collagenous Fiber Density and Foam Cell Size of Atherosclerotic Lesions Composed of Foam Cells, Smooth Muscle Cells and Fibrous Components in Rabbits Caused by All-cis-5, 8, 11, 14, 17-icosapentaenoic Acid.
Kawano, H., Yano, T., Mizuguchi, K., Mochizuki, H., & Saitō, Y. (2002) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.9.170 · Cited by 16 · see citing works

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Swanson, D., Block, R., & Mousa, S. A. (2012) · Advances in Nutrition · doi:10.3945/an.111.000893 · Cited by 1,575 · see citing works
Clinical Practice Guidelines for Multiple Endocrine Neoplasia Type 1 (MEN1)
Thakker, R. V., Newey, P. J., Walls, G. V., Bilezikian, J. P., Dralle, H., Ebeling, P. R., Melmed, S. K., Sakurai, A., Tonelli, F., & Brandi, M. L. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1230 · Cited by 1,473 · see citing works
Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer
Francis, G. L., Waguespack, S. G., Bauer, A. J., Angelos, P., Benvenga, S., Cerutti, J. M., Dinauer, C., Hamilton, J. K., HAY, I. D., Luster, M., et al. (2015) · Thyroid · doi:10.1089/thy.2014.0460 · Cited by 1,253 · see citing works
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Consensus Statement By The American Association Of Clinical Endocrinologists And American College Of Endocrinology On The Comprehensive Type 2 Diabetes Management Algorithm – 2016 EXECUTIVE SUMMARY
Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S. E., DeFronzo, R. A., EINHORN, D. F., Fonseca, V. A., et al. (2016) · Endocrine Practice · doi:10.4158/ep151126.cs · Cited by 874 · see citing works
Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017
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Consensus statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the comprehensive type 2 diabetes management algorithm—2019 executive summary.
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Sawada, T., Tsubata, H., Hashimoto, N., Takabe, M., Miyata, T., Aoki, K., Yamashita, S., Oishi, S., Osue, T., Yokoi, K., et al. (2016) · Cardiovascular Diabetology · doi:10.1186/s12933-016-0437-y · Cited by 97 · see citing works
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Venturini, D., Simão, A. N. C., Urbano, M. R., & Dichi, I. (2015) · Nutrition · doi:10.1016/j.nut.2014.12.016 · Cited by 95 · see citing works
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Mas, E., Woodman, R. J., Burke, V., Puddey, I. B., Beilin, L. J., Durand, T., & Mori, T. A. (2010) · Free Radical Research · doi:10.3109/10715762.2010.492830 · Cited by 95 · see citing works
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Zaima, N., Sasaki, T., Tanaka, H., Cheng, X. W., Onoue, K., Hayasaka, T., Goto‐Inoue, N., Enomoto, H., Unno, N., Kuzuya, M., et al. (2011) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.03.044 · Cited by 81 · see citing works
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Fish Oil for Primary and Secondary Prevention of Coronary Heart Disease
Roth, E. M., & Harris, W. S. (2009) · Current Atherosclerosis Reports · doi:10.1007/s11883-009-0079-6 · Cited by 74 · see citing works
Effects of icosapent ethyl on lipid and inflammatory parameters in patients with diabetes mellitus-2, residual elevated triglycerides (200–500 mg/dL), and on statin therapy at LDL-C goal: the ANCHOR study
Brinton, E. A., Ballantyne, C. M., Bays, H. E., Kastelein, J. J., Braeckman, R. A., & Soni, P. N. (2013) · Cardiovascular Diabetology · doi:10.1186/1475-2840-12-100 · Cited by 70 · see citing works
Dietary fats and mortality among patients with type 2 diabetes: analysis in two population based cohort studies
Jiao, J., Liu, G., Shin, H. J., Hu, F. B., Rimm, E. B., Rexrode, K. M., Manson, J. E., Zong, G., & Sun, Q. (2019) · BMJ · doi:10.1136/bmj.l4009 · Cited by 69 · see citing works
Omega-3 Fatty Acids in Atherosclerosis and Coronary Artery Disease
Bäck, M. (2017) · Future Science OA · doi:10.4155/fsoa-2017-0067 · Cited by 69 · see citing works
Fatty Acid Metabolism in Carriers of Apolipoprotein E Epsilon 4 Allele: Is It Contributing to Higher Risk of Cognitive Decline and Coronary Heart Disease?
Chouinard‐Watkins, R., & Plourde, M. (2014) · Nutrients · doi:10.3390/nu6104452 · Cited by 67 · see citing works
Effects of n‐3 pufas on fasting plasma glucose and insulin resistance in patients with impaired fasting glucose or impaired glucose tolerance
Derosa, G., Cicero, A. F. G., D’Angelo, A., Borghi, C., & Maffioli, P. (2016) · BioFactors · doi:10.1002/biof.1277 · Cited by 65 · see citing works
Do patients benefit from omega-3 fatty acids?
Sherratt, S. C. R., Mason, R. P., Libby, P., Steg, P. G., & Bhatt, D. L. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad188 · Cited by 71 · see citing works
Omega‐3 production by fermentation of Yarrowia lipolytica: From fed‐batch to continuous
Xie, D., Miller, E., Sharpe, P. L., Jackson, E. N., & Zhu, Q. (2016) · Biotechnology and Bioengineering · doi:10.1002/bit.26216 · Cited by 64 · see citing works
Dietary and Pharmacological Fatty Acids and Cardiovascular Health
Wu, H., Xu, L., & Ballantyne, C. M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz174 · Cited by 59 · see citing works
EPA, not DHA, prevents fibrosis in pressure overload-induced heart failure: potential role of free fatty acid receptor 4
Eclov, J. A., Qian, Q., Redetzke, R. A., Chen, Q., Wu, S. C., Healy, C. L., Ortmeier, S. B., Harmon, E. B., Shearer, G. C., & O’Connell, T. D. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m062034 · Cited by 57 · see citing works
Fish Oil Derived Omega 3 Fatty Acids Suppress Adipose NLRP3 Inflammasome Signaling in Human Obesity
Roberts-Lee, K., Midgette, Y. A., & Shah, R. D. (2018) · Journal of the Endocrine Society · doi:10.1210/js.2018-00220 · Cited by 57 · see citing works
Cardiovascular Diseases, Depression Disorders and Potential Effects of Omega-3 Fatty Acids
Trebatická, J., Dukát, A., Ďuračková, Z., & Muchová, J. (2017) · Physiological Research · doi:10.33549/physiolres.933430 · Cited by 55 · see citing works
Consensus Statement by the American Association of Clinical Endocrinologists and American College of Endocrinology on the Comprehensive Type 2 Diabetes Management Algorithm - 2015 Executive Summary
Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S. E., Davidson, M., EINHORN, D. F., Garber, J. R., et al. (2015) · Endocrine Practice · doi:10.4158/ep151063.cs · Cited by 55 · see citing works
Omega-6 and omega-3 fatty acids: partners in prevention
Harris, W. S. (2010) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283357242 · Cited by 49 · see citing works
Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease
Li, S., Wang, J., Yang, Y., Liu, Z., Cheng, L. Z., Liu, H.-Y., Ma, P., Luo, W. H., & Liu, S. (2016) · Journal of Translational Medicine · doi:10.1186/s12967-016-0834-8 · Cited by 48 · see citing works
JCS 2023 Guideline on the Primary Prevention of Coronary Artery Disease
Fujiyoshi, A., Kohsaka, S., Hata, J., Hara, M., Kai, H., Masuda, D., Miyamatsu, N., Nishio, Y., Ogura, M., Sata, M., et al. (2024) · Circulation Journal · doi:10.1253/circj.cj-23-0285 · Cited by 47 · see citing works
Stearidonic Acid–Enhanced Soybean Oil: A Plant-Based Source of (n-3) Fatty Acids for Foods
Harris, W. S. (2012) · Journal of Nutrition · doi:10.3945/jn.111.146613 · Cited by 45 · see citing works
Two methods provide similar signals for the need to update systematic reviews
Chung, M. C., Newberry, S. J., Ansari, M. T., Yu, W. W., Wu, H., Lee, J., Suttorp, M. J., Gaylor, J. M., Motala, A., Moher, D., et al. (2012) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2011.12.004 · Cited by 42 · see citing works
The role of omega-3 polyunsaturated fatty acid supplementation in the management of type 2 diabetes mellitus: A narrative review
Itsiopoulos, C., Marx, W., Mayr, H. L., Tatucu-Babet, O. A., Dash, S. R., George, E. S., Trakman, G. L., Kelly, J. T., Thomas, C. J., & Brazionis, L. (2018) · Journal of Nutrition & Intermediary Metabolism · doi:10.1016/j.jnim.2018.02.002 · Cited by 37 · see citing works
Plasma fatty acids and the risk of vascular disease and mortality outcomes in individuals with type 2 diabetes: results from the ADVANCE study
Harris, K., Oshima, M., Sattar, N. A., Würtz, P., Jun, M., Welsh, P. I., Hamet, P., Harrap, S. B., Poulter, N. R., Chalmers, J. P., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05162-z · Cited by 36 · see citing works
Therapies for diabetic dyslipidaemia
Bell, D. S. H., Badarin, F. J. A., & O’Keefe, J. H. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01342.x · Cited by 36 · see citing works
History and future of omega-3 fatty acids in cardiovascular disease
Sperling, L. S., & Nelson, J. R. (2016) · Current Medical Research and Opinion · doi:10.1185/03007995.2015.1120190 · Cited by 34 · see citing works
Functional Lipids and Cardiovascular Disease Reduction: A Concise Review
Omachi, D. O., Aryee, A. N. A., & Onuh, J. O. (2024) · Nutrients · doi:10.3390/nu16152453 · Cited by 36 · see citing works
Administration of highly purified eicosapentaenoic acid to statin-treated diabetic patients further improves vascular function
Sasaki, J., Miwa, T., & Odawara, M. (2012) · Endocrine Journal · doi:10.1507/endocrj.ej11-0394 · Cited by 31 · see citing works
Self-citation
Diabetic dyslipidaemia
Thambiah, S. C., & Lai, L. C. (2021) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2021.e00248 · Cited by 33 · see citing works
Kinetics of eicosapentaenoic acid in brain, heart and liver of conscious rats fed a high n-3 PUFA containing diet
Igarashi, M., Chang, L., Ma, K., & Rapoport, S. (2013) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2013.09.004 · Cited by 28 · see citing works
Integrating diet and exercise into care of prostate cancer patients on androgen deprivation therapy
Moyad, M. A., Newton, R. U., Tunn, U. W., & Gruca, D. (2016) · Research and Reports in Urology · doi:10.2147/rru.s107852 · Cited by 29 · see citing works
Effects of Extra‐Virgin Olive Oil and Fish Oil on Lipid Profile and Oxidative Stress in Patients with Metabolic Syndrome
Dichi, I., Venturini, D., Urbano, M. R., & Simão, A. N. C. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.595.2 · Cited by 24 · see citing works
Fish oils, coronary heart disease, and the environment
Greene, J., Ashburn, S. M., Razzouk, L., & Smith, D. A. (2013) · American Journal of Public Health · doi:10.2105/ajph.2012.300959 · Cited by 23 · see citing works
Prevention and Intervention Trials for Colorectal Cancer
Komiya, M., Fujii, G., Takahashi, M., Iigo, M., & Mutoh, M. (2013) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyt053 · Cited by 23 · see citing works
Prescription omega-3 fatty acid products: Considerations for patients with diabetes mellitus
Avallone, L., Shaikh, A., Hassan, A., & Tajuddin, N. (2016) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s97036 · Cited by 22 · see citing works
Marine-derived n-3 fatty acids therapy for stroke
Campano, C. G. A., MacLeod, M. J., Thiès, F., Aucott, L. S., & Macleod, M. R. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012815 · Cited by 22 · see citing works
Understanding why REDUCE-IT was positive – Mechanistic overview of eicosapentaenoic acid
Harris, W. S. (2019) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2019.10.008 · Cited by 21 · see citing works
The limited effect of omega-3 polyunsaturated fatty acids on cardiovascular risk in patients with impaired glucose metabolism: A meta-analysis
Zheng, T., Zhao, J., Wang, Y., Liu, W., Wang, Z., Shang, Y., Zhang, W., Zhang, Y., & Zhong, M. (2013) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2013.11.025 · Cited by 21 · see citing works
Fish consumption is associated with a decreased risk of death among adults with diabetes: 18-year follow-up of a national cohort
Deng, A., Pattanaik, S., Bhattacharya, A., Yin, J., Ross, L., Liu, C., & Zhang, J. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.05.011 · Cited by 19 · see citing works
Vascepa protects against high-fat diet-induced glucose intolerance, insulin resistance, and impaired β-cell function
Rijjal, D. A., Liu, Y., Lai, M., Song, Y., Danaei, Z., Wu, A., Mohan, H., Li, W., Schopfer, F. J., Dai, F. F., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102909 · Cited by 19 · see citing works
Association between the docosahexaenoic acid to arachidonic acid ratio and acute coronary syndrome: a multicenter observational study
Nishizaki, Y., Shimada, K., Tani, S., Ogawa, T., Ando, J., Takahashi, M., Yamamoto, M., Shinozaki, T., Miyazaki, T., Miyauchi, K., et al. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-016-0299-y · Cited by 19 · see citing works
Self-citation
Diabetes Mellitus
Teramoto, T., Sasaki, J., Ishibashi, S., Birou, S., Daida, H., Dohi, S., Egusa, G., Hiro, T., Hirobe, K., Iida, M., et al. (2013) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.19349 · Cited by 18 · see citing works
Self-citation
Suyun Biyokimyası ve Fonksiyonları
Akbağ, H. I. (2024) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.3266.c9392 · Cited by 14 · see citing works
Lipid effects of icosapent ethyl in women with diabetes mellitus and persistent high triglycerides on statin treatment: ANCHOR trial subanalysis
Brinton, E. A., Ballantyne, C. M., Guyton, J. R., Philip, S., Doyle, R. T., Juliano, R. A., & Mosca, L. (2018) · Journal of Women's Health · doi:10.1089/jwh.2017.6757 · Cited by 13 · see citing works
Low serum docosahexaenoic acid is associated with progression of coronary atherosclerosis in statin-treated patients with diabetes mellitus: results of the treatment with statin on atheroma regression evaluated by intravascular ultrasound with virtual histology (TRUTH) study
Nozue, T., Yamamoto, S., Tohyama, S., Fukui, K., Umezawa, S., Onishi, Y., Kunishima, T., Sato, A., Nozato, T., Miyake, S., et al. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-13 · Cited by 13 · see citing works
Fish Oil Selectively Improves Heart Function in a Mouse Model of Lipid-induced Cardiomyopathy
Khan, R. S., Chokshi, A. D., Drosatos, K., Jiang, H., Yu, S., Harris, C. R., Schulze, P. C., Homma, S., Blaner, W. S., Shulman, G. I., et al. (2013) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318283d845 · Cited by 12 · see citing works
Pemafibrate, a PPAR alpha agonist, attenuates neointima formation after vascular injury in mice fed normal chow and a high-fat diet
Horikawa, T., Kawanami, T., Hamaguchi, Y., Tanaka, Y., Kita, S., Ryorin, R., Takashi, Y., Takahashi, H., Tanabe, M., Yanase, T., et al. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05431 · Cited by 12 · see citing works
High long-chain n-3 fatty acid intake attenuates the effect of high resting heart rate on cardiovascular mortality risk: A 24-year follow-up of Japanese general population
Hisamatsu, T., Miura, K., Ohkubo, T., Yamamoto, T., Fujiyoshi, A., Miyagawa, N., Kadota, A., Takashima, N., Okuda, N., Yoshita, K., et al. (2014) · Journal of Cardiology · doi:10.1016/j.jjcc.2014.01.005 · Cited by 11 · see citing works
Diabetes and the Cardiovascular System
McGuire, D. K. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-0398-6.00064-0 · Cited by 11 · see citing works
Dyslipidemia in Chronic Kidney Disease
Streja, E., & Streja, D. A. (2022) · doi:10.1002/9781119105954.ch34 · Cited by 11 · see citing works
A new pure ω-3 eicosapentaenoic acid ethyl ester (AMR101) for the management of hypertriglyceridemia: the MARINE trial
Jacobson, T. A. (2012) · Expert Review of Cardiovascular Therapy · doi:10.1586/erc.12.56 · Cited by 9 · see citing works
Synergistic Effect of Eicosapentaenoic Acid on Antiproliferative Action of Anticancer Drugs in a Cancer Cell Line Model
Ogo, A., Miyake, S., Kubota, H., Higashida, M., Matsumoto, H., Teramoto, F., & Hirai, T. (2017) · Annals of Nutrition and Metabolism · doi:10.1159/000484618 · Cited by 9 · see citing works
Documento de consenso de la Sociedad Española de Arteriosclerosis (SEA) para la prevención y tratamiento de la enfermedad cardiovascular en la diabetes mellitus tipo 2
Ruiz‐García, A., Arranz-Martínez, E., Merchante, I. M., Fuster, V. P., Tamarit, J. J., Trias, F., Pintó, X., & Ascaso, J. F. (2018) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2018.06.006 · Cited by 9 · see citing works
Triglyceride/high density lipoprotein cholesterol index and future cardiovascular events in diabetic patients without known cardiovascular disease
Nakashima, R., Ikeda, S., Shinohara, K., Matsumoto, S., Yoshida, D., Ono, Y., Nakashima, H., Miyamoto, R., Matsushima, S., Kishimoto, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-92933-6 · Cited by 8 · see citing works
Promoting Wellness for Patients on Androgen Deprivation Therapy: Why Using Numerous Drugs for Drug Side Effects Should Not Be First-Line Treatment
Moyad, M. A., & Roach, M. (2011) · Urologic Clinics of North America · doi:10.1016/j.ucl.2011.05.001 · Cited by 8 · see citing works
Marine-derived n-3 fatty acids therapy for stroke
Campano, C. G. A., MacLeod, M. J., Aucott, L. S., & Thiès, F. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012815.pub2 · Cited by 9 · see citing works
Current Understanding of Diabetic Dyslipidemia: A Review
Gupta, A., & Gupta, R. (2022) · Journal of the Indian Institute of Science · doi:10.1007/s41745-022-00346-5 · Cited by 6 · see citing works
Association of Fish Oil Supplementation with Risk of Coronary Heart Disease in Individuals with Diabetes and Prediabetes: A Prospective Study in the UK Biobank
Liu, X., Li, Y., Wan, X., Zhuang, P., Wu, Y., Zhang, L., Yang, A., Yao, J., Zhang, Y., & Jiao, J. (2023) · Nutrients · doi:10.3390/nu15143176 · Cited by 7 · see citing works
Marine-derived n-3 fatty acids therapy for stroke
Campano, C. G. A., MacLeod, M. J., Aucott, L. S., & Thiès, F. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012815.pub3 · Cited by 6 · see citing works
A meta-analytic evaluation of cholesteryl ester transfer protein (CETP) C-629A polymorphism in association with coronary heart disease risk and lipid changes
Lin, S., Dai, R., & Lin, R. (2016) · Oncotarget · doi:10.18632/oncotarget.12898 · Cited by 6 · see citing works
Polyunsaturated fatty acids in cardiovascular diseases: uncertainty prevails
Siniarski, A., & Gajos, G. (2021) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.16066 · Cited by 6 · see citing works
Long-chain omega-3 fatty acids and cardiovascular health
Kuratko, C. N., Nolan, C., & Salem, N. (2014) · Nutrafoods · doi:10.1007/s13749-014-0020-7 · Cited by 5 · see citing works
Japan EPA Lipid Intervention Study (JELIS). Randomized clinical trial involving primary and secondary prevention of cardiovascular events with EPA in hypercholesterolemia
Yokoyama, M. (2009) · Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics · doi:10.3143/geriatrics.46.22 · Cited by 4 · see citing works
Self-citation
Impact of eicosapentaenoic acid/arachidonic acid ratio on left ventricular structure in patients with diabetes
Okamoto, K., Sato, A., MATSUKAWA, K., Kasuga, T., & Uchigata, Y. (2014) · Diabetology International · doi:10.1007/s13340-014-0172-0 · Cited by 4 · see citing works
Omega-3 Fatty Acids in Prevention of Cardiovascular Disease in Humans
Sharma, R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-396485-4.00028-1 · Cited by 4 · see citing works
Chemical and physical parameters supporting the top-rated product of Kapi-pla, a gastronomy of southern food, Thailand
Siripongvutikorn, S., Pumethakul, K., thantrirat, J., Sirinupong, N., Chansuwan, W., Usawakesmanee, W., & Rujirapong, C. (2025) · Journal of Agriculture and Food Research · doi:10.1016/j.jafr.2025.101856 · Cited by 3 · see citing works
The Mechanism of the Synergistic Anticancer Effect of CDDP and EPA in the TE1 Cell Line
Ogo, A., Miyake, S., Kubota, H., Higashida, M., Matsumoto, H., Teramoto, F., Hirai, T., & Ueno, T. (2021) · Anticancer Research · doi:10.21873/anticanres.14942 · Cited by 3 · see citing works

Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS)
Saito, Y., Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Ishikawa, Y., Oikawa, S., Sasaki, J., Hishida, H., Itakura, H., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.06.003 · Cited by 316 · see citing works
Self-citation
Effects of eicosapentaenoic acid on cardiovascular events in Japanese patients with hypercholesterolemia: rationale, design, and baseline characteristics of the Japan EPA Lipid Intervention Study (JELIS)
Yokoyama, M., & Origasa, H. (2003) · American Heart Journal · doi:10.1016/s0002-8703(03)00367-3 · Cited by 117 · see citing works
Self-citation
4 Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors : Sub-analysis of primary prevention cases from JELIS(Late Breaking Clinical Trials I,Special Program,The 72nd Annual Scientific Meeting of the Japanese Circulation Society)
Ishikawa, Y., Matsuzaki, M., Origasa, H., Matsuzawa, Y., Saitō, Y., Yokoyama, M., Oikawa, S., Sasaki, J., Hishida, H., Itakura, H., et al. (2008) · Japanese Circulation Journal-english Edition
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Relationship between Coronary Artery Disease and Non-HDL-C, and Effect of Highly Purified EPA on the Risk of Coronary Artery Disease in Hypercholesterolemic Patients Treated with Statins: Sub-Analysis of the Japan EPA Lipid Intervention Study (JELIS)
Sasaki, J., Yokoyama, M., Matsuzaki, M., Saito, Y., Origasa, H., Ishikawa, Y., Oikawa, S., Itakura, H., Hishida, H., Kita, T., et al. (2012) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.8326 · Cited by 35 · see citing works
Self-citation
Relationships between plasma fatty acid composition and coronary artery disease.
Itakura, H., Yokoyama, M., Matsuzaki, M., Saito, Y., Origasa, H., Ishikawa, Y., Oikawa, S., Sasaki, J., Hishida, H., Kita, T., et al. (2011) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.5876 · Cited by 218 · see citing works
Self-citation

Authors: Oikawa, S., Yokoyama, M., Origasa, H., Matsuzaki, M., Matsuzawa, Y., Saito, Y., Ishikawa, Y., Sasaki, J., Hishida, H., Itakura, H., Kita, T., Kitabatake, A., Nakaya, N., Sakata, T., Shimada, K., & Shirato, K.
Affiliations: Nippon Medical School (JP)
Hyogo Prefectural Awaji Medical Center (JP)
University of Toyama (JP)
Yamaguchi University (JP)
Kobe University (JP)
Fujita Health University (JP)
Ibaraki Christian University (JP)
Kyoto University (JP)
Nakamura Gakuen University (JP)
Jichi Medical University (JP)
Corresponding author: Oikawa, Shinichi
ORCID: Oikawa, Shinichi
Origasa, Hideki
Ishikawa, Yuichi
Shimada, Kazuyuki
Venue: Atherosclerosis
Publisher: Elsevier BV
Published: 2009-10
Volume: 206
Issue: 2
Pages: 535-539
ISSN: 0021-9150 (ISSN-L)
DOI: 10.1016/j.atherosclerosis.2009.03.029
OpenAlex: W2007616354
Cited by: 125
References: 30
Citations by year: 2026: 1 · 2025: 2 · 2024: 11 · 2023: 7 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 14 · 2017: 7 · 2016: 11 · 2015: 8 · 2014: 7 · 2013: 12 · 2012: 12
FWCI: 7.42
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Atherosclerosis (publishedVersion)
PubMed (publishedVersion)
Funders: Mochida Pharmaceutical Company
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords: eicosapentaenoic acid, coronary artery disease, impaired glucose metabolism, hypercholesterolemia, diabetes mellitus, omega-3 fatty acids, cardiovascular risk reduction, fasting blood glucose
MeSH terms: Adult, Aged, Coronary Artery Disease, Diabetes Mellitus, Female, Humans, Hypercholesterolemia, Japan, Male, Middle Aged, Eicosapentaenoic Acid, Hydroxymethylglutaryl-CoA Reductase Inhibitors

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Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS)

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