Gender Difference in Coronary Events in Relation to Risk Factors in Japanese Hypercholesterolemic Patients Treated With Low-Dose Simvastatin
Open accessAbstract
BACKGROUND: Gender differences between the risk factors for coronary heart disease and coronary events were examined in the Japan Lipid Intervention Trial, a 6-year observational study. METHODS AND RESULTS: Men (12,575) and women (27,013) were analyzed for risk of coronary events (acute myocardial infarction and sudden cardiac death). Simvastatin reduced serum low-density lipoprotein cholesterol (LDL-C) by 27% in both genders, and increased serum high-density lipoprotein cholesterol (HDL-C) in men (5%) and women (4%). The incidence of coronary events was lower in women (0.64/1,000 patient-years) than in men (1.57/1,000 patient-years). The risk of coronary events increased by 18% in men and 21% in women with each 10 mg/dl elevation of LDL-C, and decreased by 39% in men and 33% in women with each 10 mg/dl elevation of HDL-C. The risk increased proportionally with aging in women, but not in men. Diabetes mellitus (DM) was more strongly related to the risk of coronary events for women (relative risk 3.07) than for men (relative risk 1.58). CONCLUSIONS: The incidence of coronary events is lower in women. Serum LDL-C is related to an increased risk of coronary events to the same extent in both genders. DM seems to be a more important risk factor in women, trading off the lower risk of coronary events among them.
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Among all deaths from cerebrovascular and cardiovascular causes, subjects with grade-I hypertension made up the highest proportion.
“Among all deaths from these causes, subjects with grade-I hypertension made up the highest proportion123).”
From Japan Atherosclerosis Society (JAS) guidelines for prevention of atherosclerotic cardiovascular diseases 2017 (2018) · cites this paper as [123]
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Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423 · see citing works
Yusuf, S., Hawken, S., Ôunpuu, S., Dans, T., Avezum, A., Lanas, F., McQueen, M., Budaj, A., Pais, P., Varigos, J., et al. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17018-9 · Cited by 12,026 · see citing works
D'Agostino, R. B., Grundy, S., Sullivan, L. M., Wilson, P., & for the CHD Risk Prediction Group (2001) · JAMA · doi:10.1001/jama.286.2.180 · Cited by 2,108 · see citing works
Alcohol consumption and mortality among middle-aged and elderly U.S. adults
Thun, M. J., Peto, R., Lopez, A. D., Monaco, J. H., Henley, S. J., Heath, C. W., & Doll, R. (1997) · New England Journal of Medicine · doi:10.1056/nejm199712113372401 · Cited by 1,313 · see citing works
Neaton, J. D. (1992) · Archives of Internal Medicine · doi:10.1001/archinte.1992.00400130082009 · Cited by 784 · see citing works
Sex Differences in Coronary Heart Disease
Barrett-Connor, E. L. (1997) · Circulation · doi:10.1161/01.cir.95.1.252 · Cited by 648 · see citing works
Lee, W. L., Cheung, A. M., Cape, D., & Zinman, B. (2000) · Diabetes Care · doi:10.2337/diacare.23.7.962 · Cited by 442 · see citing works
Gender Difference in the Impact of Type 2 Diabetes on Coronary Heart Disease Risk
Juutilainen, A., Kortelainen, S., Lehto, S., Rönnemaa, T., Pyörälà, K., & Laakso, M. (2004) · Diabetes Care · doi:10.2337/diacare.27.12.2898 · Cited by 432 · see citing works
Smoking, Serum Lipids, Blood Pressure, and Sex Differences in Myocardial Infarction
Njølstad, I., Arnesen, E., & Lund‐Larsen, P. G. (1996) · Circulation · doi:10.1161/01.cir.93.3.450 · Cited by 406 · see citing works
The Primary Prevention of Coronary Heart Disease in Women
Rich-Edwards, J. W., Manson, J. E., Hennekens, C. H., & Buring, J. E. (1995) · New England Journal of Medicine · doi:10.1056/nejm199506293322607 · Cited by 382 · see citing works
Matsuzaki, M., Kita, T., Mabuchi, H., Matsuzawa, Y., Nakaya, N., Oikawa, S., Saito, Y., Sasaki, J., Shimamoto, K., Itakura, H., et al. (2002) · Circulation Journal · doi:10.1253/circj.66.1087 · Cited by 260 · see citing works
Self-citationWalden, C. E., Knopp, R. H., Wahl, P. W., Beach, K. W., & Strandness, E. (1984) · New England Journal of Medicine · doi:10.1056/nejm198410113111505 · Cited by 253 · see citing works
Cigarette Smoking as a Risk Factor for Stroke Death in Japan: NIPPON DATA80
Ueshima, H., Reza Choudhury, S., Okayama, A., Hayakawa, T., Kita, Y., Kadowaki, T., Okamura, T., Minowa, M., & Iimura, O. (2004) · Stroke · doi:10.1161/01.str.0000131747.84423.74 · Cited by 189 · see citing works
Asia Pacific Cohort Studies Collaboration (2005) · International Journal of Epidemiology · doi:10.1093/ije/dyi104 · Cited by 179 · see citing works
Mabuchi, H., Kita, T., Matsuzaki, M., Matsuzawa, Y., Nakaya, N., Oikawa, S., Saito, Y., Sasaki, J., Shimamoto, K., Itakura, H., et al. (2002) · Circulation Journal · doi:10.1253/circj.66.1096 · Cited by 132 · see citing works
Self-citationMatsuzawa, Y., Kita, T., Mabuchi, H., Matsuzaki, M., Nakaya, N., Oikawa, S., Saitō, Y., Sasaki, J., Shimamoto, K., Itakura, H., et al. (2003) · Circulation Journal · doi:10.1253/circj.67.287 · Cited by 80 · see citing works
Self-citationBasic models for disease occurrence in epidemiology.
Flanders, W., & Kleinbaum, D. (1995) · International Journal of Epidemiology · doi:10.1093/ije/24.1.1 · Cited by 57 · see citing works
Nakaya, N., Kita, T., Mabuchi, H., Matsuzaki, M., Matsuzawa, Y., Oikawa, S., Saitō, Y., Sasaki, J., Shimamoto, K., Itakura, H., et al. (2005) · Circulation Journal · doi:10.1253/circj.69.1016 · Cited by 44 · see citing works
Self-citation51321例の日本人高コレステロール血症患者を対象とした最小副作用での6年間の低容量シンバスタチン療法における血清コレステロールの持続的低下 大規模全国コホート試験J-LIT試験の意義
Matsuzawa, Y., Kita, T., Mabuchi, H., Matsuzaki, M., Nakaya, N., Oikawa, S., SAITO, Y., Sasaki, J., & Itakura, H. (2003) · Circulation · Cited by 42 · see citing works
Self-citationMatsuzawa, Y., Itakura, H., Kita, T., Mabuchi, H., Matsuzaki, M., Nakaya, N., Oikawa, S., Saitō, Y., Sasaki, J., & Shimamoto, K. (2000) · Current Therapeutic Research · doi:10.1016/s0011-393x(00)89037-2 · Cited by 16 · see citing works
Self-citationIwashita, M., Matsushita, Y., Sasaki, J., Arakawa, K., Kono, S., & for the Kyushu Lipid Intervention Study (KLIS) Group (2004) · Circulation Journal · doi:10.1253/circj.68.405 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Kinoshita, M., Yokote, K., Arai, H., Iida, M., Ishigaki, Y., Ishibashi, S., Umemoto, S., Egusa, G., Ohmura, H., Okamura, T., et al. (2018) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2017 · Cited by 813 · see citing works
Okamura, T., Tsukamoto, K., Arai, H., Fujioka, Y., Ishigaki, Y., Koba, S., Ohmura, H., Shoji, T., Yokote, K., Yoshida, H., et al. (2023) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.gl2022 · Cited by 317 · see citing works
Satoh, H., Saijo, Y., Yoshioka, E., & Tsutsui, H. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.5157 · Cited by 96 · see citing works
Sex/Gender Medicine The Biological Basis for Personalized Care in Cardiovascular Medicine
Arain, F. A., Kuniyoshi, F. H. S., Abdalrhim, A. D., & Miller, V. M. (2009) · Circulation Journal · doi:10.1253/circj.cj-09-0588 · Cited by 84 · see citing works
Vitvitsky, V., Prudova, A., Stabler, S. P., Dayal, S., Lentz, S. R., & Banerjee, R. V. (2007) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00171.2007 · Cited by 55 · see citing works
Tseng, C. (2007) · Circulation Journal · doi:10.1253/circj.71.1131 · Cited by 43 · see citing works
Dong, X., Cai, R., Sun, J. L., Huang, R., Pin, W., Sun, H., Tian, S., & Wang, S. (2017) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2887 · Cited by 41 · see citing works
Shimizu, M., Kanazawa, K., Hirata, K., Ishida, T., Hiraoka, E., Matsuda, Y., Iwai, C., Miyamoto, Y., Hashimoto, M., Kajiya, T., et al. (2007) · Circulation Journal · doi:10.1253/circj.71.842 · Cited by 39 · see citing works
Izawa, K. P., Oka, K., Watanabe, S., Yokoyama, H., Hiraki, K., Morio, Y., Kasahara, Y., & Omiya, K. (2008) · Acta Dermato Venereologica · doi:10.2340/16501977-0156 · Cited by 29 · see citing works
Unique Features of High-Density Lipoproteins in the Japanese: In Population and in Genetic Factors
Yokoyama, S. (2015) · Nutrients · doi:10.3390/nu7042359 · Cited by 28 · see citing works
Effect of Helicobacter pylori Infection on Serum Lipid Profile
Haeri, M., Parham, M., Habibi, N., & Vafaeimanesh, J. (2018) · Journal of Lipids · doi:10.1155/2018/6734809 · Cited by 26 · see citing works
Sex differences in nicotine dependency and depressive tendency among smokers
Komiyama, M., Yamakage, H., Satoh‐Asahara, N., Ozaki, Y., Morimoto, T., Shimatsu, A., Takahashi, Y., & Hasegawa, K. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.06.010 · Cited by 24 · see citing works
Satoh, H., Tomita, K., Fujii, S., Kishi, R., & Tsutsui, H. (2009) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.1644 · Cited by 18 · see citing works
Ishikawa, T., Mizuno, K., Nakaya, N., Ohashi, Y., Tajima, N., Kushiro, T., Teramoto, T., Uchiyama, S., Nakamura, H., & for the MEGA Study Group (2008) · Circulation Journal · doi:10.1253/circj.cj-08-0095 · Cited by 18 · see citing works
Self-citationTani, S., Takahashi, A., Nagao, K., & Hirayama, A. (2014) · Heart and Vessels · doi:10.1007/s00380-014-0554-z · Cited by 17 · see citing works
Saitō, Y., Kita, T., Mabuchi, H., Matsuzaki, M., Matsuzawa, Y., Nakaya, N., Oikawa, S., Sasaki, J., Shimamoto, K., & Itakura, H. (2010) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.2782 · Cited by 11 · see citing works
Self-citationGender differences in patients undergoing coronary stenting in current stent era.
Woo, M., Fan, C.-Q., Chen, Y., Hussein, H., Fang, H., Lin, C., & Wu, C. (2011) · PubMed · Cited by 8 · see citing works
Michishita, R. (2014) · Journal of Metabolic Syndrome · doi:10.4172/2167-0943.1000150 · Cited by 8 · see citing works
Yoshihisa, A., Iwai‐Takano, M., Yaoita, H., Watanabe, T., & Maruyama, Y. (2007) · Circulation Journal · doi:10.1253/circj.71.954 · Cited by 8 · see citing works
Gender Differences in Patients With Coronary Artery Disease in Japan
Kambara, H., Yamazaki, T., Hayashi, D., Kohro, T., Okada, Y., Nagai, R., & The JCAD Investigators (2009) · Circulation Journal · doi:10.1253/circj.cj-08-0252 · Cited by 8 · see citing works
Kosugi, T., Eriguchi, M., Yoshida, H., Tamaki, H., Uemura, T., Tasaki, H., Furuyama, R., Fukata, F., Nishimoto, M., Matsui, M., et al. (2024) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.65107 · Cited by 7 · see citing works
Inadera, H., & Hamazaki, T. (2010) · Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene) · doi:10.1265/jjh.65.506 · Cited by 4 · see citing works
The Biological Basis for Personalized Care in Cardiovascular Medicine
Arain, F. A., Kuniyoshi, F. H. S., Abdalrhim, A. D., & Miller, V. M. (2010) · Cited by 2 · see citing works
HDL Cholesterol Concentration may Become One of the Predictors for Future Renal Dysfunction in JAPAN
Komatsu, T., & Uehara, Y. (2024) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.ed276 · Cited by 1 · see citing works
Renovascular Hypertension and Related Conditions
Watanabe, T., & Fan, J. (2025) · Springer eBooks · doi:10.1007/978-981-96-3675-4_18 · Cited by 1 · see citing works
Gender Difference in High-density Lipoprotein Cholesterol in Japanese
Takahashi, E., Moriyama, K., & Yamada, C. (2012) · Ningen dock : official journal of the Japanese Society of Human Dry Dock · doi:10.11320/ningendock.27.108 · Cited by 1 · see citing works
Statins and Gender-Related Difference in Endothelial Function in Cerebral Small Vessel Disease
Tsuda, K. (2009) · Stroke · doi:10.1161/strokeaha.109.556696 · Cited by 1 · see citing works
Alhasan, M. A., & Salih, M. B. (2023) · University of Thi-Qar Journal of Science · doi:10.32792/utq/utjsci/v10i2.1073
Semaw, M., Megabiew, F., Walle, M., Woldesenbet, D., Tamir, M., Mekuanint, A., Yenesew, A., Cherie, N., Berta, D. M., Teketelew, B. B., et al. (2024) · Research Square · doi:10.21203/rs.3.rs-4292224/v1
Kojima, K., & Okumura, Y. (2025) · Hypertension Research · doi:10.1038/s41440-025-02477-5
メタボリックシンドロームにおけるHDLコレステロール値は性差を考慮しなくてよいか?(2.メタボリックシンドロームの診断基準はこのままでよいか?,<特集II>第72回日本循環器学会学術集会)
淳, 佐. (2009) · Journal of JCS Cardiologists · doi:10.1253/jjcsc.17.1_37
- Authors
- Sasaki, J., Kita, T., Mabuchi, H., Matsuzaki, M., Matsuzawa, Y., Nakaya, N., Oikawa, S., Saito, Y., Shimamoto, K., Kono, S., Itakura, H., & The J-LIT Study Group
- Affiliations
- International University of Health and Welfare Graduate School of Clinical Trial Management
- Kyoto University (JP)
- Kanazawa University (JP)
- Yamaguchi University (JP)
- Sumitomo Hospital
- Nakaya Clinic
- Nippon Medical School (JP)
- Chiba University Graduate School of Medicine
- Sapporo Medical University (JP)
- Kyushu University (JP)
- Ibaraki Christian University (JP)
- Venue
- Circulation Journal
- Publisher
- Japanese Circulation Society
- Published
- 2006
- Volume
- 70
- Issue
- 7
- Pages
- 810-814
- ISSN
- 1346-9843 (ISSN-L)
- 1347-4820
- OpenAlex
- W1996326128
- Cited by
- 32
- References
- 22
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 2 · 2018: 3 · 2017: 1 · 2015: 1 · 2014: 2 · 2012: 1
- FWCI
- 3.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Journal (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Kanazawa University Repository for Academic Resources (DSpace) (Kanazawa University) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
- Keywords
- sex differences, coronary artery disease, acute myocardial infarction, sudden cardiac death, simvastatin, hypercholesterolemia, LDL cholesterol, HDL cholesterol, diabetes mellitus, coronary risk factors, aging
- MeSH terms
- Adult, Age Factors, Aged, Anticholesteremic Agents, Coronary Disease, Death, Female, Humans, Hypercholesterolemia, Japan, Cholesterol, LDL, Male, Middle Aged, Myocardial Infarction, Predictive Value of Tests, Risk Factors, Sex Factors, Simvastatin, Asian People
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