The Molecular Clock and Neurodegenerative Disease: A Stressful Time
Open accessAbstract
Circadian rhythm dysfunction occurs in both common and rare neurodegenerative diseases. This dysfunction manifests as sleep cycle mistiming, alterations in body temperature rhythms, and an increase in symptomatology during the early evening hours known as Sundown Syndrome. Disruption of circadian rhythm homeostasis has also been implicated in the etiology of neurodegenerative disease. Indeed, individuals exposed to a shifting schedule of sleep and activity, such as health care workers, are at a higher risk. Thus, a bidirectional relationship exists between the circadian system and neurodegeneration. At the heart of this crosstalk is the molecular circadian clock, which functions to regulate circadian rhythm homeostasis. Over the past decade, this connection has become a focal point of investigation as the molecular clock offers an attractive target to combat both neurodegenerative disease pathogenesis and circadian rhythm dysfunction, and a pivotal role for neuroinflammation and stress has been established. This review summarizes the contributions of molecular clock dysfunction to neurodegenerative disease etiology, as well as the mechanisms by which neurodegenerative diseases affect the molecular clock.
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CLOCK, CRY, and BMAL1 can regulate secretion of cytokines and chemokines through many immune mediator genes.
“It has been reported that circadian locomotor output cycles protein kaput (CLOCK), cryptochrome (CRY) and brain and muscle ARNT-like protein 1 (BMAL1) can regulate the secretion of cytokines and chemokines through many immune mediator genes.121”
From Role of neuroinflammation in neurodegeneration development (2023) · cites this paper as [121]
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Alzheimer disease in the United States (2010–2050) estimated using the 2010 census
Hebert, L. E., Weuve, J., Scherr, P. A., & Evans, D. A. (2013) · Neurology · doi:10.1212/wnl.0b013e31828726f5 · Cited by 2,642 · cited 1× · see citing works
“In the United States alone, AD cases are projected to reach 14 million by 2050 (Hebert et al., 2013).”
BackgroundTranscriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,639 · see citing works
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421 · see citing works
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910 · see citing works
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449 · see citing works
Chang, A.-M., Aeschbach, D., Duffy, J. F., & Czeisler, C. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418490112 · Cited by 1,430 · see citing works
Molecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388 · see citing works
SIRT1 regulates circadian clock gene expression through PER2 deacetylation
Asher, G., Gatfield, D., Stratmann, M., Reinke, H., Dibner, C., Kreppel, F., Mostoslavsky, R., Alt, F. W., & Schibler, U. (2008) · Cell · doi:10.1016/j.cell.2008.06.050 · Cited by 1,376 · see citing works
Trinucleotide Repeat Disorders
Orr, H. T., & Zoghbi, H. Y. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113042 · Cited by 1,365 · see citing works
Synergy between amyloid-β and tau in Alzheimer’s disease
Busche, M. A., & Hyman, B. T. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0687-6 · Cited by 1,242 · see citing works
Bang, J., Spina, S., & Miller, B. L. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00461-4 · Cited by 1,144 · see citing works
Circadian control of the immune system
Scheiermann, C., Kunisaki, Y., & Frenette, P. S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3386 · Cited by 1,135 · see citing works
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
Menzies, F. M., Fleming, A., Caricasole, A., Bento, C. F., Andrews, S. P., Ashkenazi, A., Füllgrabe, J., Jackson, A., Jimenez Sanchez, M., Karabiyik, C., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.022 · Cited by 1,134 · see citing works
Disease-associated astrocytes in Alzheimer’s disease and aging
Habib, N., McCabe, C., Medina, S., Varshavsky, M., Kitsberg, D., Dvir-Szternfeld, R., Green, G., Dionne, D., Nguyen, L., Marshall, J. L., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0624-8 · Cited by 1,009 · see citing works
Luo, Y., Bolon, B., Kahn, S., Bennett, B. D., Babu-Khan, S., Denis, P., Fan, W., Kha, H., Zhang, J., Gong, Y., et al. (2001) · Nature Neuroscience · doi:10.1038/85059 · Cited by 1,001 · see citing works
Differential Functions of mPer1, mPer2, and mPer3 in the SCN Circadian Clock
Bae, K., Jin, X., Maywood, E. S., Hastings, M. H., Reppert, S. M., & Weaver, D. R. (2001) · Neuron · doi:10.1016/s0896-6273(01)00302-6 · Cited by 900 · see citing works
Mechanisms linking circadian clocks, sleep, and neurodegeneration
Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878 · see citing works
Compromised autophagy and neurodegenerative diseases
Menzies, F. M., Fleming, A., & Rubinsztein, D. C. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3961 · Cited by 851 · see citing works
The Role of Sirtuins in Antioxidant and Redox Signaling
Singh, C. K., Chhabra, G., Ndiaye, M. A., Garcia‐Peterson, L. M., Mack, N. J., & Ahmad, N. (2017) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7290 · Cited by 812 · see citing works
Oxidative stress response and Nrf2 signaling in aging
Zhang, H., Davies, K. J. A., & Forman, H. J. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.05.036 · Cited by 804 · see citing works
Oxidative stress in Alzheimer’s disease
Chen, Z., & Zhong, C. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1423-y · Cited by 797 · see citing works
Principles and Practice of Sleep Medicine
Kryger, M. H., Roth, T. G., & Dement, W. C. (2016) · Elsevier eBooks · doi:10.1016/c2012-0-03543-0 · Cited by 785 · see citing works
Rhythms of life: circadian disruption and brain disorders across the lifespan
Logan, R. W., & McClung, C. A. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0088-y · Cited by 713 · see citing works
Circadian control of brain glymphatic and lymphatic fluid flow
Hablitz, L. M., Plá, V., Giannetto, M., Vinitsky, H. S., Stæger, F. F., Metcalfe, T., Nguyen, R., Benrais, A., & Nedergaard, M. (2020) · Nature Communications · doi:10.1038/s41467-020-18115-2 · Cited by 704 · cited 1× · see citing works
“It is also important to note the proposed circadian rhythmicity observed in glymphatic influx and clearance in mice, where drainage and influx of CSF from the cisterna magna appear to be time-of-day dependent (Hablitz et al., 2020).”
BackgroundNeuroinflammation as a common feature of neurodegenerative disorders
Guzman-Martinez, L., Maccioni, R. B., Andrade, V., Navarrete, L. P., Pastor, M. G., & Ramos-Escobar, N. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01008 · Cited by 702 · see citing works
SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging
Chang, H.-C., & Guarente, L. (2013) · Cell · doi:10.1016/j.cell.2013.05.027 · Cited by 615 · see citing works
The redox chemistry of the Alzheimer's disease amyloid β peptide
Smith, D. G., Cappai, R., & Barnham, K. J. (2007) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.02.002 · Cited by 608 · see citing works
Walker, Z., Possin, K. L., Boeve, B. F., & Aarsland, D. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00462-6 · Cited by 605 · see citing works
Circadian patterns of gene expression in the human brain and disruption in major depressive disorder
Li, J. Z., Bunney, B. G., Meng, F., Hagenauer, M. H., Walsh, D. M., Vawter, M. P., Evans, S. J., Choudary, P. V., Cartagena, P., Barchas, J. D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1305814110 · Cited by 589 · see citing works
Metabolism and cancer: the circadian clock connection
Sahar, S., & Sassone-Corsi, P. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2747 · Cited by 551 · see citing works
González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 525 · see citing works
Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration
Musiek, E. S., Lim, M. M., Yang, G., Bauer, A. Q., Qi, L., Lee, Y., Roh, J. H., Ortiz-Gonzalez, X., Dearborn, J. T., Culver, J. P., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70317 · Cited by 524 · see citing works
Sleep and Circadian Rhythm Regulation in Early Parkinson Disease
Breen, D. P., Vuono, R., Nawarathna, U., Fisher, K., Shneerson, J. M., Reddy, A. B., & Barker, R. A. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.65 · Cited by 440 · see citing works
Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling
Brancaccio, M., Patton, A. P., Chesham, J. E., Maywood, E. S., & Hastings, M. H. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.030 · Cited by 437 · see citing works
The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective
Martini-Stoica, H., Xu, Y., Ballabio, A., & Zheng, H. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.02.002 · Cited by 436 · cited 1× · see citing works
“An additional PTM that is characterized by the acetylation of CLOCK and BMAL1 mediates gene expression by interacting with histone acetyltransferases (HATs) (Masri and Sassone-Corsi, 2010; Zhang and Sehgal, 2019).”
BackgroundMAPT mutations, tauopathy, and mechanisms of neurodegeneration
Strang, K. H., Golde, T. E., & Giasson, B. I. (2019) · Laboratory Investigation · doi:10.1038/s41374-019-0197-x · Cited by 424 · see citing works
Suofu, Y., Li, W., Jean‐Alphonse, F., Jia, J., Khattar, N. K., Li, J., Baranov, S. V., Leronni, D., Mihalik, A. C., He, Y., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1705768114 · Cited by 415 · see citing works
Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease
Morton, A. J., Wood, N. I., Hastings, M. H., Hurelbrink, C., Barker, R. A., & Maywood, E. S. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.3842-04.2005 · Cited by 403 · see citing works
Serio, A., Bilican, B., Barmada, S. J., Ando, D. M., Zhao, C., Siller, R., Burr, K., Haghi, G., Story, D., Nishimura, A. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300398110 · Cited by 345 · see citing works
A Drosophila model for age-associated changes in sleep:wake cycles
Koh, K., Evans, J. M., Hendricks, J. C., & Sehgal, A. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605903103 · Cited by 341 · see citing works
Circadian rhythms, time-restricted feeding, and healthy aging
Manoogian, E. N. C., & Panda, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.006 · Cited by 330 · see citing works
Spiller, K. J., Restrepo, C. R., Khan, T., Dominique, M. A., Fang, T. C., Canter, R. G., Roberts, C. J., Miller, K. R., Ransohoff, R. M., Trojanowski, J. Q., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0083-7 · Cited by 301 · see citing works
Aging and Alzheimer's disease: comparison and associations from molecular to system level
Xia, X., Jiang, Q., McDermott, J., & Han, J. J. (2018) · Aging Cell · doi:10.1111/acel.12802 · Cited by 301 · see citing works
Circadian Rhythms in Cyanobacteria
Cohen, S., & Golden, S. S. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-15 · Cited by 290 · see citing works
Han, K.-S., Kim, L., & Shim, I. (2012) · Experimental Neurobiology · doi:10.5607/en.2012.21.4.141 · Cited by 290 · see citing works
Skeletal muscle aging: influence of oxidative stress and physical exercise
Gomes, M. J., Martinez, P. F., Pagan, L. U., Damatto, R. L., Mariano Cezar, M. D., Ruiz Lima, A. R., Okoshi, K., & Okoshi, M. P. (2017) · Oncotarget · doi:10.18632/oncotarget.14670 · Cited by 285 · see citing works
The choreography of neuroinflammation in Huntington's disease
Crotti, A., & Glass, C. K. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.04.007 · Cited by 276 · see citing works
Pathologic Evaluation of the Human Suprachiasmatic Nucleus in Severe Dementia
Stopa, E. G., Volicer, L., Kuo-Leblanc, V., Harper, D., Lathi, D., Tate, B., & Satlin, A. (1999) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199901000-00004 · Cited by 265 · see citing works
Network Features of the Mammalian Circadian Clock
Baggs, J. E., Price, T. S., DiTacchio, L., Panda, S., FitzGerald, G. A., & Hogenesch, J. B. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000052 · Cited by 265 · see citing works
Circadian clock protein Rev-erbα regulates neuroinflammation
Griffin, P., Dimitry, J. M., Sheehan, P. W., Lananna, B. V., Guo, C., Robinette, M. L., Hayes, M. E., Cedeño, M. R., Nadarajah, C. J., Ezerskiy, L. A., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1812405116 · Cited by 263 · see citing works
Astrocytes Regulate Daily Rhythms in the Suprachiasmatic Nucleus and Behavior
Tso, C. F., Simon, T., Greenlaw, A. C., Puri, T. A., Mieda, M., & Herzog, E. D. (2017) · Current Biology · doi:10.1016/j.cub.2017.02.037 · Cited by 262 · see citing works
The Temperature Dependence of Sleep
Harding, E. C., Franks, N. P., & Wisden, W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00336 · Cited by 261 · cited 1× · see citing works
“This could be related to the lowering of core body temperature that occurs in healthy mammalian sleep cycles (Harding et al., 2019).”
BackgroundMecocci, P., Boccardi, V., Cecchetti, R., Bastiani, P., Scamosci, M., Ruggiero, C., & Baroni, M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170732 · Cited by 255 · see citing works
α-Synuclein Inhibits Intersynaptic Vesicle Mobility and Maintains Recycling-Pool Homeostasis
Scott, D. A., & Roy, S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0535-12.2012 · Cited by 243 · see citing works
Casein Kinase 1 Delta Regulates the Pace of the Mammalian Circadian Clock
Etchegaray, J., Machida, K., Noton, E., Constance, C. M., Dallmann, R., Napoli, M. N. D., DeBruyne, J. P., Lambert, C. M., Yu, E. A., Reppert, S. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00338-09 · Cited by 237 · see citing works
Garwood, C. J., Ratcliffe, L. E., Simpson, J. E., Heath, P. R., Ince, P. G., & Wharton, S. B. (2017) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12338 · Cited by 233 · see citing works
Advances in understanding the peripheral circadian clocks
Richards, J., & Gumz, M. L. (2012) · The FASEB Journal · doi:10.1096/fj.12-203554 · Cited by 233 · see citing works
The circadian clock ofNeurospora crassa
Baker, C. L., Loros, J., & Dunlap, J. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00288.x · Cited by 231 · see citing works
Jauhari, A., Baranov, S. V., Suofu, Y., Kim, J., Singh, T., Yablonska, S., Li, F., Wang, X., Oberly, P. J., Minnigh, M. B., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135026 · Cited by 215 · see citing works
Young, M. E. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00582.2005 · Cited by 212 · see citing works
A protein fold switch joins the circadian oscillator to clock output in cyanobacteria
Chang, Y.-G., Cohen, S. E., Phong, C., Myers, W. K., Kim, Y.-I., Tseng, R., Lin, J., Zhang, L., Boyd, J. S., Lee, Y., et al. (2015) · Science · doi:10.1126/science.1260031 · Cited by 212 · see citing works
Regulation of amyloid-β dynamics and pathology by the circadian clock
Kress, G. J., Liao, F., Dimitry, J. M., Cedeño, M. R., FitzGerald, G. A., Holtzman, D. M., & Musiek, E. S. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20172347 · Cited by 211 · see citing works
Lananna, B. V., McKee, C. A., King, M. W., Del-Aguila, J. L., Dimitry, J. M., Farias, F. H. G., Nadarajah, C. J., Xiong, D. D., Guo, C., Cammack, A. J., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax3519 · Cited by 201 · see citing works
Tauopathies as clinicopathological entities
Irwin, D. J. (2015) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2015.09.020 · Cited by 200 · see citing works
Regulation of human MAPT gene expression
Caillet‐Boudin, M., Buée, L., Sergeant, N., & Lefebvre, B. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0025-8 · Cited by 193 · see citing works
Pallier, P. N., Maywood, E. S., Zheng, Z., Chesham, J. E., Inyushkin, A. N., Dyball, R. E. J., Hastings, M. H., & Morton, A. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0649-07.2007 · Cited by 193 · see citing works
Singh, P., Hanson, P. S., & Morris, C. M. (2017) · BMC Neuroscience · doi:10.1186/s12868-017-0364-1 · Cited by 193 · see citing works
Circadian dysfunction in a mouse model of Parkinson's disease
Kudo, T., Loh, D. H., Truong, D., Wu, Y., & Colwell, C. S. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.08.003 · Cited by 188 · see citing works
Lee, H.-M., Chen, R., Kim, H., Etchegaray, J., Weaver, D. R., & Lee, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107178108 · Cited by 185 · see citing works
Making Time: Conservation of Biological Clocks from Fungi to Animals
Dunlap, J., & Loros, J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0039-2016 · Cited by 163 · see citing works
Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts
Fellner, L., Jellinger, K. A., Wenning, G. K., & Stefanova, N. (2011) · Acta Neuropathologica · doi:10.1007/s00401-011-0833-z · Cited by 162 · see citing works
Aging Alters Circadian and Light-Induced Expression of Clock Genes in Golden Hamsters
Kolker, D. E., Fukuyama, H., Huang, D. S., Takahashi, J. S., Horton, T. H., & Turek, F. W. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403251802 · Cited by 161 · see citing works
Casein Kinase 1 Delta Phosphorylates Tau and Disrupts Its Binding to Microtubules
Li, G., Yin, H., & Kuret, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314116200 · Cited by 159 · see citing works
Glial phagocytic clearance in Parkinson’s disease
Tremblay, M., Cookson, M., & Civiero, L. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0314-8 · Cited by 159 · see citing works
Prion-like transmission of neuronal huntingtin aggregates to phagocytic glia in the Drosophila brain
Pearce, M. M. P., Spartz, E. J., Hong, W., Luo, L., & Kopito, R. R. (2015) · Nature Communications · doi:10.1038/ncomms7768 · Cited by 159 · see citing works
Lee, J., Kim, D. E., Griffin, P. Y., Sheehan, P. W., Kim, D., Musiek, E. S., & Yoon, S. (2019) · Aging Cell · doi:10.1111/acel.13078 · Cited by 156 · see citing works
Aziz, N. A., Anguelova, G. V., Marinus, J., Lammers, G. J., & Roos, R. A. C. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.02.009 · Cited by 155 · see citing works
Aβ-induced degradation of BMAL1 and CBP leads to circadian rhythm disruption in Alzheimer’s disease
Song, H., Moon, M., Choe, H. K., Han, D.-H., Jang, C., Kim, A., Cho, S., Kim, K., & Mook‐Jung, I. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0007-x · Cited by 154 · see citing works
Circadian Clock Gene Bmal1 Is Not Essential; Functional Replacement with its Paralog, Bmal2
Shi, S.-Q., Hida, A., McGuinness, O. P., Wasserman, D. H., Yamazaki, S., & Johnson, C. H. (2010) · Current Biology · doi:10.1016/j.cub.2009.12.034 · Cited by 150 · see citing works
The circadian clock gene period extends healthspan in aging Drosophila melanogaster
Krishnan, N., Kretzschmar, D., Rakshit, K., Chow, E. S., & Giebultowicz, J. M. (2009) · Aging · doi:10.18632/aging.100103 · Cited by 148 · see citing works
Schwab, C., DeMaggio, A. J., Ghoshal, N., Binder, L. I., Kuret, J., & McGeer, P. L. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00110-x · Cited by 148 · see citing works
Circadian clock proteins control adaptation to novel environment and memory formation
Kondratova, A. A., Dubrovsky, Y. V., Antoch, M. P., & Kondratov, R. V. (2010) · Aging · doi:10.18632/aging.100142 · Cited by 147 · see citing works
The Suprachiasmatic Nucleus and the Circadian Timing System
Moore, R. Y. (2013) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396971-2.00001-4 · Cited by 146 · see citing works
Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 145 · see citing works
Cronin, P., McCarthy, M. J., Lim, A. S. P., Salmon, D. P., Galasko, D. R., Masliah, E., Jager, P. L. D., Bennett, D. A., & Desplats, P. (2016) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2016.10.003 · Cited by 140 · see citing works
Roscovitine-Derived, Dual-Specificity Inhibitors of Cyclin-Dependent Kinases and Casein Kinases 1
Oumata, N., Bettayeb, K., Ferandin, Y., Demange, L., Lopez-Giral, A., Goddard, M.-L., Myrianthopoulos, V., Mikros, E., Flajolet, M., Greengard, P., et al. (2008) · Journal of Medicinal Chemistry · doi:10.1021/jm800109e · Cited by 139 · see citing works
Roher, A. E., Garami, Z. F., Tyas, S. L., Maarouf, C. L., Kokjohn, T. A., Bëlohlávek, M., Vedders, L. J., Connor, D. J., Sabbagh, M. N., Beach, T. G., et al. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.09.002 · Cited by 138 · see citing works
Maywood, E. S., Fraenkel, E., McAllister, C., Wood, N. I., Reddy, A. B., Hastings, M. H., & Morton, A. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.1694-10.2010 · Cited by 135 · see citing works
A New Molecular Link between the Fibrillar and Granulovacuolar Lesions of Alzheimer's Disease
Ghoshal, N., Smiley, J. F., DeMaggio, A. J., Hoekstra, M. F., Cochran, E. J., Binder, L. I., & Kuret, J. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65219-4 · Cited by 135 · see citing works
Circadian and sleep disorder in Huntington's disease
Morton, A. J. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.10.014 · Cited by 133 · see citing works
Making the final cut: Pathogenic amyloid-β peptide generation by γ-secretase
Steiner, H., Fukumori, A., Tagami, S., & Okochi, M. (2018) · Cell Stress · doi:10.15698/cst2018.11.162 · Cited by 133 · see citing works
Plasticity and specificity of the circadian epigenome
Masri, S., & Sassone‐Corsi, P. (2010) · Nature Neuroscience · doi:10.1038/nn.2668 · Cited by 132 · see citing works
Canevelli, M., Valletta, M., Trebbastoni, A., Sarli, G., D’Antonio, F., Tariciotti, L., de Lena, C., & Bruno, G. (2016) · Frontiers in Medicine · doi:10.3389/fmed.2016.00073 · Cited by 125 · see citing works
Prion-Like Mechanisms in Parkinson’s Disease
Ma, J., Gao, J., Wang, J., & Xie, A. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00552 · Cited by 124 · see citing works
Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets
Lee, V. M.-Y., Brunden, K. R., Hutton, M., & Trojanowski, J. Q. (2011) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006437 · Cited by 122 · see citing works
Dementia severity and Lewy bodies affect circadian rhythms in Alzheimer disease
Harper, D. G., Stopa, E. G., McKee, A. C., Satlin, A., Fish, D., & Volicer, L. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2003.04.009 · Cited by 121 · see citing works
Circadian clock disruption in neurodegenerative diseases: cause and effect?
Musiek, E. S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00029 · Cited by 120 · see citing works
Kuintzle, R., Chow, E. S., Westby, T. N., Gvakharia, B. O., Giebultowicz, J. M., & Hendrix, D. A. (2017) · Nature Communications · doi:10.1038/ncomms14529 · Cited by 119 · see citing works
Baron, R., Babcock, A. A., Nemirovsky, A., Finsen, B., & Monsonego, A. (2014) · Aging Cell · doi:10.1111/acel.12210 · Cited by 118 · see citing works
Light, melatonin and the sleep-wake cycle.
Brown, G. M. (1994) · PubMed Central · Cited by 116 · see citing works
Gama, R. L., Távora, D. G. F., Bomfim, R. C., Silva, C. E., de Bruin, V. M. S., & de Bruin, P. F. C. (2010) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2010.01.002 · Cited by 116 · see citing works
Inflammation Induces TDP-43 Mislocalization and Aggregation
Correia, A. S., Patel, P., Dutta, K., & Julien, J.-P. (2015) · PLOS ONE · doi:10.1371/journal.pone.0140248 · Cited by 114 · see citing works
Treatment of Sleep Disorders in Dementia
Ooms, S. J., & Ju, Y. S. (2016) · Current Treatment Options in Neurology · doi:10.1007/s11940-016-0424-3 · Cited by 112 · see citing works
The Interplay between Alpha-Synuclein Clearance and Spreading
da Fonseca, T. L., Villar‐Piqué, A., & Outeiro, T. F. (2015) · Biomolecules · doi:10.3390/biom5020435 · Cited by 110 · see citing works
Disrupted sleep and circadian patterns in frontotemporal dementia
Anderson, K. N., Hatfield, C. F., Kipps, C., Hastings, M. H., & Hodges, J. R. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02414.x · Cited by 109 · see citing works
Circadian rhythm dysfunction: a novel environmental risk factor for Parkinson’s disease
Lauretti, E., Meco, A. D., Merali, S., & Praticò, D. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.47 · Cited by 109 · see citing works
Liu, W., Wei, S., Huang, G., Liu, L.-B., Gu, C., Shen, Y., Wang, X., Xia, S., Xie, A., Hu, L., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201901565rr · Cited by 106 · see citing works
Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese
Gu, Z., Wang, B., Zhang, Y., Ding, H., Zhang, Y., Yu, J. M., Gu, M., Chan, P., & Cai, Y. (2015) · Scientific Reports · doi:10.1038/srep15891 · Cited by 104 · see citing works
Tau physiology and pathomechanisms in frontotemporal lobar degeneration
Bodea, L., Eckert, A., Ittner, L. M., Piguet, O., & Götz, J. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13600 · Cited by 104 · see citing works
Loss of circadian clock accelerates aging in neurodegeneration-prone mutants
Krishnan, N., Rakshit, K., Chow, E. S., Wentzell, J. S., Kretzschmar, D., & Giebultowicz, J. M. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.12.034 · Cited by 99 · see citing works
Wang, H. B., Loh, D. H., Whittaker, D. S., Cutler, T., Howland, D., & Colwell, C. S. (2018) · eNeuro · doi:10.1523/eneuro.0431-17.2017 · Cited by 95 · see citing works
Yuksel, M., & Tacal, Ö. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172415 · Cited by 94 · see citing works
Rapid Eye Movement Sleep Behavior Disorder and Neurodegenerative Diseases: An Update
Zhang, F., Niu, L., Liu, X., Liu, Y., Li, S., Yu, H., & Le, W. (2020) · Aging and Disease · doi:10.14336/ad.2019.0324 · Cited by 94 · see citing works
Circadian control of pain and neuroinflammation
Segal, J. P., Tresidder, K. A., Bhatt, C., Gilron, I., & Ghasemlou, N. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24150 · Cited by 89 · see citing works
Phagocytic Roles of Glial Cells in Healthy and Diseased Brains
Jung, Y.-J., & Chung, W.-S. (2018) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.133 · Cited by 89 · see citing works
Molecular Connections Between Circadian Clocks and Aging
Welz, P.-S., & Benitah, S. A. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.12.036 · Cited by 87 · see citing works
Disruption of normal circadian clock function in a mouse model of tauopathy
Stevanovic, K. D., Yunus, A., Joly‐Amado, A., Gordon, M. N., Morgan, D., Gulick, D., & Gamsby, J. J. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.04.015 · Cited by 86 · see citing works
Self-citationDisruptive Nocturnal Behavior in Parkinson's Disease and Alzheimer's Disease
Bliwise, D. L., Watts, R. L., Watts, N., Rye, D. B., Irbe, D., & Hughes, M. L. (1995) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879500800206 · Cited by 83 · see citing works
Ma, Z., Jiang, W., & Zhang, E. E. (2016) · Scientific Reports · doi:10.1038/srep36035 · Cited by 78 · see citing works
Hippocampal clock regulates memory retrieval via Dopamine and PKA-induced GluA1 phosphorylation
Hasegawa, S., Fukushima, H., Hosoda, H., Serita, T., Ishikawa, R., Rokukawa, T., Kawahara‐Miki, R., Zhang, Y., Ohta, M., Okada, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13554-y · Cited by 77 · see citing works
Promoter methylation analysis of seven clock genes in Parkinson's disease
Lin, Q., Ding, H., Zheng, Z., Gu, Z., Ma, J., Chen, L., Chan, P., & Cai, Y. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.12.007 · Cited by 76 · see citing works
The Neurobiology of Circadian Rhythms
Sollars, P. J., & Pickard, G. E. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.003 · Cited by 75 · see citing works
Fonken, L. K., Kitt, M. M., Gaudet, A. D., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2016) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2016.07.019 · Cited by 75 · see citing works
Maemura, K., Takeda, N., & Nagai, R. (2007) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fmj06003x2 · Cited by 73 · see citing works
Bellanti, F., Iannelli, G., Blonda, M., Tamborra, R., Villani, R., Romano, A., Calcagnini, S., Mazzoccoli, G., Vinciguerra, M., Gaetani, S., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160942 · Cited by 70 · see citing works
Influence of aging on Bmal1 and Per2 expression in extra-SCN oscillators in hamster brain
Duncan, M. J., Prochot, J. R., Cook, D. H., Smith, J. T., & Franklin, K. M. (2012) · Brain Research · doi:10.1016/j.brainres.2012.11.008 · Cited by 65 · see citing works
Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy
Walsh, C. M., Yack, L. M., Walker, K., Emery, A., Varbel, J., Karageorgiou, E., Luong, P. N., Mance, I., Heuer, H. W., Boxer, A. L., et al. (2017) · SLEEP · doi:10.1093/sleep/zsx154 · Cited by 61 · see citing works
Weissová, K., Škrabalová, J., Skálová, K., Červená, K., Bendová, Z., Miletínová, E., Kopřivová, J., Šonka, K., Dudysová, D., Bartoš, A., et al. (2018) · Sleep Medicine · doi:10.1016/j.sleep.2018.07.019 · Cited by 59 · see citing works
Decreased expression of Bmal2 in patients with Parkinson's disease
Ding, H., Liu, S., Yuan, Y., Lin, Q., Chan, P., & Cai, Y. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.05.058 · Cited by 58 · see citing works
Sleep-Wake Profile in Dementia with Lewy Bodies, Alzheimer’s Disease, and Normal Aging
Cagnin, A., Fragiacomo, F., Camporese, G., Turco, M., Bussè, C., Ermani, M., & Montagnese, S. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160385 · Cited by 55 · see citing works
Means, J. C., Venkatesan, A., Gerdes, B. C., Fan, J.-Y., Bjes, E. S., & Price, J. L. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005171 · Cited by 48 · see citing works
A pilot study for circadian gene disturbance in dementia patients
Liu, H., Hu, C., Tang, Y.-C., & Chang, J. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.041 · Cited by 47 · see citing works
Chen, K., Possidente, B. P., Lomas, D. A., & Crowther, D. C. (2014) · Disease Models & Mechanisms · doi:10.1242/dmm.014134 · Cited by 44 · see citing works
Xu, F., Kula-Eversole, E., Iwanaszko, M., Hutchison, A. L., Dinner, A. R., & Allada, R. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.015 · Cited by 44 · see citing works
Parkin Mutation Affects Clock Gene-Dependent Energy Metabolism
Pacelli, C., Rotundo, G., Lecce, L., Menga, M., Bidollari, E., Scrima, R., Cela, O., Piccoli, C., Cocco, T., Vescovi, A. L., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112772 · Cited by 44 · see citing works
Yamazaki, Y., Matsubara, T., Takahashi, T., Kurashige, T., Dohi, E., Hiji, M., Nagano, Y., Yamawaki, T., & Matsumoto, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026996 · Cited by 43 · see citing works
Wang, H. B., Whittaker, D. S., Truong, D. A., Mulji, A., Ghiani, C. A., Loh, D. H., & Colwell, C. S. (2017) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.12.002 · Cited by 42 · see citing works
Inflammation: A Major Target for Compounds to Control Alzheimer’s Disease
Maccioni, R. B., Navarrete, L. P., González, A., González-Canacer, A., Guzmán‐Martínez, L., & Cortés, N. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191014 · Cited by 42 · see citing works
Wake-sleep cycles are severely disrupted by diseases affecting cytoplasmic homeostasis
Beesley, S., Kim, D. W., D'Alessandro, M. R., Jin, Y., Lee, K., Joo, H., Young, Y., Tomko, R. J., Faulkner, J., Gamsby, J. J., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003524117 · Cited by 42 · see citing works
Self-citationSleep, Performance, and Memory in Flies
Dissel, S., Melnattur, K. V., & Shaw, P. J. (2015) · Current Sleep Medicine Reports · doi:10.1007/s40675-014-0006-4 · Cited by 41 · see citing works
Buhl, E., Higham, J. P., & Hodge, J. J. L. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104507 · Cited by 41 · see citing works
Relationships between the Circadian System and Alzheimer's Disease-Like Symptoms in Drosophila
Long, D. M., Blake, M. R., Dutta, S., Holbrook, S. D., Kotwica‐Rolinska, J., Kretzschmar, D., & Giebultowicz, J. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0106068 · Cited by 39 · see citing works
Atherosclerosis and Neurodegeneration
Iadecola, C. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000102660.99744.85 · Cited by 39 · see citing works
Sani, T. P., Bond, R. L., Marshall, C. R., Hardy, C. J. D., Russell, L. L., Moore, K. M., Slattery, C. F., Paterson, R. W., Woollacott, I., Wendi, I. P., et al. (2019) · eNeurologicalSci · doi:10.1016/j.ensci.2019.100212 · Cited by 39 · see citing works
Kundermann, B., Thum, A., Rocamora, R., Haag, A., Krieg, J.-C., & Hemmeter, U. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.07.008 · Cited by 38 · see citing works
Li, H., Song, S., Wang, Y., Huang, C., Zhang, F., Liu, J., & Hong, J. (2018) · Neurotoxicity Research · doi:10.1007/s12640-018-9968-1 · Cited by 36 · see citing works
Dedeene, L., Schoor, E. V., Vandenberghe, R. R., Damme, P. V., Poesen, K., & Thal, D. R. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0845-9 · Cited by 36 · see citing works
Wang, X., Wang, L., Yu, Q., Xu, Y., Zhang, L., Zhao, X., Cao, X., Li, Y., & Li, L. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.026 · Cited by 31 · see citing works
Roby, D. A., Ruiz, F., Kermath, B. A., Voorhees, J. R., Niehoff, M. L., Zhang, J., Morley, J. E., Musiek, E. S., Farr, S. A., & Burris, T. P. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215004 · Cited by 31 · see citing works
Mutant huntingtin disturbs circadian clock gene expression and sleep patterns in Drosophila
Faragó, A., Zsindely, N., & Bodai, L. (2019) · Scientific Reports · doi:10.1038/s41598-019-43612-w · Cited by 31 · see citing works
Sundaram, S. S., Nagaraj, S., Mahoney, H. L., Portugues, A., Li, W., Millsaps, K., Faulkner, J., Yunus, A., Burns, C. I., Bloom, C., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-50197-x · Cited by 30 · see citing works
Self-citationManipulations of amyloid precursor protein cleavage disrupt the circadian clock in aging Drosophila
Blake, M. R., Holbrook, S. D., Kotwica‐Rolinska, J., Chow, E. S., Kretzschmar, D., & Giebultowicz, J. M. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.012 · Cited by 29 · see citing works
Circadian dysfunction in the Q175 model of Huntington's disease: Network analysis
Smarr, B. L., Cutler, T., Loh, D. H., Kudo, T., Kuljis, D. A., Kriegsfeld, L. J., Ghiani, C. A., & Colwell, C. S. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24505 · Cited by 29 · see citing works
Rest-activity rhythm disruption in progressive supranuclear palsy
Walsh, C. M., Yack, L. M., Varbel, J., Walker, K., Grinberg, L. T., Boxer, A. L., Kramer, J. H., Miller, B. L., & Neylan, T. C. (2016) · Sleep Medicine · doi:10.1016/j.sleep.2016.05.002 · Cited by 26 · see citing works
Up-regulation of casein kinase 1ε is involved in tau pathogenesis in Alzheimer’s disease
Chen, C., Gu, J., Basurto‐Islas, G., Jin, N., Wu, F., Gong, C., Iqbal, K., & Liu, F. (2017) · Scientific Reports · doi:10.1038/s41598-017-13791-5 · Cited by 23 · see citing works
Kuljis, D. A., Schroeder, A., Kudo, T., Loh, D. H., Willison, D. L., & Colwell, C. S. (2012) · PubMed · Cited by 21 · see citing works
The clock gene period differentially regulates sleep and memory in Drosophila
Fropf, R., Zhou, H., & Yin, J. C. P. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.02.016 · Cited by 19 · see citing works
Ouk, K., Aungier, J., & Morton, A. J. (2016) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.11.004 · Cited by 18 · see citing works
Elevation of casein kinase 1ε associated with TDP‐43 and tau pathologies in Alzheimer's disease
Gu, J., Hu, W. H., Tan, X., Qu, S., Chu, D., Gong, C., Iqbal, K., & Liu, F. (2019) · Brain Pathology · doi:10.1111/bpa.12775 · Cited by 18 · see citing works
Zhang, S., & Sehgal, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812536-6.00011-0 · Cited by 12 · see citing works
Adaptation to Experimental Jet-Lag in R6/2 Mice despite Circadian Dysrhythmia
Wood, N. I., McAllister, C., Cuesta, M., Aungier, J., Fraenkel, E., & Morton, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055036 · Cited by 12 · see citing works
Venkatesan, A., Fan, J.-Y., Bouyain, S., & Price, J. L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040813 · Cited by 10 · see citing works
Effects of Amylin Against Amyloid-β-Induced Tauopathy and Synapse Loss in Primary Neurons
Gan, Q., Yao, H., Na, H., Ballance, H. I., Tao, Q., Leung, L., Tian, H., Zhu, H., Wolozin, B. L., & Qiu, W. Q. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190161 · Cited by 9 · see citing works
Nonaka, T., Masai, H., & Hasegawa, M. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2014.05.1533 · Cited by 4 · see citing works
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- Trenkwalder C. Arnulf I. Postuma R. (2017). Principles and Practice of Sleep Medicine. Amsterdam: Elsevier Inc.,.
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Role of neuroinflammation in neurodegeneration development
Zhang, W., Xiao, D., Mao, Q., & Xia, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01486-5 · Cited by 1,668 · see citing works
“It has been reported that circadian locomotor output cycles protein kaput (CLOCK), cryptochrome (CRY) and brain and muscle ARNT-like protein 1 (BMAL1) can regulate the secretion of cytokines and chemokines through many immune mediator genes.(121) In vivo BMAL1 deletion was found to induce activation of glial cells and…”
BackgroundMitochondria: It is all about energy
Casanova, A., Wevers, A., Ledesma, S. N., & Pruimboom, L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1114231 · Cited by 335 · see citing works
Whittaker, D. S., Akhmetova, L., Carlin, D., Romero, H., Welsh, D. K., Colwell, C. S., & Desplats, P. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.07.014 · Cited by 147 · see citing works
Başer, K. H. C., Haskologlu, I. C., & Erdağ, E. (2025) · Molecules · doi:10.3390/molecules30091888 · Cited by 60 · see citing works
Yalçın, M., Mundorf, A., Thiel, F., Amatriain‐Fernández, S., Kalthoff, I. S., Beucke, J., Budde, H., Garthus‐Niegel, S., Peterburs, J., & Relógio, A. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.873237 · Cited by 46 · see citing works
Pathogenesis of Neurodegenerative Diseases and the Protective Role of Natural Bioactive Components
Samanta, S., Chakraborty, S., & Bagchi, D. (2023) · Journal of the American Nutrition Association · doi:10.1080/27697061.2023.2203235 · Cited by 43 · see citing works
Challenges and Opportunities of Targeting Astrocytes to Halt Neurodegenerative Disorders
Valori, C. F., Possenti, A., Brambilla, L., & Rossi, D. (2021) · Cells · doi:10.3390/cells10082019 · Cited by 37 · see citing works
A Dichotomous Role for FABP7 in Sleep and Alzheimer’s Disease Pathogenesis: A Hypothesis
Needham, H., Torpey, G., Flores, C. C., Davis, C. J., Vanderheyden, W. M., & Gerstner, J. R. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.798994 · Cited by 28 · see citing works
Trujillo-Rangel, W. Á., Acuña-Vaca, S., Padilla-Ponce, D. J., García-Mercado, F. G., Torres-Mendoza, B. M., Pacheco-Moisés, F. P., Escoto-Delgadillo, M., García‐Benavides, L., & Delgado-Lara, D. L. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084401 · Cited by 27 · see citing works
Ribeiro, R. F. N., Pereira, D., de Almeida, L. P., Silva, M. M., & Cavadas, C. (2022) · Aging Clinical and Experimental Research · doi:10.1007/s40520-022-02257-y · Cited by 26 · see citing works
Circadian regulation in aging: Implications for spaceflight and life on earth
Malhan, D., Schoenrock, B., Yalçın, M., Blottner, D., & Relógio, A. (2023) · Aging Cell · doi:10.1111/acel.13935 · Cited by 25 · see citing works
Kaczmarczyk, L., Schleif, M., Dittrich, L., Williams, R. H., Koderman, M., Bansal, V., Rajput, A., Schulte, T., Jonson, M., Krost, C., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010747 · Cited by 21 · see citing works
CK2 and protein kinases of the CK1 superfamily as targets for neurodegenerative disorders
Baier, A., & Szyszka, R. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.916063 · Cited by 22 · see citing works
Schoettner, K., Alonso, M., Button, M., Goldfarb, C., Herrera, J., Quteishat, N., Meyer, C., Bergdahl, A., & Amir, S. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.922080 · Cited by 21 · see citing works
Impact of circadian clock dysfunction on human health
Samanta, S., & Ali, S. A. (2022) · Exploration of neuroscience · doi:10.37349/en.2022.00002 · Cited by 20 · see citing works
Bains, R. S., Forrest, H., Sillito, R. R., Armstrong, J. D., Stewart, M. E., Nolan, P. M., & Wells, S. E. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1148172 · Cited by 16 · see citing works
Dementia Friendly Buildings—Approach on Architectures
Ghamari, M., Suvish, Dehkordi, A. A., See, C. H., Sami, A., Yu, H., & Sundaram, S. (2025) · Buildings · doi:10.3390/buildings15030385 · Cited by 14 · see citing works
Meur, M. L., Pignatelli, J., Blasi, P., & Palomo, V. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115561 · Cited by 14 · see citing works
Circadian system and aging: where both times interact
Cobarro, C., Soares, L. I., Kutsenko, Y., & Tomás‐Loba, A. (2025) · Frontiers in Aging · doi:10.3389/fragi.2025.1646794 · Cited by 15 · see citing works
Alternative Splicing Mechanisms Underlying Opioid-Induced Hyperalgesia
Zhang, P., Perez, O. C., Southey, B. R., Sweedler, J. V., Pradhan, A. A. A., & Rodriguez‐Zas, S. L. (2021) · Genes · doi:10.3390/genes12101570 · Cited by 11 · see citing works
Sadhukhan, D., Biswas, A., Mishra, S., Chatterjee, K., Maji, D., Mitra, P., Mukherjee, P., Podder, G., Ray, B. K., Biswas, A., et al. (2023) · NeuroMolecular Medicine · doi:10.1007/s12017-023-08761-2 · Cited by 10 · see citing works
Differential expression of the circadian clock network correlates with tumour progression in gliomas
Petković, M., Yalçın, M., Heese, O., & Relógio, A. (2023) · BMC Medical Genomics · doi:10.1186/s12920-023-01585-w · Cited by 8 · see citing works
Light in ecological settings: Entrainment, circadian disruption, and interventions
Fischer, D. R., & Hilditch, C. J. (2022) · Progress in brain research · doi:10.1016/bs.pbr.2022.04.001 · Cited by 5 · see citing works
Ludwig, M., Basti, A., Yalçın, M., Schulte, J. H., & Relógio, A. (2023) · BMC Pediatrics · doi:10.1186/s12887-023-03921-6 · Cited by 4 · see citing works
Flores, C. C., Lee, Y., Davis, C. J., Solverson, P. M., & Gerstner, J. R. (2025) · Biomolecules · doi:10.3390/biom15101432 · Cited by 3 · see citing works
Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications
Singh, B., Pigazzani, F., & Manfredini, R. (2026) · Neuroprotection/Neuroprotection (Chichester, England. Print) · doi:10.1002/nep3.70046 · Cited by 3 · see citing works
Yalçın, M., & Relógio, A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0293226 · Cited by 3 · see citing works
Yalçın, M., Peralta, A. R., Bentes, C. C., Silva, C., Guerreiro, T., Ferreira, J. J., & Relógio, A. (2024) · PLoS ONE · doi:10.1371/journal.pone.0305712 · Cited by 3 · see citing works
Spatial transcriptomics reveals brain-wide circadian disruption in an Alzheimer’s disease modelPreprint
Gelber, A., Romero, H. K., Burrows, D. R. W., Whittaker, D. S., Carlin, D. E., Mukamel, E. A., & Desplats, P. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.26.701799 · Cited by 3 · see citing works
Park, Y., Kang, H., Kang, S. J., Ku, H., Zarbl, H., Fang, M., & Park, J. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03686-6 · Cited by 2 · see citing works
Prakash, P., Pradhan, A. K., & Sheeba, V. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.049447 · Cited by 2 · see citing works
Measuring circadian rhythms in patients with dementia: protocol for a scoping reviewPreprint
Gabb, V. G., Ince, L. M., Rudd, S., & Coulthard, E. J. (2022) · medRxiv · doi:10.1101/2022.06.06.22275886
Circadian dysregulation and Alzheimer’s disease: A comprehensive review
Iacobelli, P. (2022) · Brain Science Advances · doi:10.26599/bsa.2022.9050021
Cebuc, M., Rotaru, L., Lupusor, A., Moldovanu, I., Grosu, O., Cărăușu, G., & Vovc, V. (2022) · Bulletin of the Academy of Sciences of Moldova Medical Sciences · doi:10.52692/1857-0011.2022.3-74.01
Petković, M., Yalçın, M., Heese, O., & Relógio, A. (2023) · Figshare · doi:10.6084/m9.figshare.23621265
Neurodegenerative diseases and circadian rhythm dysfunction: A bidirectional nexus
Samanta, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-95735-9.00033-4
Use of Basket Trials to Solve Sleep Problems in Patients with Rare Diseases
Pullen, L. C., Bott, N., McCanless, C., Revana, A., Sevinc, G., Gorman, C., Duncan, A., Poliquin, S., Pfalzer, A. C., Schmidt, K. Q., et al. (2024) · Clocks & Sleep · doi:10.3390/clockssleep6040044
Kumar, V., Bharti, N., Mukherjee, S., Das, S., Das, D., Kashyap, D., & Kumar, M. (2025) · Biological Rhythm Research · doi:10.1080/09291016.2025.2598545
Petković, M., Yalçın, M., Heese, O., & Relógio, A. (2023) · Figshare · doi:10.6084/m9.figshare.23621268
Godlewska, D., Kleszczewska, K., Pruska, A., Senatorska, N., Rarok, J., Pietruszewska, H., Banaszek, M., Panfil, A., Błocka, J., & Lurka, A. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.4(48).2025.4231
A DIA-based quantitative crosslinking mass spectrometry framework for dynamic structural proteomicsPreprint
Birklbauer, M. J., Geetha, S. S., Getreuer, P., Grabmann, G., Hollenstein, D. M., Kandioller, W., Dorfer, V., Jantsch, V., Mechtler, K., & Müller, F. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.16.732730
Abdelaziz, A. M., & Eladawy, R. M. (2026) · Metabolic Brain Disease · doi:10.1007/s11011-026-02004-6
- Authors
- Carter, B., Justin, H. S., Gulick, D., & Gamsby, J. J.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Gamsby, Joshua J.
- Venue
- Frontiers in Molecular Biosciences
- Publisher
- Frontiers Media SA
- Published
- 2021-03-26
- Volume
- 8
- Pages
- 644747-644747
- ISSN
- 2296-889X (ISSN-L)
- PMC
- PMC8056266
- OpenAlex
- W3151775086
- Cited by
- 42
- References
- 164
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 5 · 2023: 11 · 2022: 12 · 2021: 2
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Molecular Biosciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Florida Department of Health (9AZ31, 7AZ13)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- circadian clock, neurodegenerative diseases, body temperature rhythm, neuroinflammation, stress, shift work
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