Circadian Rhythms in the CNS and Peripheral Clock Disorders: Role of the Biological Clock in Cardiovascular Diseases
Open accessAbstract
The cardiovascular diseases are closely related to circadian rhythm, which is under the control of the biological clock. Clock genes show circadian oscillation not only in the suprachiasmatic nucleus but also in peripheral tissues, suggesting the existence of the peripheral clock. We previously demonstrated that plasminogen activator inhibitor-1 (PAI-1) might be an output gene of the peripheral clock. To further elucidate the functional relevance of the peripheral clock in the cardiovascular system, we screened target genes of the peripheral clock by cDNA microarray analysis. A total of 29 genes including transcription factor, growth factors, and membrane receptors were upregulated by CLOCK/BMAL and showed circadian oscillation. These results suggest that cardiovascular systems have their own peripheral clocks, and at least in part, they may regulate the circadian oscillation of cardiovascular function directly. These results potentially provide a molecular basis for the circadian variation of cardiovascular function and novel strategies for the prevention and treatment of cardiovascular diseases.
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Investigations into the cardiovascular system revealed diurnal variations in gene expression, protein expression, and organ function and a potential influence of both inter- and intra-organ circadian clock disruptions on the pathogenesis of the cardiometabolic syndrome.
“Investigations into the cardiovascular system revealed diurnal variations in gene expression, protein expression, and organ function 111 and a potential influence of both inter‐ and intra‐organ circadian clock disruptions on the pathogenesis of the cardiometabolic syndrome.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [111]
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- Authors
- Maemura, K., Takeda, N., & Nagai, R.
- Affiliations
- The University of Tokyo (JP)
- Venue
- Journal of Pharmacological Sciences
- Publisher
- Japanese Pharmacological Society
- Published
- 2007
- Volume
- 103
- Issue
- 2
- Pages
- 134-138
- ISSN
- 1347-8613 (ISSN-L)
- 1347-8648
- OpenAlex
- W2089878744
- Cited by
- 73
- References
- 29
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Pharmacological Sciences (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian rhythm, peripheral clocks, clock genes, cardiovascular disease, plasminogen activator inhibitor-1, suprachiasmatic nucleus, Clock/BMAL1, circadian oscillations, transcription factors, growth factors, cell surface receptors
- MeSH terms
- Animals, Biological Clocks, Cardiovascular Diseases, Central Nervous System, Circadian Rhythm, Humans
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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